Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(2)
Published: Feb. 19, 2024
Unlike
most
cancer
types,
the
incidence
of
esophageal
adenocarcinoma
(EAC)
has
rapidly
escalated
in
western
world
over
recent
decades.
Using
whole
genome
bisulfite
sequencing
(WGBS),
we
identify
transcription
factor
(TF)
FOXM1
as
an
important
epigenetic
regulator
EAC.
plays
a
critical
role
cellular
proliferation
and
tumor
growth
EAC
patient-derived
organoids
cell
line
models.
We
ERBB2
upstream
expression
transcriptional
activity
FOXM1.
Unexpectedly,
gene
set
enrichment
analysis
(GSEA)
unbiased
screen
reveals
prominent
anti-correlation
between
immune
response
pathways.
Indeed,
syngeneic
mouse
models
show
that
inhibits
infiltration
CD8
Gut,
Journal Year:
2024,
Volume and Issue:
73(6), P. 897 - 909
Published: March 29, 2024
Barrett’s
oesophagus
is
the
only
known
precursor
to
oesophageal
adenocarcinoma,
a
cancer
with
very
poor
prognosis.
The
main
risk
factors
for
are
history
of
gastro-oesophageal
acid
reflux
symptoms
and
obesity.
Men,
smokers
those
family
also
at
increased
risk.
Progression
from
occurs
via
an
intermediate
stage,
as
dysplasia.
However,
dysplasia
early
usually
develop
without
any
clinical
signs,
often
in
individuals
whose
well
controlled
by
suppressant
medications;
therefore,
endoscopic
surveillance
recommended
allow
diagnosis
timely
intervention.
Individuals
need
be
fully
informed
about
implications
this
benefits
risks
monitoring
strategies.
Pharmacological
treatments
control
symptoms,
but
not
chemoprevention.
Dysplasia
stage
1
adenocarcinoma
have
excellent
prognoses,
since
they
can
cured
or
surgical
therapies.
Endoscopic
resection
most
accurate
staging
technique
Barrett’s-related
adenocarcinoma.
ablation
effective
indicated
eradicate
patients
Future
research
should
focus
on
improved
accuracy
detection
new
technologies
providing
more
robust
evidence
support
pathways
follow-up
treatment.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2021,
Volume and Issue:
unknown
Published: Nov. 27, 2021
Summary
Multiple
distinct
cell
types
of
the
human
lung
and
airways
have
been
defined
by
single
RNA
sequencing
(scRNAseq).
Here
we
present
a
multi-omics
spatial
atlas
to
define
novel
which
map
back
into
macro-
micro-anatomical
tissue
context
functional
microenvironments.
Firstly,
generated
nuclei
sequencing,
VDJ-sequencing
Visium
Spatial
Transcriptomics
data
sets
from
5
different
locations
airways.
Secondly,
additional
types/states,
as
well
spatially
known
airway
types,
such
adult
chondrocytes,
submucosal
gland
(SMG)
duct
cells,
pericyte
smooth
muscle
subtypes,
immune-recruiting
fibroblasts,
peribronchial
perichondrial
peripheral
nerve
associated
fibroblasts
Schwann
cells.
Finally,
survival
niche
for
IgA-secreting
plasma
cells
at
SMG,
comprising
newly
epithelial
SMG-Duct
B
T
lineage
immune
Using
our
transcriptomic
cell-cell
interaction
analysis,
propose
signalling
circuit
that
establishes
supports
this
niche.
Overall,
provide
transcriptional
with
multiple
allows
study
specific
microenvironments
gland-associated
lymphoid
(GALN).
Cancer Discovery,
Journal Year:
2022,
Volume and Issue:
12(7), P. 1642 - 1655
Published: April 9, 2022
Epithelial
stem
cells
accumulate
mutations
throughout
life.
Some
of
these
mutants
increase
competitive
fitness
and
may
form
clones
that
colonize
the
cell
niche
persist
to
acquire
further
genome
alterations.
After
a
transient
expansion,
mutant
must
revert
homeostatic
behavior
so
normal
tissue
architecture
is
maintained.
positively
selected
promote
cancer
development,
whereas
others
inhibit
carcinogenesis.
Factors
shape
mutational
landscape
include
wild-type
dynamics,
competition
for
niche,
environmental
exposures.
Understanding
processes
give
new
insight
into
basis
risk
opportunities
prevention.
Recent
advances
in
sequencing
have
found
somatic
all
epithelial
tissues
studied
date.
Here
we
review
how
epithelia
shaped
by
clonal
within
combined
with
genes
are
oncogenic,
be
inhibitory
transformation.
Discoveries
this
area
leave
many
open
questions,
such
as
definition
driver
genes,
mechanisms
which
constrain
high
proportion
oncogenic
cells,
whether
can
modulated
decrease
risk.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(2), P. 288 - 288
Published: Jan. 9, 2024
Gastroesophageal
(GE)
junction
adenocarcinoma
is
an
aggressive
malignancy
of
growing
incidence
and
associated
with
public
health
issues
such
as
obesity
GERD.
Management
has
evolved
over
the
last
two
decades
to
incorporate
a
multidisciplinary
approach,
including
endoscopic
intervention,
neoadjuvant
chemotherapy/chemoradiation,
minimally
invasive
or
more
limited
surgical
approaches.
Surgical
approaches
include
esophagectomy,
total
gastrectomy,
and,
recently,
proximal
gastrectomy.
This
review
analyzes
evidence
for
applicability
these
varied
in
management,
well
areas
continued
controversy
investigation.
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(2)
Published: Feb. 19, 2024
Unlike
most
cancer
types,
the
incidence
of
esophageal
adenocarcinoma
(EAC)
has
rapidly
escalated
in
western
world
over
recent
decades.
Using
whole
genome
bisulfite
sequencing
(WGBS),
we
identify
transcription
factor
(TF)
FOXM1
as
an
important
epigenetic
regulator
EAC.
plays
a
critical
role
cellular
proliferation
and
tumor
growth
EAC
patient-derived
organoids
cell
line
models.
We
ERBB2
upstream
expression
transcriptional
activity
FOXM1.
Unexpectedly,
gene
set
enrichment
analysis
(GSEA)
unbiased
screen
reveals
prominent
anti-correlation
between
immune
response
pathways.
Indeed,
syngeneic
mouse
models
show
that
inhibits
infiltration
CD8
