Photoinduced copper-catalysed asymmetric amidation via ligand cooperativity

Nature, Journal Year: 2021, Volume and Issue: 596(7871), P. 250 - 256

Published: June 28, 2021

Language: Английский

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Enantioselective radical C–H amination for the synthesis of β-amino alcohols

Nature Chemistry, Journal Year: 2020, Volume and Issue: 12(8), P. 697 - 704

Published: June 22, 2020

Language: Английский

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Photoinduced Copper-Catalyzed Asymmetric C–O Cross-Coupling

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(33), P. 13382 - 13392

Published: Aug. 10, 2021

The construction of carbon–heteroatom bonds is one the most active areas research in organic chemistry because function molecules often derived from presence heteroatoms. Although considerable advances have recently been achieved radical-involved catalytic asymmetric C–N bond formation, there has little progress corresponding C–O bond-forming processes. Here, we describe a photoinduced copper-catalyzed cross-coupling readily available oxime esters and 1,3-dienes to generate diversely substituted allylic with high regio- enantioselectivity (>75 examples; up 95% ee). reaction proceeds at room temperature under excitation by purple light-emitting diodes (LEDs) features use single, earth-abundant copper-based chiral catalyst as both photoredox for radical generation source induction coupling. Combined experimental density functional theory (DFT) computational studies suggest formation π-allylcopper complexes redox-active bifunctional reagents through radical–polar crossover process.

Language: Английский

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The Merger of Photoredox and Cobalt Catalysis

Trends in Chemistry, Journal Year: 2020, Volume and Issue: 2(5), P. 410 - 426

Published: Feb. 13, 2020

Language: Английский

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A review of enantioselective dual transition metal/photoredox catalysis

Science China Chemistry, Journal Year: 2020, Volume and Issue: 63(5), P. 637 - 647

Published: April 1, 2020

Language: Английский

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