Nucleic Acid‐Locked Smart Carrier for Photothermal/Chemotherapy‐Amplified Immunogenic Cell Death to Enhance Systemic Antitumor Efficacy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Immunotherapy holds great promise in the fight against cancer; however, it often encounters poor immunogenicity with limited therapeutic efficacy. Combining multiple treatment modalities provides a trustworthy strategy for achieving robust antitumor effect. In this study, nucleic acid‐locked smart carrier (NASC) is developed to amplify immunogenic cell death (ICD) through synergistic integration of photothermal therapy (PTT) and chemotherapy high‐performance monotherapy. Mesoporous silica‐coated gold nanorod (MSGNR) serves as reservoir anticancer drug doxorubicin (DOX) capped sequence‐specific duplex unit containing tumor‐specific targeting AS1411 fragment, resulting formation NASC. With targeting, NASC can specifically target be internalized into tumor cells high expression nucleolin, where capping unlocked by intracellularly overexpressed adenosine triphosphate. Subsequently, released DOX synergized MSGNR‐mediated PTT following laser irradiation induces direct killing, which, concurrently, triggers ICD activate antineoplastic immunity an increased number T lymphocytes. This triple‐collaborative strategy, further combined anti‐programmed death‐1 antibody (αPD‐1)‐mediated immune checkpoint blockade (ICB) therapy, shows efficacy both unilateral bilateral models.

Language: Английский

Combating cancer immunotherapy resistance: a nano‐medicine perspective

Cancer Communications, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading resistance. Various functionalized nanoparticles (NPs), modified with cationic lipids, pH‐sensitive compounds, or photosensitizers, exhibit unique physicochemical properties facilitate targeted delivery therapeutic agents tumor microenvironment (TME). These NPs are engineered modify activity. The crucial signal transduction pathways by which counteract resistance outlined, including enhancing antigen presentation, boosting activation infiltration tumor‐specific cells, inducing immunogenic cell death, counteracting immunosuppressive conditions in TME. Additionally, review summarizes current clinical trials involving NP‐based immunotherapy. Ultimately, it highlights potential nanotechnology advance

Language: Английский

Hyaluronic acid-modified doxorubicin-covalent organic framework nanoparticles triggered pyroptosis in combinations with immune checkpoint blockade for the treatment of breast cancer

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143265 - 143265

Published: April 1, 2025

Language: Английский