Cellular functions and biomedical applications of circular RNAs DOI Creative Commons
Zheyu Zhang,

Zefeng Wang

Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Circular RNAs (circRNAs) have emerged as a large class of stable and conserved that are derived primarily from back-splicing pre-mRNAs expressed in cell- tissue-specific fashion. Recent studies indicated subset circRNAs may undergo translation through cap-independent pathways mediated by internal ribosome entry sites (IRESs), m6A modifications, or IRES-like short elements. Considering the stability low immunogenicity circRNAs,

Language: Английский

Emerging Delivery Systems for Enabling Precision Nucleic Acid Therapeutics DOI

Xiaochun Bian,

Liping Zhou,

Zhiwei Luo

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.

Language: Английский

Citations

2
Recent Advances in the Development and Efficacy of Anti-Cancer Vaccines—A Narrative Review DOI Creative Commons
Kajetan Kiełbowski,

Paulina Plewa,

Jan Zadworny

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(3), P. 237 - 237

Published: Feb. 25, 2025

Immunotherapy is an established and efficient treatment strategy for a variety of malignancies. It aims to boost the anticancer properties one’s own immune system. Several immunotherapeutic options are available, but checkpoint blockers represent most widely known investigated. Anticancer vaccines evolving area immunotherapy that stimulate antigen-presenting cells, cytotoxic responses CD8+ T presence memory among others. Over years, different approaches have been studied, such as mRNA DNA vaccines, together with dendritic cell- viral vector-based vaccines. Recently, accumulating number clinical studies performed analyze safety potential efficacy these agents. The aim this review summarize recent advances regarding types therapeutic Furthermore, it will discuss how in preclinical models can enhance outcomes.

Language: Английский

Citations

0
Cell-free DNA: plays an essential role in early diagnosis and immunotherapy of pancreatic cancer DOI Creative Commons
Yi Wen, Grace Zhao, Chunhua Dai

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 7, 2025

Pancreatic cancer is renowned for its aggressive nature and dismal prognosis, with the majority of patients diagnosed at an advanced stage. The prognosis pancreatic can be improved by early diagnosis effective treatment. Circulating cell-free DNA (cfDNA) has emerged as a promising biomarker monitoring cancer. This research presents review circulating essential role in immunotherapy detection methods cfDNA, potential diagnostic biomarker, latest progress cfDNA-based are discussed. findings suggest that cfDNA plays vital personalised treatment cancer, holding great promise improving patient outcomes.

Language: Английский

Citations

0
Polycations Improve Intracellular Stability of mRNA Delivered Using Lipid Nanoparticles for Prolonged Protein Expression DOI Creative Commons

Jumpei Norimatsu,

Rashida Hashim,

Theofilus A. Tockary

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Lipid Nanoparticles for mRNA Delivery in Cancer Immunotherapy DOI
Yasir Alshehry, Xiang Liu,

Wenhua Li

et al.

The AAPS Journal, Journal Year: 2025, Volume and Issue: 27(3)

Published: March 18, 2025

Language: Английский

Citations

0
Cellular functions and biomedical applications of circular RNAs DOI Creative Commons
Zheyu Zhang,

Zefeng Wang

Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Circular RNAs (circRNAs) have emerged as a large class of stable and conserved that are derived primarily from back-splicing pre-mRNAs expressed in cell- tissue-specific fashion. Recent studies indicated subset circRNAs may undergo translation through cap-independent pathways mediated by internal ribosome entry sites (IRESs), m6A modifications, or IRES-like short elements. Considering the stability low immunogenicity circRNAs,

Language: Английский

Citations

1