Blood protein assessment of leading incident diseases and mortality in the UK Biobank DOI Creative Commons
Danni A. Gadd, Robert F. Hillary, Zhana Kuncheva

et al.

Nature Aging, Journal Year: 2024, Volume and Issue: 4(7), P. 939 - 948

Published: July 10, 2024

Abstract The circulating proteome offers insights into the biological pathways that underlie disease. Here, we test relationships between 1,468 Olink protein levels and incidence of 23 age-related diseases mortality in UK Biobank ( n = 47,600). We report 3,209 associations 963 21 incident outcomes. Next, protein-based scores (ProteinScores) are developed using penalized Cox regression. When applied to sets, six ProteinScores improve area under curve estimates for 10-year onset outcomes beyond age, sex a comprehensive set 24 lifestyle factors, clinically relevant biomarkers physical measures. Furthermore, ProteinScore type 2 diabetes outperforms polygenic risk score HbA1c—a clinical marker used monitor diagnose diabetes. performance metabolomic proteomic features is also compared. These data characterize early contributions major diseases, demonstrating value plasma stratification.

Language: Английский

Biological and functional multimorbidity—from mechanisms to management DOI
Claudia Langenberg, Aroon D. Hingorani, C. W. M. Whitty

et al.

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(7), P. 1649 - 1657

Published: July 1, 2023

Language: Английский

Citations

51
Genetic effects on the timing of parturition and links to fetal birth weight DOI Creative Commons
Pol Solé-Navais, Christopher Flatley, Valgerður Steinthórsdóttir

et al.

Nature Genetics, Journal Year: 2023, Volume and Issue: 55(4), P. 559 - 567

Published: April 1, 2023

The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis gestational duration (n = 195,555), identifying 22 associated loci (24 independent variants) an enrichment in genes differentially expressed during labor. A preterm delivery (18,797 cases, 260,246 controls) revealed six large similarities with duration. Analysis the parental transmitted nontransmitted alleles 136,833) shows that 15 variants act through genome, whereas 7 both fetal genomes 2 only via genome. Finally, effects on show signs antagonistic pleiotropy birth weight: increase have negative weight. study provides insights into complex maternal-fetal relationship between

Language: Английский

Citations

48
Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases DOI Creative Commons
Shuai Yuan, Lijuan Wang, Han Zhang

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 89, P. 104488 - 104488

Published: Feb. 24, 2023

Language: Английский

Citations

45
Proteome-Wide Mendelian Randomization Identifies Causal Links Between Blood Proteins and Acute Pancreatitis DOI Open Access
Jérôme Bourgault, Erik Abner, Hasanga D. Manikpurage

et al.

Gastroenterology, Journal Year: 2023, Volume and Issue: 164(6), P. 953 - 965.e3

Published: Feb. 1, 2023

Language: Английский

Citations

43
Blood protein assessment of leading incident diseases and mortality in the UK Biobank DOI Creative Commons
Danni A. Gadd, Robert F. Hillary, Zhana Kuncheva

et al.

Nature Aging, Journal Year: 2024, Volume and Issue: 4(7), P. 939 - 948

Published: July 10, 2024

Abstract The circulating proteome offers insights into the biological pathways that underlie disease. Here, we test relationships between 1,468 Olink protein levels and incidence of 23 age-related diseases mortality in UK Biobank ( n = 47,600). We report 3,209 associations 963 21 incident outcomes. Next, protein-based scores (ProteinScores) are developed using penalized Cox regression. When applied to sets, six ProteinScores improve area under curve estimates for 10-year onset outcomes beyond age, sex a comprehensive set 24 lifestyle factors, clinically relevant biomarkers physical measures. Furthermore, ProteinScore type 2 diabetes outperforms polygenic risk score HbA1c—a clinical marker used monitor diagnose diabetes. performance metabolomic proteomic features is also compared. These data characterize early contributions major diseases, demonstrating value plasma stratification.

Language: Английский

Citations

34