Structural diversity of the SARS-CoV-2 Omicron spike DOI Creative Commons
S. Gobeil, Rory Henderson, Victoria Stalls

et al.

Molecular Cell, Journal Year: 2022, Volume and Issue: 82(11), P. 2050 - 2068.e6

Published: March 25, 2022

Language: Английский

Considerable escape of SARS-CoV-2 Omicron to antibody neutralization DOI Open Access
Delphine Planas, Nell Saunders, Piet Maes

et al.

Nature, Journal Year: 2021, Volume and Issue: 602(7898), P. 671 - 675

Published: Dec. 23, 2021

Language: Английский

Citations

1456
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift DOI Open Access
Elisabetta Cameroni, John E. Bowen, Laura E. Rosen

et al.

Nature, Journal Year: 2021, Volume and Issue: 602(7898), P. 664 - 670

Published: Dec. 23, 2021

Language: Английский

Citations

1113
The biological and clinical significance of emerging SARS-CoV-2 variants DOI Creative Commons
Kaiming Tao, Philip L. Tzou, Janin Nouhin

et al.

Nature Reviews Genetics, Journal Year: 2021, Volume and Issue: 22(12), P. 757 - 773

Published: Sept. 17, 2021

Language: Английский

Citations

991
Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: a narrative review DOI Creative Commons
Thibault Fiolet, Yousra Kherabi,

Conor-James MacDonald

et al.

Clinical Microbiology and Infection, Journal Year: 2021, Volume and Issue: 28(2), P. 202 - 221

Published: Oct. 27, 2021

Language: Английский

Citations

834
Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum DOI Creative Commons
Chang Liu, Helen M. Ginn, Wanwisa Dejnirattisai

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(16), P. 4220 - 4236.e13

Published: June 17, 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with variants conferring advantage rapidly becoming dominant lineages, e.g., B.1.617. With apparent increased transmissibility, variant B.1.617.2 contributed to the current wave of infection ravaging Indian subcontinent and been designated a concern in United Kingdom. Here we study ability monoclonal antibodies convalescent vaccine sera neutralize B.1.617.1 B.1.617.2, complement this structural analyses Fab/receptor binding domain (RBD) complexes, map antigenic space variants. Neutralization both viruses is reduced compared ancestral Wuhan-related strains, but there no evidence widespread antibody escape as seen B.1.351. However, B.1.351 P.1 showed markedly more reduction neutralization suggesting that individuals infected previously by these may be susceptible reinfection B.1.617.2. This observation provides important new insights for immunization policy future vaccines non-immune populations.

Language: Английский

Citations

713
The immunology and immunopathology of COVID-19 DOI Open Access
Miriam Mérad, Catherine A. Blish, Federica Sallusto

et al.

Science, Journal Year: 2022, Volume and Issue: 375(6585), P. 1122 - 1127

Published: March 10, 2022

Considerable research effort has been made worldwide to decipher the immune response triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, identify drivers of and fatal COVID-19, understand what leads prolongation symptoms after disease resolution. We review results almost years COVID-19 immunology discuss definitive findings remaining questions regarding our understanding pathophysiology. emerging differences in responses seen those with without Long Covid syndrome, also known as post-acute sequelae SARS-CoV-2. hope that knowledge gained from this will be applied studies inflammatory processes involved critical chronic illnesses, which remain a major unmet need.

Language: Английский

Citations

698
SARS-CoV-2 Spike Mutations, L452R, T478K, E484Q and P681R, in the Second Wave of COVID-19 in Maharashtra, India DOI Creative Commons
Sarah Cherian, Varsha Potdar, Santosh Jadhav

et al.

Microorganisms, Journal Year: 2021, Volume and Issue: 9(7), P. 1542 - 1542

Published: July 20, 2021

As the global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic expands, genomic epidemiology and whole genome sequencing are being used to investigate its transmission evolution. Against backdrop of emergence "variants concern" (VOCs) during December 2020 an upsurge in a state western part India since January 2021, analysis spike protein mutations using sequence structural approaches were undertaken identify possible new variants gauge fitness current circulating strains. Phylogenetic revealed that newly identified lineages B.1.617.1 B.1.617.2 predominantly circulating. The signature possessed by these strains L452R, T478K, E484Q, D614G P681R protein, including within receptor-binding domain (RBD). Of these, at residue positions 452, 484 681 have been reported other globally lineages. RBD T478K E484Q may possibly result increased ACE2 binding while furin cleavage site could increase rate S1-S2 cleavage, resulting better transmissibility. two mutations, L452R indicated decreased select monoclonal antibodies (mAbs) affect their neutralization potential. Further vitro/in vivo studies would help confirm phenotypic changes mutant Overall, study emerged responsible for second wave COVID-19 Maharashtra. Lineage has designated as VOC delta variant interest kappa, they widely rest country well globally. Continuous monitoring emerging is essential.

Language: Английский

Citations

631
SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients DOI Creative Commons
Daryl Geers, Marc C. Shamier, Susanne Bogers

et al.

Science Immunology, Journal Year: 2021, Volume and Issue: 6(59)

Published: May 25, 2021

Infection- or vaccination-induced SARS-CoV-2 S–specific CD4 + T cells are indifferent to the S mutations of variants concern.

Language: Английский

Citations

523
Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement DOI Creative Commons
Matthew McCallum,

Nadine Czudnochowski,

Laura E. Rosen

et al.

Science, Journal Year: 2022, Volume and Issue: 375(6583), P. 864 - 868

Published: Feb. 24, 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern evades antibody-mediated immunity that comes from vaccination or infection with earlier variants due to accumulation numerous spike mutations. To understand the antigenic shift, we determined cryo–electron microscopy and x-ray crystal structures protein receptor-binding domain bound broadly neutralizing sarbecovirus monoclonal antibody (mAb) S309 (the parent mAb sotrovimab) human ACE2 receptor. We provide a blueprint for understanding marked reduction binding other therapeutic mAbs leads dampened activity. Remodeling interactions between likely explains enhanced affinity host receptor relative ancestral virus.

Language: Английский

Citations

509
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape DOI Creative Commons
Tyler N. Starr, Nadine Czudnochowski, Zhuoming Liu

et al.

Nature, Journal Year: 2021, Volume and Issue: 597(7874), P. 97 - 102

Published: July 14, 2021

An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape

Language: Английский

Citations

502