Parvalbumin+and Npas1+Pallidal Neurons Have Distinct Circuit Topology and Function DOI Creative Commons
Arin Pamukcu, Qiaoling Cui, Harry S. Xenias

et al.

Journal of Neuroscience, Journal Year: 2020, Volume and Issue: 40(41), P. 7855 - 7876

Published: Aug. 31, 2020

The external globus pallidus (GPe) is a critical node within the basal ganglia circuit. Phasic changes in activity of GPe neurons during movement and their alterations Parkinson's disease (PD) argue that important motor control. Parvalbumin-positive (PV + ) Npas1 are two principal neuron classes GPe. distinct electrophysiological properties axonal projection patterns these serve different roles regulating output. However, causal relationship between remains to be established. Here, by using optogenetic approaches mice (both males females), we showed PV promoted suppressed locomotion, respectively. Moreover, under synaptic influences from subthalamic nucleus (STN). Additionally, found selective weakening STN inputs chronic 6-hydroxydopamine lesion model PD. This finding reinforces idea reciprocally connected GPe–STN network plays key role symptomatology thus provides basis for future circuit-based therapies. SIGNIFICANCE STATEMENT pallidum key, yet an understudied component ganglia. Neural goes awry neurologic diseases, such as disease. While this strongly argues control, it has been difficult establish pallidal function/dysfunction. was part because cellular complexity pallidum. types have opposing In addition, described differences influence. Importantly, our research new insights into circuit mechanisms explain hypokinetic features

Language: Английский

Dual electrical stimulation at spinal-muscular interface reconstructs spinal sensorimotor circuits after spinal cord injury DOI Creative Commons
Kai Zhou, Wei Wei, Dan Yang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 19, 2024

Abstract The neural signals produced by varying electrical stimulation parameters lead to characteristic circuit responses. However, the characteristics of circuits reconstructed remain poorly understood, which greatly limits application such neuromodulation techniques for treatment spinal cord injury. Here, we develop a dual system that combines epidural and muscle mimic feedforward feedback in sensorimotor circuits. We demonstrate stimulus frequency 10−20 Hz under conditions is required structural functional reconstruction circuits, not only activates genes associated with axonal regeneration motoneurons, but also improves excitability neurons. Overall, results provide insights into signal decoding during reconstruction, suggesting combination promising method

Language: Английский

Citations

10
Spinal projecting neurons in rostral ventromedial medulla co-regulate motor and sympathetic tone DOI
Zicong Zhang, Junfeng Su, Jing Tang

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(13), P. 3427 - 3444.e21

Published: May 10, 2024

Language: Английский

Citations

10
Cortico-basal ganglia plasticity in motor learning DOI Creative Commons
Richard H. Roth, Jun Ding

Neuron, Journal Year: 2024, Volume and Issue: 112(15), P. 2486 - 2502

Published: July 12, 2024

Language: Английский

Citations

9
Widespread innervation of motoneurons by spinal V3 neurons globally amplifies locomotor output in mice DOI Creative Commons
Han Zhang, Dylan Deska‐Gauthier, Colin Mackay

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(1), P. 115212 - 115212

Published: Jan. 1, 2025

Language: Английский

Citations

1
Parvalbumin+and Npas1+Pallidal Neurons Have Distinct Circuit Topology and Function DOI Creative Commons
Arin Pamukcu, Qiaoling Cui, Harry S. Xenias

et al.

Journal of Neuroscience, Journal Year: 2020, Volume and Issue: 40(41), P. 7855 - 7876

Published: Aug. 31, 2020

The external globus pallidus (GPe) is a critical node within the basal ganglia circuit. Phasic changes in activity of GPe neurons during movement and their alterations Parkinson's disease (PD) argue that important motor control. Parvalbumin-positive (PV + ) Npas1 are two principal neuron classes GPe. distinct electrophysiological properties axonal projection patterns these serve different roles regulating output. However, causal relationship between remains to be established. Here, by using optogenetic approaches mice (both males females), we showed PV promoted suppressed locomotion, respectively. Moreover, under synaptic influences from subthalamic nucleus (STN). Additionally, found selective weakening STN inputs chronic 6-hydroxydopamine lesion model PD. This finding reinforces idea reciprocally connected GPe–STN network plays key role symptomatology thus provides basis for future circuit-based therapies. SIGNIFICANCE STATEMENT pallidum key, yet an understudied component ganglia. Neural goes awry neurologic diseases, such as disease. While this strongly argues control, it has been difficult establish pallidal function/dysfunction. was part because cellular complexity pallidum. types have opposing In addition, described differences influence. Importantly, our research new insights into circuit mechanisms explain hypokinetic features

Language: Английский

Citations

68