LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP

Molecular Cell, Journal Year: 2020, Volume and Issue: 80(4), P. 578 - 591.e5

Published: Nov. 1, 2020

Language: Английский

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Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 151, P. 113125 - 113125

Published: May 24, 2022

Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic stroke damage. After acute stroke, the sudden reduction in cerebral blood flow most initially followed by ion transport protein dysfunction and disruption of homeostasis, which turn leads impaired glutamate release, reuptake, excessive N-methyl-D-aspartate receptor (NMDAR) activation, promoting neuronal death. Despite extensive evidence from preclinical studies suggesting that NMDAR stimulation during a central step post-stroke damage, blockers have failed translate into clinical treatment. Current treatment options for are very limited, there therefore great need develop new targets neuroprotective therapeutic agents extend time window. In this review, we highlight recent findings on reuptake mechanisms, its downstream cellular signaling pathways post-ischemic review pathological changes each link help viable targets. We then also summarize potential drugs approaches these stroke.

Language: Английский

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A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo

Neuron, Journal Year: 2021, Volume and Issue: 110(5), P. 770 - 782.e5

Published: Dec. 22, 2021

Language: Английский

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Vascular mechanotransduction

Physiological Reviews, Journal Year: 2023, Volume and Issue: 103(2), P. 1247 - 1421

Published: Jan. 5, 2023

This review aims to survey the current state of mechanotransduction in vascular smooth muscle cells (VSMCs) and endothelial (ECs), including their sensing mechanical stimuli transduction signals that result acute functional modulation longer-term transcriptomic epigenetic regulation blood vessels. The mechanosensors discussed include ion channels, plasma membrane-associated structures receptors, junction proteins. mechanosignaling pathways presented cytoskeleton, integrins, extracellular matrix, intracellular signaling molecules. These are followed by discussions on transcriptome epigenetics, relevance health disease, interactions between VSMCs ECs. Throughout this review, we offer suggestions for specific topics require further understanding. In closing section conclusions perspectives, summarize what is known point out need treat vasculature as a system, not only ECs but also matrix other types such resident macrophages pericytes, so can fully understand physiology pathophysiology vessel whole, thus enhancing comprehension, diagnosis, treatment, prevention diseases.

Language: Английский

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The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling

Nature Immunology, Journal Year: 2022, Volume and Issue: 23(2), P. 287 - 302

Published: Feb. 1, 2022

Language: Английский

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