Journal of the American Chemical Society,
Journal Year:
2018,
Volume and Issue:
140(50), P. 17433 - 17438
Published: Dec. 5, 2018
A
strategy
for
the
installation
of
small
alkyl
fragments
onto
pharmaceutically
relevant
aliphatic
structures
has
been
established
via
metallaphotoredox
catalysis.
Herein,
we
report
that
tris(trimethylsilyl)silanol
can
be
employed
as
an
effective
halogen
abstraction
reagent
that,
in
combination
with
photoredox
and
nickel
catalysis,
allows
a
generic
approach
to
Csp3–Csp3
cross-electrophile
coupling.
In
this
study,
demonstrate
variety
drug-like
groups
successfully
coupled
number
commercially
available
electrophiles,
including
methyl
tosylate
strained
cyclic
bromides.
Moreover,
union
two
secondary
carbon
centers,
long-standing
challenge
organic
molecule
construction,
accomplished
wide
array
structural
formats.
Last,
technology
selectively
merged
Csp2–Csp3
aryl–alkyl
couplings
build
systems
highly
modular
fashion.
Angewandte Chemie International Edition,
Journal Year:
2019,
Volume and Issue:
58(41), P. 14615 - 14619
Published: Aug. 7, 2019
Abstract
Incorporation
of
the
CF
3
group
into
arenes
has
found
increasing
importance
in
drug
discovery.
Herein,
we
report
first
photoredox‐catalyzed
cross‐coupling
aryl
thianthrenium
salts
with
a
copper‐based
trifluoromethyl
reagent,
which
enables
site‐selective
late‐stage
trifluoromethylation
arenes.
The
reaction
proceeds
broad
functional
tolerance,
even
for
complex
small
molecules
on
gram
scale.
method
was
further
extended
to
produce
pentafluoroethylated
derivatives.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
34(25)
Published: July 8, 2021
Plastics
are
now
indispensable
in
daily
lives.
However,
the
pollution
from
plastics
is
also
increasingly
becoming
a
serious
environmental
issue.
Recent
years
have
seen
more
sustainable
approaches
and
technologies,
commonly
known
as
upcycling,
to
transform
into
value-added
materials
chemical
feedstocks.
In
this
review,
latest
research
on
upcycling
presented,
with
greater
focus
use
of
renewable
energy
well
selective
methods
repurpose
synthetic
polymers.
First,
thermal
briefly
introduced,
including
redeployment
for
construction
uses,
3D
printing
precursors,
lightweight
materials.
Then,
some
novel
strategies
deconstruct
condensation
polymers
monomers
repolymerization
or
introduce
vulnerable
linkers
make
degradable
discussed.
Subsequently,
review
will
explore
breakthroughs
by
heterogeneous
homogeneous
photocatalysis,
electrocatalysis,
which
versatile
fine
chemicals
while
simultaneously
mitigating
global
climate
change.
addition,
biotechnological
advances
discovery
engineering
microbes
that
can
decompose
presented.
Finally,
current
challenges
outlook
future
discussed
stimulate
cooperation
field.
ACS Catalysis,
Journal Year:
2018,
Volume and Issue:
9(2), P. 1103 - 1109
Published: Dec. 21, 2018
A
visible-light-mediated
photocatalyzed
protocol
utilizing
copper–phenanthroline-based
catalysts
has
been
developed
that
can
convert
a
large
number
of
olefins
into
their
chlorosulfonylated
products.
Besides
the
Cu(I)
complex
[Cu(dap)2]Cl,
now
well-established
in
photo-ATRA
processes,
corresponding
Cu(II)
[Cu(dap)Cl2]
proved
to
be
often
even
more
efficient
title
reaction,
being
advantageous
from
an
economic
point
view
but
also
opening
up
new
avenues
for
photoredox
catalysis.
Moreover,
copper
complexes
outperformed
commonly
used
ruthenium,
iridium,
or
organic
dye
based
photocatalysts,
owing
ability
stabilize
interact
with
transient
radicals
by
inner
sphere
mechanisms.
The
use
stoichiometric
Na2CO3
combination
photocatalysts
was
found
essential
unactivated
desired
products,
contrast
activated
which
no
additive
required.
As
suggested
appropriate
control
experiments,
role
is
attributed
prevention
poisoning
catalyst.
Journal of the American Chemical Society,
Journal Year:
2020,
Volume and Issue:
142(27), P. 11691 - 11697
Published: June 20, 2020
Alkyl
chlorides
are
bench-stable
chemical
feedstocks
that
remain
among
the
most
underutilized
electrophile
classes
in
transition
metal
catalysis.
Overcoming
intrinsic
limitations
of
C(sp3)–Cl
bond
activation,
we
report
development
a
novel
organosilane
reagent
can
participate
chlorine
atom
abstraction
under
mild
photocatalytic
conditions.
In
particular,
describe
application
this
mechanism
to
dual
nickel/photoredox
catalytic
protocol
enables
first
cross-electrophile
coupling
unactivated
alkyl
and
aryl
chlorides.
Employing
these
low-toxicity,
abundant,
commercially
available
organochloride
building
blocks,
methodology
allows
access
broad
array
highly
functionalized
C(sp2)–C(sp3)
coupled
adducts,
including
numerous
drug
analogues.
Journal of the American Chemical Society,
Journal Year:
2018,
Volume and Issue:
140(50), P. 17433 - 17438
Published: Dec. 5, 2018
A
strategy
for
the
installation
of
small
alkyl
fragments
onto
pharmaceutically
relevant
aliphatic
structures
has
been
established
via
metallaphotoredox
catalysis.
Herein,
we
report
that
tris(trimethylsilyl)silanol
can
be
employed
as
an
effective
halogen
abstraction
reagent
that,
in
combination
with
photoredox
and
nickel
catalysis,
allows
a
generic
approach
to
Csp3–Csp3
cross-electrophile
coupling.
In
this
study,
demonstrate
variety
drug-like
groups
successfully
coupled
number
commercially
available
electrophiles,
including
methyl
tosylate
strained
cyclic
bromides.
Moreover,
union
two
secondary
carbon
centers,
long-standing
challenge
organic
molecule
construction,
accomplished
wide
array
structural
formats.
Last,
technology
selectively
merged
Csp2–Csp3
aryl–alkyl
couplings
build
systems
highly
modular
fashion.
