Aging promotes reactivation of the Barr body at distal chromosome regions

Nature Aging, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

---

Why women’s brains are more resilient: it could be their ‘silent’ X chromosome

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

---

Why women experience Alzheimer’s disease differently from men

Nature, Journal Year: 2025, Volume and Issue: 640(8059), P. S14 - S17

Published: April 16, 2025

Language: Английский

---

Cell-Type-Specific Transposable Element Demethylation and TAD Remodeling in the Aging Mouse Brain

Published: Jan. 1, 2025

Language: Английский

---

Single Cell Landscape of Sex-specific Drivers of Alzheimer’s Disease

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Background Sex differences in Alzheimer’s disease (AD) have been documented for decades, and many sex-specific molecular contributors to AD discovered through bulk omics analysis of brain tissues. RNA sequencing (RNAseq) at single cell resolution provides an opportunity characterize transcript associations with a type-specific matter. Here, we investigated gene expression neuropathology cognitive manifestation (endophenotypes) leveraging large single-nucleus transcriptomic dataset consisting 1.64 million nuclei from dorsolateral prefrontal cortex (DLPFC) tissue 424 unique donors the Religious Orders Study Memory Aging Project (ROS/MAP; Knowledge Portal syn2580853). Methods ROS/MAP RNAseq data (snRNA-seq) were processed rigorous pipeline. In total, eight major types DLPFC identified. We first performed sex-stratified sex-interaction association analyses by fitting negative binomial mixed models relation β-amyloid load (Aβ), paired helical filament tau tangle density (tau), global performance last visit, longitudinal trajectory. then conducted gene-set enrichment identify functional signaling pathways enriched associations. Lastly, compared differential patterns intercellular communication profiles between sexes diagnostic groups among types. For replication, examined using snRNA-seq derived tissue-derived independent set 84 The Seattle Disease Brain Cell Atlas (SEA-AD) study. Results 68% participants female, 52% diagnosed dementia. identified several disease-dependent or sex-dependent subpopulations. Then 2,660 involving 2,110 genes Aβ (51%), (21%), (29%). 60% female-specific Aβ, 49% male-specific tau. vast majority (93%) female protective neurons, most (76%) risk glial cells. Nine replicated SEA-AD cohort, including ADGRV1 OR3A3 Aβ; IFI27L1 , LYRM1 STAP2 TSTD2 tau; PDYN cognition; TMEM50B decline. All except observed neurons. Furthermore, preponderance neurons was also recapitulated cohort. Sex-specific immune, inflammation, damage-related stress response pathways, microglia presented pathways. Finally, six ITGB1-mediated microglia-specific incoming signals that may play role accumulation. Conclusion Our study highlights transcriptome-wide, single-cell landscape delineate full scope associations, expression, pathway, cell-cell network changes each type, while identifying replicating help direct future mechanistic studies.

Language: Английский

---

Le chromosome X : un bouclier contre le déclin cognitif ?

Cerveau & Psycho, Journal Year: 2025, Volume and Issue: n° 176(5), P. 8 - 8

Published: April 8, 2025

---

Der große Unterschied

Nachrichten aus der Chemie, Journal Year: 2025, Volume and Issue: 73(5), P. 77 - 79

Published: April 30, 2025

Abstract Geschlechter‐Unterschiede sind in der Medizin relevant, etwa im Immunsystem, bei Herzinfarkten und Wirkung von Medikamenten. Und sie zu lange vernachlässigt worden. Es bleibt noch einiges verbessern, bis jede:r die richtige Behandlung bekommt.

---

X inactivation shows frail ends when mice age

Nature Aging, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

---