Nanomaterials‐Based Drug Delivery Systems for Therapeutic Applications in Osteoporosis

Advanced Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract The etiology of osteoporosis is rooted in the disruption intricate equilibrium between bone formation and resorption processes. Nevertheless, conventional anti‐osteoporotic medications hormonal therapeutic regimens currently employed clinical practice are associated with a multitude adverse effects, thereby constraining their overall efficacy potential. Recently, nanomaterials have emerged as promising alternative due to minimal side efficient drug delivery, ability enhance formation, aiding restoring balance. This review delves into fundamental principles remodeling microenvironment, well current treatment approaches for osteoporosis. It subsequently explores research status nanomaterial‐based delivery systems treatment, encompassing inorganic nanomaterials, organic cell‐mimicking carriers exosomes mimics emerging therapies targeting microenvironment. Finally, discusses potential nanomedicine treating outlines future trajectory this burgeoning field. aim provide comprehensive reference application strategies therapy, fostering further advancements innovations critical area medical

Language: Английский

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Nitric Oxide‐Mediated Dual‐Functional Smart Titanium Implant Coating for Antibacterial and Osseointegration Promotion in Implant‐Associated Infections

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract The balance of antibacterial and osseointegration‐promoting properties on titanium (Ti) implants in a simple efficient manner is crucial for the management implant‐associated infections, condition that has become significant global health concern. Herein, nitric oxide (NO)‐mediated dual‐function smart coating with developed Ti implants. leverages distinct NO at high low concentrations to enable an on‐demand functional switch. Specifically, function achieved through rapid release high‐dose response infection microenvironment near‐infrared stimulation. Once resolved normal physiological conditions are restored, gradually releases low‐dose promote osseointegration. In vitro tests confirm exhibits ratio 97.84% 97.18% against methicillin‐resistant Staphylococcus aureus its biofilms, respectively, demonstrates ability activate osteoblasts. rat femoral model further certifies responsive mechanism efficiently facilitates switch between properties. Notably, use dual‐functional nonantibiotic agent, NO, significantly mitigates risk bacterial resistance.

Language: Английский

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Nitric oxide-delivering surface modification for tailoring cell-material interactions on medical device surface: From surface-functionalized design to therapeutic applications

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162378 - 162378

Published: April 1, 2025

Language: Английский

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Current Status and Perspectives of Research on Polymer Hydrogels in the Treatment and Protection of Osteoarthritis

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Arthritis is a degenerative disease characterized by chronic cartilage degeneration. It affects hundreds of millions people worldwide and often has serious consequences such as joint pain swelling, limited mobility, deformity. However, conventional treatments still struggle to achieve satisfactory results. Finding more effective for arthritis remains an important clinical challenge. As hydrogels have unique 3D spatial mesh structure, significant material interaction ability, adjustable mechanical properties, good biodegradability, they can provide suitable cellular or tissue microenvironment, their potential in scaffolding effect, lubrication, anti‐inflammatory drug delivery expected be potent therapeutic approach the treatment osteoarthritis. In this review, three aspects hydrogel products osteoarthritis are comprehensively summarized discussed, namely, selection gel design, exploration cross‐linking mechanisms, mechanisms therapy osteoarthritis, focus on advantages limitations applications, which point out direction development strategy innovative field, applied research, transformation.

Language: Английский

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Innovative modification strategies and emerging applications of natural hydrogel scaffolds for osteoporotic bone defect regeneration

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 28, 2025

Osteoporosis, a prevalent systemic metabolic bone disease, is characterized by diminished mass, microarchitectural deterioration of tissue, and heightened fragility. In osteoporotic patients, chronic progressive loss often leads to fractures and, in advanced cases, critical-sized defects. While traditional repair approaches are constrained significant limitations, the advent bioactive scaffolds has transformed therapeutic paradigm for regeneration. Among these innovations, natural polymer-based hydrogel have emerged as particularly promising solution tissue engineering, owing their superior biocompatibility, tunable biodegradation properties, exceptional ability replicate native extracellular matrix environment. This review systematically explores recent breakthroughs modification techniques applications defect repair, while critically analyzing existing clinical challenges proposing future research trajectories this rapidly evolving field.

Language: Английский

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Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract The repair of osteoporotic bone defects remains inadequately addressed, primarily due to a disruption in homeostasis, characterized by insufficient formation and excessive resorption. Current research either focuses on promoting or inhibiting resorption, however, the efficacy these single‐target therapeutic strategies is limited. Herein, “two‐way regulation” homeostasis strategy proposed utilizing piezoelectric composite membranes (DAT/KS), capable simultaneously regulating osteogenesis osteoclastogenesis, with high performance, good biocompatibility, excellent degradability, promote regeneration under conditions. DAT/KS membrane ultrasound (US) treatment enables controlled modulation stimulation release saikosaponin D (SSD), which promotes osteogenic differentiation while osteoclast function, thereby effectively restoring enhancing repair. Mechanistic insights reveal promotion both canonical non‐canonical Wnt signaling marrow mesenchymal stem cells (BMSCs), determines their fate, downregulation NF‐κB mononuclear macrophages (BMMs). This study presents optimized sono‐piezoelectric biomaterials bidirectionally osteoclastic differentiation, providing new potential approach for pathological injuries.

Language: Английский

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Progress in Research on Metal Ion Crosslinking Alginate-Based Gels

Gels, Journal Year: 2024, Volume and Issue: 11(1), P. 16 - 16

Published: Dec. 27, 2024

Alginate is an important natural biopolymer and metal ion-induced gelation one of its most significant functional properties. Alginate-based hydrogels crosslinked with ions are commonly utilized in the food, biomedical, tissue engineering, environment fields. The process alginate has been subject thorough research over last few decades. This review aims to summarize mechanisms induced by different cations (primarily including Ca2+, Ba2+, Cu2+, Sr2+, Fe2+/Fe3+, Al3+). Metal shows preferences for α-L-guluronic acid (G), β-D-mannuronic (M), GM blocks. Some can also selectively bind carboxyl groups guluronic acid. properties applications these alginate-based discussed. primary objective this provide useful information exploring practical alginate.

Language: Английский

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