Microbial siderophores for One Health DOI Creative Commons
Zhong Wei, Shaohua Gu, Vera Vollenweider

et al.

Trends in Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

One Health is an integrative concept striving for healthy environments, animals, and humans. Microbes play a fundamental role this as they are key drivers of ecosystem stability host health. A central microbial feature across various environments the secretion siderophores, low-molecular-weight metabolites that chelate ferric iron (Fe3+) with high affinity. We propose that, by steering metal availability, siderophores can be important in four areas via: (i) enhancing crop yield, (ii) mitigating heavy pollution, (iii) preventing pathogen colonization, (iv) serving potential treatments established infections. Collectively, attractive molecules to complement our efforts increasing human, animal, environmental

Language: Английский

Genomic Insights into Cobweb Disease Resistance in Agaricus bisporus: A Comparative Analysis of Resistant and Susceptible Strains DOI Creative Commons

Guohui Cheng,

Xiaoya An, Yueting Dai

et al.

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(3), P. 200 - 200

Published: March 4, 2025

Agaricus bisporus, a globally cultivated edible fungus, faces significant challenges from fungal diseases like cobweb disease caused by Cladobotryum mycophilum, which severely impacts yield. This study aimed to explore the genetic basis of resistance in A. bisporus comparing genomes susceptible strain (AB7) and resistant (AB58). Whole-genome sequencing AB7 was performed using PacBio Sequel SMRT technology, comparative genomic analyses were conducted alongside AB58 other hosts C. mycophilum. Comparative revealed distinct features AB58, including enriched regulatory elements, specific deletions affecting carbohydrate-active enzymes (CAZymes), unique cytochrome P450 (CYP) profiles. Notably, harbored more genes related fatty acid metabolism NI-siderophore synthetase genes, contributing its enhanced environmental adaptability resistance. Pan-genome analysis highlighted diversity, with strain-specific pathways aflatoxin biosynthesis ether lipid metabolism, suggesting evolutionary adaptations. These findings provide valuable insights into underlying offering foundation for future breeding strategies improve crop resilience.

Language: Английский

Citations

0
Microbial siderophores for One Health DOI Creative Commons
Zhong Wei, Shaohua Gu, Vera Vollenweider

et al.

Trends in Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

One Health is an integrative concept striving for healthy environments, animals, and humans. Microbes play a fundamental role this as they are key drivers of ecosystem stability host health. A central microbial feature across various environments the secretion siderophores, low-molecular-weight metabolites that chelate ferric iron (Fe3+) with high affinity. We propose that, by steering metal availability, siderophores can be important in four areas via: (i) enhancing crop yield, (ii) mitigating heavy pollution, (iii) preventing pathogen colonization, (iv) serving potential treatments established infections. Collectively, attractive molecules to complement our efforts increasing human, animal, environmental

Language: Английский

Citations

0