Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Cell Death and Differentiation, Journal Year: 2018, Volume and Issue: 25(3), P. 486 - 541

Published: Jan. 23, 2018

Over the past decade, Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for definition and interpretation of cell death from morphological, biochemical, functional perspectives. Since field continues to expand novel mechanisms that orchestrate multiple pathways are unveiled, we propose an updated classification subroutines focusing mechanistic essential (as opposed correlative dispensable) aspects process. As provide molecularly oriented definitions terms including intrinsic apoptosis, extrinsic mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic death, NETotic lysosome-dependent autophagy-dependent immunogenic cellular senescence, mitotic catastrophe, discuss utility neologisms refer highly specialized instances these processes. The mission NCCD is a widely accepted nomenclature in support continued development field.

Language: Английский

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Ferroptosis: mechanisms, biology and role in disease

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(4), P. 266 - 282

Published: Jan. 25, 2021

Language: Английский

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Mechanisms of ferroptosis

Cellular and Molecular Life Sciences, Journal Year: 2016, Volume and Issue: 73(11-12), P. 2195 - 2209

Published: April 5, 2016

Ferroptosis is a non-apoptotic form of cell death that can be triggered by small molecules or conditions inhibit glutathione biosynthesis the glutathione-dependent antioxidant enzyme peroxidase 4 (GPX4). This lethal process defined iron-dependent accumulation lipid reactive oxygen species and depletion plasma membrane polyunsaturated fatty acids. Cancer cells with high level RAS-RAF-MEK pathway activity p53 expression may sensitized to this process. Conversely, number molecule inhibitors ferroptosis have been identified, including ferrostatin-1 liproxstatin-1, which block pathological events in brain, kidney other tissues. Recent work has identified genes required for ferroptosis, those involved amino acid metabolism. Outstanding questions include relationship between forms death, whether activation inhibition exploited achieve desirable therapeutic ends.

Language: Английский

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Acetyl Coenzyme A: A Central Metabolite and Second Messenger

Cell Metabolism, Journal Year: 2015, Volume and Issue: 21(6), P. 805 - 821

Published: June 1, 2015

Language: Английский

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Autophagy in malignant transformation and cancer progression

The EMBO Journal, Journal Year: 2015, Volume and Issue: 34(7), P. 856 - 880

Published: Feb. 23, 2015

Language: Английский

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Mitochondrial metabolism and cancer

Cell Research, Journal Year: 2017, Volume and Issue: 28(3), P. 265 - 280

Published: Dec. 8, 2017

Glycolysis has long been considered as the major metabolic process for energy production and anabolic growth in cancer cells. Although such a view instrumental development of powerful imaging tools that are still used clinics, it is now clear mitochondria play key role oncogenesis. Besides exerting central bioenergetic functions, provide indeed building blocks tumor anabolism, control redox calcium homeostasis, participate transcriptional regulation, govern cell death. Thus, constitute promising targets novel anticancer agents. However, tumors arise, progress, respond to therapy context an intimate crosstalk with host immune system, many immunological functions rely on intact mitochondrial metabolism. Here, we review cell-intrinsic cell-extrinsic mechanisms through which influence all steps oncogenesis, focus therapeutic potential targeting metabolism therapy.

Language: Английский

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AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

Science, Journal Year: 2016, Volume and Issue: 351(6270), P. 275 - 281

Published: Jan. 15, 2016

Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons and mitochondrial DNA-linked disease mutations, yet how these stimuli mechanistically connect the fission fusion machinery is poorly understood. We found that energy-sensing adenosine monophosphate (AMP)-activated protein kinase (AMPK) genetically required for cells rapid after treatment with ETC inhibitors. Moreover, direct pharmacological activation of AMPK was sufficient rapidly promote even absence stress. A screen substrates identified factor (MFF), a outer-membrane receptor DRP1, cytoplasmic guanosine triphosphatase catalyzes fission. Nonphosphorylatable phosphomimetic alleles sites MFF revealed it key effector AMPK-mediated

Language: Английский

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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Journal for ImmunoTherapy of Cancer, Journal Year: 2020, Volume and Issue: 8(1), P. e000337 - e000337

Published: March 1, 2020

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular microenvironmental features determine the propensity of RCD drive immunity. Here, we provide updated operational definition immunogenic (ICD), discuss key factors that dictate ability dying cells response, summarize experimental assays are currently available for assessment ICD in vitro vivo, formulate guidelines their interpretation.

Language: Английский

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Energy-stress-mediated AMPK activation inhibits ferroptosis

Nature Cell Biology, Journal Year: 2020, Volume and Issue: 22(2), P. 225 - 234

Published: Feb. 1, 2020

Language: Английский

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Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State

Cell chemical biology, Journal Year: 2019, Volume and Issue: 26(3), P. 420 - 432.e9

Published: Jan. 27, 2019

Language: Английский

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