Angewandte Chemie International Edition,
Journal Year:
2019,
Volume and Issue:
59(5), P. 1956 - 1960
Published: Nov. 7, 2019
Site-selective
functionalization
of
C-H
bonds
in
small
complex
molecules
is
a
long-standing
challenge
organic
chemistry.
Herein,
we
report
broadly
applicable
and
site-selective
aromatic
dibenzothiophenylation
reaction.
The
conceptual
advantage
this
transformation
further
demonstrated
through
the
two-step
[18
F]fluorination
series
marketed
small-molecule
drugs.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(2), P. 1925 - 2016
Published: Sept. 29, 2021
The
fields
of
C–H
functionalization
and
photoredox
catalysis
have
garnered
enormous
interest
utility
in
the
past
several
decades.
Many
different
scientific
disciplines
relied
on
strategies
including
natural
product
synthesis,
drug
discovery,
radiolabeling,
bioconjugation,
materials,
fine
chemical
synthesis.
In
this
Review,
we
highlight
use
reactions.
We
separate
review
into
inorganic/organometallic
catalysts
organic-based
catalytic
systems.
Further
subdivision
by
reaction
class─either
sp2
or
sp3
functionalization─lends
perspective
tactical
for
these
methods
synthetic
applications.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(6), P. 5682 - 5841
Published: Oct. 18, 2021
Transition-metal-catalyzed
C–H
activation
has
developed
a
contemporary
approach
to
the
omnipresent
area
of
retrosynthetic
disconnection.
Scientific
researchers
have
been
tempted
take
help
this
methodology
plan
their
synthetic
discourses.
This
paradigm
shift
helped
in
development
industrial
units
as
well,
making
synthesis
natural
products
and
pharmaceutical
drugs
step-economical.
In
vast
zone
bond
activation,
functionalization
proximal
bonds
gained
utmost
popularity.
Unlike
bonds,
distal
is
more
strenuous
requires
distinctly
specialized
techniques.
review,
we
compiled
various
methods
adopted
functionalize
mechanistic
insights
within
each
these
procedures,
scope
methodology.
With
give
complete
overview
expeditious
progress
made
field
organic
chemistry
while
also
highlighting
its
pitfalls,
thus
leaving
open
for
further
modifications.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(2), P. 2487 - 2649
Published: Nov. 9, 2021
Redox
processes
are
at
the
heart
of
synthetic
methods
that
rely
on
either
electrochemistry
or
photoredox
catalysis,
but
how
do
and
catalysis
compare?
Both
approaches
provide
access
to
high
energy
intermediates
(e.g.,
radicals)
enable
bond
formations
not
constrained
by
rules
ionic
2
electron
(e)
mechanisms.
Instead,
they
1e
mechanisms
capable
bypassing
electronic
steric
limitations
protecting
group
requirements,
thus
enabling
chemists
disconnect
molecules
in
new
different
ways.
However,
while
providing
similar
intermediates,
differ
several
physical
chemistry
principles.
Understanding
those
differences
can
be
key
designing
transformations
forging
disconnections.
This
review
aims
highlight
these
similarities
between
comparing
their
underlying
principles
describing
impact
electrochemical
photochemical
methods.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Feb. 6, 2020
Can
organic
chemistry
mimic
nature
in
efficiency
and
sustainability?
Not
yet,
but
recent
developments
photoredox
catalysis
animated
the
synthetic
field,
providing
greener
opportunities
for
industry
academia.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
50(2), P. 766 - 897
Published: Dec. 22, 2020
Recent
developments
and
future
prospects
of
visible-light
photocatalysis
in
the
late-stage
functionalization
pharmaceuticals
natural
bioactive
compounds.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(8), P. 4237 - 4352
Published: Jan. 24, 2023
The
emergence
of
modern
photocatalysis,
characterized
by
mildness
and
selectivity,
has
significantly
spurred
innovative
late-stage
C–H
functionalization
approaches
that
make
use
low
energy
photons
as
a
controllable
source.
Compared
to
traditional
strategies,
photocatalysis
paves
the
way
toward
complementary
and/or
previously
unattainable
regio-
chemoselectivities.
Merging
compelling
benefits
with
workflow
offers
potentially
unmatched
arsenal
tackle
drug
development
campaigns
beyond.
This
Review
highlights
photocatalytic
strategies
small-molecule
drugs,
agrochemicals,
natural
products,
classified
according
targeted
bond
newly
formed
one.
Emphasis
is
devoted
identifying,
describing,
comparing
main
mechanistic
scenarios.
draws
critical
comparison
between
established
ionic
chemistry
photocatalyzed
radical-based
manifolds.
aims
establish
current
state-of-the-art
illustrate
key
unsolved
challenges
be
addressed
in
future.
authors
aim
introduce
general
readership
functionalization,
specialist
practitioners
evaluation
methodologies,
potential
for
improvement,
future
uncharted
directions.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(6), P. 2399 - 2414
Published: Jan. 27, 2022
Late-stage
functionalization
of
C-H
bonds
(C-H
LSF)
can
provide
a
straightforward
approach
to
the
efficient
synthesis
functionalized
complex
molecules.
However,
LSF
is
challenging
because
bond
must
be
in
presence
various
other
functional
groups.
In
this
Perspective,
we
evaluate
aromatic
on
basis
four
criteria─reactivity,
chemoselectivity,
site-selectivity,
and
substrate
scope─and
our
own
views
current
challenges
as
well
promising
strategies
areas
growth
going
forward.
Science,
Journal Year:
2021,
Volume and Issue:
372(6545), P. 984 - 989
Published: May 27, 2021
We
investigated
genome
folding
across
the
eukaryotic
tree
of
life.
find
two
types
three-dimensional
(3D)
architectures
at
chromosome
scale.
Each
type
appears
and
disappears
repeatedly
during
evolution.
The
architecture
that
an
organism
exhibits
correlates
with
absence
condensin
II
subunits.
Moreover,
depletion
converts
human
to
a
state
resembling
seen
in
organisms
such
as
fungi
or
mosquitoes.
In
this
state,
centromeres
cluster
together
nucleoli,
heterochromatin
domains
merge.
propose
physical
model
which
lengthwise
compaction
chromosomes
by
mitosis
determines
chromosome-scale
architecture,
effects
are
retained
subsequent
interphase.
This
mechanism
likely
has
been
conserved
since
last
common
ancestor
all
eukaryotes.
ACS Catalysis,
Journal Year:
2021,
Volume and Issue:
11(7), P. 3891 - 3915
Published: March 15, 2021
Multicatalysis
is
an
emerging
field
targeting
the
development
of
efficient
catalytic
transformations
to
quickly
convert
relatively
simple
starting
materials
into
more
complex
value-added
products.
Within
multicatalytic
processes
either
multiple
catalysts
execute
single
reactions
or
precise
sequences
occur
in
a
"one-pot"
fashion.
Attractively,
protocols
not
only
enable
that
are
inaccessible
through
classic
approaches
but
also
able
significantly
reduce
time,
waste,
and
cost
synthetic
processes,
making
organic
synthesis
resources
efficient.
In
this
Perspective
article,
we
review
different
strategies
multicatalysis
bring
distinct
challenges
opportunities.
We
divide
overarching
three
main
categories:
cooperative,
domino,
relay
catalysis.
Each
category
described
along
with
representative
examples
highlight
its
features.
Special
emphasis
dedicated
catalysis,
which
further
discussed
subcategories.
Lastly,
provide
analysis
systems
incorporate
higher
levels
complexity
underscore
potential
systems.