Impact of the Delta variant on vaccine efficacy and response strategies

Expert Review of Vaccines, Journal Year: 2021, Volume and Issue: 20(10), P. 1201 - 1209

Published: Sept. 7, 2021

The Delta variant of SARS-CoV-2 has caused a new wave the COVID-19 epidemic in many countries. It is most infectious to date, and its high infectivity means that higher proportion population needs be vaccinated reduce disease burden, which poses substantial public health challenge.The evolution reviewed, including an overview Plus with K417N mutation RBD, may confer improved immune evasion ability. Decreases serum neutralizing antibody titers after vaccination against were greater than those Alpha but less Beta. protective efficacy existing vaccines have declined related number doses time since vaccination.The currently used are effective hospitalization/severe due variant. Accelerating popularization vaccination, improving coverage rate, implementation intervention measures, such as wearing masks, control spread other variants. However, alone without measures lead continuous emergence

Language: Английский

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Monoclonal antibody therapies against SARS-CoV-2

The Lancet Infectious Diseases, Journal Year: 2022, Volume and Issue: 22(11), P. e311 - e326

Published: July 5, 2022

Language: Английский

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Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection

Journal of Biomedical Science, Journal Year: 2022, Volume and Issue: 29(1)

Published: Jan. 4, 2022

The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public health crisis that demands the timely creation of new therapeutics and viral detection. Owing to their high specificity reliability, monoclonal antibodies (mAbs) have emerged as powerful tools treat detect numerous diseases. Hence, many researchers begun urgently develop Ab-based kits for detection severe acute respiratory syndrome 2 (SARS-CoV-2) Ab drugs use COVID-19 therapeutic agents. detailed structure SARS-CoV-2 spike protein known, since this key infection, its receptor-binding domain (RBD) has become a major target development. Because RNA virus with mutation rate, especially under selective pressure aggressively deployed prophylactic vaccines neutralizing Abs, cocktails expected be important strategy effective treatment. Moreover, infection may stimulate overactive immune response, resulting in cytokine storm drives progression. Abs combat storms also been intense development treatments COVID-19. In addition drugs, are currently being utilized tests, including antigen immunoglobulin tests. Such tests crucial surveillance can used prevent spread Herein, we highlight some points regarding mAb-based pandemic.

Language: Английский

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Acquisition of the L452R Mutation in the ACE2-Binding Interface of Spike Protein Triggers Recent Massive Expansion of SARS-CoV-2 Variants

Journal of Clinical Microbiology, Journal Year: 2021, Volume and Issue: 59(11)

Published: Aug. 11, 2021

We report that there is a recent global expansion of numerous independent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with mutation L452R in the receptor-binding domain (RBD) spike protein. The massive emergence was first linked to lineage B.1.427/B.1.429 (clade 21C) has been spreading California since November and December 2020, originally named CAL.20C currently variant interest epsilon.

Language: Английский

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Structural diversity of the SARS-CoV-2 Omicron spike

Molecular Cell, Journal Year: 2022, Volume and Issue: 82(11), P. 2050 - 2068.e6

Published: March 25, 2022

Language: Английский

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