Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine

Science, Journal Year: 2016, Volume and Issue: 351(6275), P. 858 - 863

Published: Jan. 29, 2016

Dietary antigens are normally rendered nonimmunogenic through a poorly understood "oral tolerance" mechanism that involves immunosuppressive regulatory T (Treg) cells, especially Treg cells induced from conventional in the periphery (pTreg cells). Although orally introducing nominal protein is known to induce such pTreg whether typical diet induces population of under normal conditions thus far has been unknown. By using germ-free mice raised and bred on an elemental devoid dietary antigens, we demonstrated conditions, vast majority small intestinal by solid foods. Moreover, these have limited life span, distinguishable microbiota-induced repress underlying strong immunity ingested antigens.

Language: Английский

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Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis

Cell Host & Microbe, Journal Year: 2022, Volume and Issue: 30(3), P. 289 - 300

Published: March 1, 2022

Language: Английский

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c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

Nature, Journal Year: 2018, Volume and Issue: 554(7692), P. 373 - 377

Published: Feb. 1, 2018

Language: Английский

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Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

Immunity, Journal Year: 2019, Volume and Issue: 50(2), P. 493 - 504.e7

Published: Feb. 1, 2019

Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored phenotype and development. We used single-cell RNA-seq to characterize 35,000 CD4+ regulatory (Treg) memory (Tmem) T in mouse skin colon, their respective draining lymph nodes (LNs) spleen. In these tissues, we identified Treg cell subpopulations distinct degrees NLT phenotype. Subpopulation pseudotime ordering gene kinetics were consistent recruitment yet the initial NLT-priming LNs final stages functional adaptation reflected tissue-specific differences. Predicted recapitulated using an vivo melanoma-induction model, validating key regulators receptors. Finally, profiled human blood Tmem cells, cross-mammalian conserved tissue signatures. summary, describe relationship between heterogeneity NLTs through combined use computational prediction validation.

Language: Английский

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Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice

Immunity, Journal Year: 2019, Volume and Issue: 50(1), P. 212 - 224.e4

Published: Jan. 1, 2019

Language: Английский

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