Gabaergic Interneurons in Early Brain Development: Conducting and Orchestrated by Cortical Network Activity DOI Creative Commons

Davide Warm,

Jonas Schroer,

Anne Sinning

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: Jan. 3, 2022

Throughout early phases of brain development, the two main neural signaling mechanisms-excitation and inhibition-are dynamically sculpted in neocortex to establish primary functions. Despite its relatively late formation persistent developmental changes, GABAergic system promotes ordered shaping neuronal circuits at structural functional levels. Within this frame, interneurons participate first spontaneous later sensory-evoked activity patterns that precede cortical functions mature brain. Upon their subcortical generation, embryonic must orderly migrate settle respective target layers before they can actively engage network activity. During process, changes molecular synaptic level allow not only coordinated but also pruning connections as well excitatory inhibitory synapses. At postsynaptic site, shift from an towards response is required enable synchronization within networks. Concomitantly, progressive specification different interneuron subtypes endows with distinct local region-specific modulation firing. Finally, apoptotic process further refines populations by constantly maintaining a controlled ratio neurons. Interestingly, many these fundamental complex processes are influenced-if directly controlled-by electrical Interneurons on subcellular, cellular, affected high frequency patterns, such spindle burst gamma oscillations rodents delta brushes humans. Conversely, maturation structure function each scales feeds back contributes generation essential for proper peri- postnatal development. Overall, more precise description conducting role terms how contribute specific patterns-as impinge orchestra members-will lead better understanding physiological pathophysiological development nervous system.

Language: Английский

Developmental trajectories of EEG aperiodic and periodic components in children 2–44 months of age DOI Creative Commons
Carol L. Wilkinson, Lisa Yankowitz, Jerry Y. Chao

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 10, 2024

Abstract The development of neural circuits has long-lasting effects on brain function, yet our understanding early circuit in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs collected 592 healthy 2–44 month-old infants, revealing age-dependent nonlinear changes suggestive distinct milestones maturation. Developmental peaks include (1) the presence then absence a 9-10 Hz alpha peak between 2-6 months, (2) high beta (20-30 Hz) 4-18 (3) emergence low (12-20 some infants after six months age. We hypothesized that may reflect maturation thalamocortical network development. Infant anesthesia studies observe GABA-modulating anesthetics do not induce mediated frontal coherence until 10-12 Using small cohort ( n = 23) with before during anesthesia, we provide preliminary evidence have higher anesthesia-induced compared to those without peak.

Language: Английский

Citations

14
Modulation of neuronal activity in cortical organoids with bioelectronic delivery of ions and neurotransmitters DOI Creative Commons
Yunjeong Park, Sebastian Hernandez,

Cristian O. Hernandez

et al.

Cell Reports Methods, Journal Year: 2024, Volume and Issue: 4(1), P. 100686 - 100686

Published: Jan. 1, 2024

Precise modulation of brain activity is fundamental for the proper establishment and maturation cerebral cortex. To this end, cortical organoids are promising tools to study circuit formation underpinnings neurodevelopmental disease. However, ability manipulate neuronal with high temporal resolution in remains limited. overcome challenge, we introduce a bioelectronic approach control organoid selective delivery ions neurotransmitters. Using approach, sequentially increased decreased potassium (K

Language: Английский

Citations

11
Astroglia’s role in synchronized spontaneous neuronal activity: from physiology to pathology DOI Creative Commons

Aswathy Ammothumkandy,

Alisha Cayce,

Mohammad Shariq

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 19, 2025

The nervous system relies on a balance of excitatory and inhibitory signals. Aberrant neuronal hyperactivity is pathological phenotype associated with several neurological disorders, its most severe effects observed in epilepsy patients. This review explores the literature spontaneous synchronized activity, physiological role, aberrant forms disease. Emphasizing importance targeting underlying disease mechanisms beyond traditional neuron-focused therapies, delves into role astroglia progression. We detail how transitions from normal to state, leading epileptogenic seizures cognitive decline. Astroglia activity correlated epileptiform both animal models human tissue, indicating their potential seizure induction modulation. Understanding astroglia's dual beneficial detrimental roles could lead novel treatments for other disorders as substrate.

Language: Английский

Citations

1
Early development of sleep and brain functional connectivity in term-born and preterm infants DOI
Julie Uchitel, Sampsa Vanhatalo, Topun Austin

et al.

Pediatric Research, Journal Year: 2021, Volume and Issue: 91(4), P. 771 - 786

Published: April 15, 2021

Language: Английский

Citations

51
Gabaergic Interneurons in Early Brain Development: Conducting and Orchestrated by Cortical Network Activity DOI Creative Commons

Davide Warm,

Jonas Schroer,

Anne Sinning

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: Jan. 3, 2022

Throughout early phases of brain development, the two main neural signaling mechanisms-excitation and inhibition-are dynamically sculpted in neocortex to establish primary functions. Despite its relatively late formation persistent developmental changes, GABAergic system promotes ordered shaping neuronal circuits at structural functional levels. Within this frame, interneurons participate first spontaneous later sensory-evoked activity patterns that precede cortical functions mature brain. Upon their subcortical generation, embryonic must orderly migrate settle respective target layers before they can actively engage network activity. During process, changes molecular synaptic level allow not only coordinated but also pruning connections as well excitatory inhibitory synapses. At postsynaptic site, shift from an towards response is required enable synchronization within networks. Concomitantly, progressive specification different interneuron subtypes endows with distinct local region-specific modulation firing. Finally, apoptotic process further refines populations by constantly maintaining a controlled ratio neurons. Interestingly, many these fundamental complex processes are influenced-if directly controlled-by electrical Interneurons on subcellular, cellular, affected high frequency patterns, such spindle burst gamma oscillations rodents delta brushes humans. Conversely, maturation structure function each scales feeds back contributes generation essential for proper peri- postnatal development. Overall, more precise description conducting role terms how contribute specific patterns-as impinge orchestra members-will lead better understanding physiological pathophysiological development nervous system.

Language: Английский

Citations

37