Nature,
Journal Year:
2023,
Volume and Issue:
617(7960), P. 386 - 394
Published: April 26, 2023
Abstract
Inflammation
is
a
complex
physiological
process
triggered
in
response
to
harmful
stimuli
1
.
It
involves
cells
of
the
immune
system
capable
clearing
sources
injury
and
damaged
tissues.
Excessive
inflammation
can
occur
as
result
infection
hallmark
several
diseases
2–4
The
molecular
bases
underlying
inflammatory
responses
are
not
fully
understood.
Here
we
show
that
cell
surface
glycoprotein
CD44,
which
marks
acquisition
distinct
phenotypes
context
development,
immunity
cancer
progression,
mediates
uptake
metals
including
copper.
We
identify
pool
chemically
reactive
copper
(ii)
mitochondria
macrophages
catalyses
NAD(H)
redox
cycling
by
activating
hydrogen
peroxide.
Maintenance
NAD
+
enables
metabolic
epigenetic
programming
towards
state.
Targeting
mitochondrial
with
supformin
(LCC-12),
rationally
designed
dimer
metformin,
induces
reduction
pool,
leading
states
oppose
macrophage
activation.
LCC-12
interferes
plasticity
other
settings
reduces
mouse
models
bacterial
viral
infections.
Our
work
highlights
central
role
regulator
unveils
therapeutic
strategy
based
on
reprogramming
control
states.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2023,
Volume and Issue:
42(1)
Published: April 27, 2023
Abstract
Altered
metabolism
is
a
hallmark
of
cancer
and
presents
vulnerability
that
can
be
exploited
in
treatment.
Regulated
cell
death
(RCD)
plays
crucial
role
metabolic
therapy.
A
recent
study
has
identified
new
metabolic-related
RCD
known
as
disulfidptosis.
Preclinical
findings
suggest
therapy
using
glucose
transporter
(GLUT)
inhibitors
trigger
disulfidptosis
inhibit
growth.
In
this
review,
we
summarize
the
specific
mechanisms
underlying
outline
potential
future
research
directions.
We
also
discuss
challenges
may
arise
clinical
translation
research.
Scientific Reports,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: July 5, 2022
Abstract
Increased
intracellular
toxicity
due
to
an
imbalance
in
copper
homeostasis
caused
by
ion
accumulation
could
regulate
the
rate
of
cancer
cell
growth
and
proliferation.
The
goal
this
study
was
create
a
novel
Cuproptosis-related
lncRNA
signature
that
may
be
utilized
predict
survival
immunotherapy
HCC
patients.
Cuproptosis-associated
lncRNAs
differentially
expressed
between
tumor
tissue
normal
were
discovered
first.
By
LASSO-Cox
analysis,
overlapping
then
build
signature,
which
might
used
patient
prognosis
responsiveness
immune
checkpoint
blockade
(ICB)
therapy.
Differences
infiltration
subpopulations
high
low-risk
score
subgroups
also
analyzed.
Moreover,
nomogram
based
on
clinical
features
developed
demonstrated
have
good
predictive
potential.
Finally,
qRT-PCR
performed
HerpG2
MHCC-97H
lines
explore
whether
these
indeed
involved
process
Cuproptosis.
In
summary,
we
created
prognostic
profile
linked
Cuproptosis
forecast
response
immunotherapy,
provide
new
potential
non-apoptotic
therapeutic
perspective
for
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
32(40)
Published: July 30, 2022
Abstract
Cuproptosis
is
a
very
newly
recognized
regulated
cell
death
modality
that
distinct
from
known
mechanisms
and
shows
enormous
prospect
in
cancer
treatment.
However,
its
efficacy
copper‐dependent
restricted
by
strictly
copper
metabolism.
Herein,
novel
copper/iron
hybrid
hollow
amorphous
metal
organic
framework
(HaMOF)
developed
as
an
oxidative
stress
amplifier
metabolic
disrupter
for
synergistic
cuproptosis/ferroptosis/apoptosis
anticancer
therapy.
The
HaMOF
fabricated
Cu
2+
,
3,3′‐dithiobis(propionohydrazide)
Fe
3+
via
unsaturated
coordination‐etching
integration
strategy,
then
doxorubicin
loaded
followed
surface
decoration
with
hyaluronan.
obtained
DOX@Fe/CuTH
exhibits
tumor
microenvironment‐triggered
catalytic
therapeutic
property,
wherein
it
can
amplify
cellular
simultaneously
boosting
H
2
O
production
depleting
glutathione.
Moreover,
cause
mitochondrial
dysfunction
downregulate
the
expressions
of
transporter
ATP7A
iron
FPN
1,
thereby
leading
to
disorders
high
retentions
cytoplasm
•OH
generation.
overloaded
lipoylated
protein
dihydrolipoamide
S‐acetyltransferase
aggregation
lead
cuproptosis.
Collectively,
both
augmented
induce
potent
ferroptosis,
which
synergizes
cuproptosis
DOX‐mediated
apoptosis
efficiently
suppress
growth.
This
bimetallic
nanoplatform
provides
new
paradigm
boost
cuproptosis‐related
therapies.
Nature,
Journal Year:
2023,
Volume and Issue:
617(7960), P. 386 - 394
Published: April 26, 2023
Abstract
Inflammation
is
a
complex
physiological
process
triggered
in
response
to
harmful
stimuli
1
.
It
involves
cells
of
the
immune
system
capable
clearing
sources
injury
and
damaged
tissues.
Excessive
inflammation
can
occur
as
result
infection
hallmark
several
diseases
2–4
The
molecular
bases
underlying
inflammatory
responses
are
not
fully
understood.
Here
we
show
that
cell
surface
glycoprotein
CD44,
which
marks
acquisition
distinct
phenotypes
context
development,
immunity
cancer
progression,
mediates
uptake
metals
including
copper.
We
identify
pool
chemically
reactive
copper
(ii)
mitochondria
macrophages
catalyses
NAD(H)
redox
cycling
by
activating
hydrogen
peroxide.
Maintenance
NAD
+
enables
metabolic
epigenetic
programming
towards
state.
Targeting
mitochondrial
with
supformin
(LCC-12),
rationally
designed
dimer
metformin,
induces
reduction
pool,
leading
states
oppose
macrophage
activation.
LCC-12
interferes
plasticity
other
settings
reduces
mouse
models
bacterial
viral
infections.
Our
work
highlights
central
role
regulator
unveils
therapeutic
strategy
based
on
reprogramming
control
states.
