Synergy between amyloid-β and tau in Alzheimer’s disease

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(10), P. 1183 - 1193

Published: Aug. 10, 2020

Language: Английский

---

Negative feedback control of neuronal activity by microglia

Nature, Journal Year: 2020, Volume and Issue: 586(7829), P. 417 - 423

Published: Sept. 30, 2020

Language: Английский

---

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Medicinal Research Reviews, Journal Year: 2021, Volume and Issue: 42(1), P. 259 - 305

Published: May 6, 2021

Abstract Ischemic stroke caused by arterial occlusion is the most common type of stroke, which among frequent causes disability and death worldwide. Current treatment approaches involve achieving rapid reperfusion either pharmacologically or surgically, both are time‐sensitive; moreover, blood flow recanalization often ischemia/reperfusion injury. However, even though neuroprotective intervention urgently needed in event exact mechanisms neuronal during ischemic still unclear, consequently, capacity for drug development has remained limited. Multiple cell pathways implicated pathogenesis stroke. Here, we have reviewed these potential pathways, including intrinsic extrinsic apoptosis, necroptosis, autophagy, ferroptosis, parthanatos, phagoptosis, pyroptosis. We also latest results pharmacological studies on summarized emerging targets with a focus clinical trials. These observations may help to further understand pathological events bridge gap between basic translational research reveal novel interventions.

Language: Английский

---

Microglia: Immune and non-immune functions

Immunity, Journal Year: 2021, Volume and Issue: 54(10), P. 2194 - 2208

Published: Oct. 1, 2021

Language: Английский

---

The semantics of microglia activation: neuroinflammation, homeostasis, and stress

Journal of Neuroinflammation, Journal Year: 2021, Volume and Issue: 18(1)

Published: Nov. 6, 2021

Microglia are emerging as critical regulators of neuronal function and behavior in nearly every area neuroscience. Initial reports focused on classical immune functions microglia pathological contexts, however, immunological concepts from these studies have been applied to describe neuro-immune interactions the absence disease, injury, or infection. Indeed, terms such 'microglia activation' 'neuroinflammation' used ubiquitously changes disparate contexts; particularly stress research, where prompt undue comparisons conditions. This creates a barrier for investigators new neuro-immunology ultimately hinders our understanding effects microglia. As more seek understand role neurobiology behavior, it is increasingly important develop standard methods study define microglial phenotype function. In this review, we summarize primary research physiological contexts. Further, propose framework better microglia1 chronic stress. approach will enable precise characterization different which should facilitate development microglia-directed therapeutics psychiatric neurological disease.

Language: Английский

---

Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Sept. 22, 2023

Abstract Microglia activation is observed in various neurodegenerative diseases. Recent advances single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity. Some identified specific states correlate pathological hallmarks are associated functions. both exert protective function by phagocytosing clearing protein aggregates play detrimental roles due to excessive uptake of aggregates, which would lead microglial phagocytic ability impairment, neuroinflammation, eventually neurodegeneration. In addition, peripheral immune cells infiltration shapes into a pro-inflammatory phenotype accelerates disease progression. also act as mobile vehicle propagate aggregates. Extracellular vesicles released from autophagy impairment all contribute progression Thus, enhancing phagocytosis, reducing microglial-mediated inhibiting exosome synthesis secretion, promoting conversion considered be promising strategies for the therapy Here we comprehensively review biology diseases, including Alzheimer’s disease, Parkinson’s multiple system atrophy, amyotrophic lateral sclerosis, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration, dementia Lewy bodies Huntington’s disease. We summarize possible microglia-targeted interventions treatments against diseases preclinical clinical evidence cell experiments, animal studies, trials.

Language: Английский

---

Microglia and Central Nervous System–Associated Macrophages—From Origin to Disease Modulation

Annual Review of Immunology, Journal Year: 2021, Volume and Issue: 39(1), P. 251 - 277

Published: Feb. 9, 2021

The immune system of the central nervous (CNS) consists primarily innate cells. These are highly specialized macrophages found either in parenchyma, called microglia, or at CNS interfaces, such as leptomeningeal, perivascular, and choroid plexus macrophages. While they were thought phagocytes, their function extends well beyond simple removal cell debris during development diseases. Brain-resident cells to be plastic, long-lived, host an outstanding number risk genes for multiple pathologies. As a result, now considered most suitable targets modulating Additionally, recent single-cell technologies enhanced our molecular understanding origins, fates, interactomes, functional statesduring health perturbation. Here, we review current state challenges myeloid biology treatment options related

Language: Английский

---

Crosstalk Between Astrocytes and Microglia: An Overview

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: July 16, 2020

Based on discoveries enabled by new technologies and analyzed using novel computational tools, neuroscience can be re-conceived in terms of information exchange dense networks intercellular connections rather than the context individual populations, such as glia or neurons.. Cross-talk between neurons microglia astrocytes are has been addressed, however, manner which non-neuronal cells communicate interact remains less well understood. We review this intriguing crosstalk among CNS cells, focusing how it contributes to brain development two neurodegenerative diseases: Alzheimer disease GRN-FTLD most prevalent tumor, astrocytoma. The goal studying these communications is promote our ability combat incurable neurological disorders.

Language: Английский

---

Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases

Science, Journal Year: 2020, Volume and Issue: 370(6512), P. 66 - 69

Published: Oct. 2, 2020

Dementia is a rapidly rising global health crisis that silently disables families and ends lives livelihoods around the world. To date, however, no early biomarkers or effective therapies exist. It now clear brain microglia are more than mere bystanders amyloid phagocytes; they can act as governors of neuronal function homeostasis in adult brain. Here, we highlight fundamental role tissue-resident macrophages health. Then, suggest how chronic impairment microglia-neuron cross-talk may secure permanence failure synaptic Alzheimer's Parkinson's diseases. Understanding to assess modulate interactions critical for will be key developing dementia.

Language: Английский

---

Tissue-specific macrophages: how they develop and choreograph tissue biology

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(9), P. 563 - 579

Published: March 15, 2023

Macrophages are innate immune cells that form a 3D network in all our tissues, where they phagocytose dying and cell debris, complexes, bacteria other waste products. Simultaneously, produce growth factors signalling molecules — such activities not only promote host protection response to invading microorganisms but also crucial for organ development homeostasis. There is mounting evidence of macrophages orchestrating fundamental physiological processes, as blood vessel formation, adipogenesis, metabolism central peripheral neuronal function. In parallel, novel methodologies have led the characterization tissue-specific macrophages, with distinct subpopulations these showing different developmental trajectories, transcriptional programmes life cycles. Here, we summarize growing knowledge macrophage diversity how subsets orchestrate tissue We further interrelate ontogeny their core functions across is, events within niche may control functionality during development, homeostasis ageing. Finally, highlight open questions will need be addressed by future studies better understand subsets. important immunity infections clearing products from maintain health regulating metabolism, many biological processes. Elvira Mass co-workers discuss populations found throughout body, highlighting shared unique aspects functions.

Language: Английский

---