Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase DOI
Georg Petzold, Eric S. Fischer, Nicolas H. Thomä

et al.

Nature, Journal Year: 2016, Volume and Issue: 532(7597), P. 127 - 130

Published: Feb. 23, 2016

Language: Английский

The multifaceted roles of fatty acid synthesis in cancer DOI
Florian Röhrig, Almut Schulze

Nature reviews. Cancer, Journal Year: 2016, Volume and Issue: 16(11), P. 732 - 749

Published: Sept. 23, 2016

Language: Английский

Citations

1294
Ubiquitin Ligases: Structure, Function, and Regulation DOI
Ning Zheng, Nitzan Shabek

Annual Review of Biochemistry, Journal Year: 2017, Volume and Issue: 86(1), P. 129 - 157

Published: April 4, 2017

Ubiquitin E3 ligases control every aspect of eukaryotic biology by promoting protein ubiquitination and degradation. At the end a three-enzyme cascade, ubiquitin mediate transfer from an E2 ubiquitin-conjugating enzyme to specific substrate proteins. Early investigations E3s RING (really interesting new gene) HECT (homologous E6AP carboxyl terminus) types shed light on their enzymatic activities, general architectures, degron-binding modes. Recent studies have provided deeper mechanistic insights into catalysis, activation, regulation. In this review, we summarize current progress in structure-function as well exciting discoveries novel classes diverse recognition mechanisms. Our increased understanding ligase function regulation has rationale for developing E3-targeting therapeutics treatment human diseases.

Language: Английский

Citations

1209
Induced protein degradation: an emerging drug discovery paradigm DOI

Ashton C. Lai,

Craig M. Crews

Nature Reviews Drug Discovery, Journal Year: 2016, Volume and Issue: 16(2), P. 101 - 114

Published: Nov. 25, 2016

Language: Английский

Citations

1205
Transcriptional Addiction in Cancer DOI Creative Commons

James E. Bradner,

Denes Hnisz,

Richard A. Young

et al.

Cell, Journal Year: 2017, Volume and Issue: 168(4), P. 629 - 643

Published: Feb. 1, 2017

Language: Английский

Citations

1036
Structural basis of PROTAC cooperative recognition for selective protein degradation DOI
Morgan S. Gadd, Andrea Testa, Xavier Lucas

et al.

Nature Chemical Biology, Journal Year: 2017, Volume and Issue: 13(5), P. 514 - 521

Published: March 13, 2017

Language: Английский

Citations

984
YY1 Is a Structural Regulator of Enhancer-Promoter Loops DOI Creative Commons

Abraham S. Weintraub,

Charles H. Li,

Alicia V. Zamudio

et al.

Cell, Journal Year: 2017, Volume and Issue: 171(7), P. 1573 - 1588.e28

Published: Dec. 1, 2017

Language: Английский

Citations

920
The dTAG system for immediate and target-specific protein degradation DOI
Behnam Nabet, Justin M. Roberts, Dennis L. Buckley

et al.

Nature Chemical Biology, Journal Year: 2018, Volume and Issue: 14(5), P. 431 - 441

Published: March 26, 2018

Language: Английский

Citations

876
Proteasome inhibitors in cancer therapy DOI

Elisabet E. Manasanch,

Robert Z. Orlowski

Nature Reviews Clinical Oncology, Journal Year: 2017, Volume and Issue: 14(7), P. 417 - 433

Published: Jan. 24, 2017

Language: Английский

Citations

865
Proteome-wide covalent ligand discovery in native biological systems DOI
Keriann M. Backus, Bruno E. Correia, Kenneth M. Lum

et al.

Nature, Journal Year: 2016, Volume and Issue: 534(7608), P. 570 - 574

Published: June 14, 2016

Language: Английский

Citations

815
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery DOI Creative Commons
George M. Burslem, Craig M. Crews

Cell, Journal Year: 2020, Volume and Issue: 181(1), P. 102 - 114

Published: Jan. 16, 2020

Language: Английский

Citations

785