Less, but more: new insights from appendicularians on chordate Fgf evolution and the divergence of tunicate lifestyles. DOI Creative Commons
Gaspar Sánchez-Serna, Jordi Badia‐Ramentol, Paula Bujosa

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Abstract The impact of gene loss on the divergence taxa and generation evolutionary innovations is a fundamental aspect Evolutionary Biology that remains unclear. Here, using evolution Fibroblast Growth Factors (FGFs) in appendicularians as case study, we investigate how losses have influenced chordates, especially among tunicates. Our work reveals an unprecedented massive all Fgf subfamilies, except for Fgf9/16/20 Fgf11/12/13/14 , which turn suffered two bursts duplications. Phylogenetic inferences genomic analyses synteny conservation, architecture, alternative splicing protein 3D-structure allowed us to reconstruct history appendicularian genes context chordate evolution, providing compelling evidence supporting paracrine secreting functions intracellular respectively. Exhaustive analysis developmental expression Oikopleura dioica model paradigmatic what could be referred “less, but more”, conceptual framework characterized by four associated patterns: conservation ancestral domains; function shuffling between paralogs upon loss; innovation new domains after duplications; extinction linked losses. findings this allow formulate novel hypotheses about potential duplications transition from ascidian-like biphasic lifestyle fully free-living style appendicularians. These include co-option patterning oikoblast responsible house development tail fin; recruitment into mouth, their role modulating neuronal excitability; “anterior tail” FGF signaling mesodermal source retinoic acid signaling; link Fgf7/10/22 Fgf8/17/18 drastic metamorphosis, mesenchymal cells lack absorption appendicularians, contrast ascidians.

Language: Английский

Genome assembly of the southern pine beetle ( Dendroctonus frontalis Zimmerman) reveals the origins of gene content reduction in Dendroctonus DOI Creative Commons

Megan Copeland,

Shelby Landa,

Adekola Owoyemi

et al.

Royal Society Open Science, Journal Year: 2024, Volume and Issue: 11(12)

Published: Dec. 1, 2024

also known as southern pine beetle (SPB), is the most damaging insect forest pest in southeastern United States. Genomic data are important to provide information on biology and identify molecular targets develop improved management approaches. Here, we produced a chromosome-level genome assembly of SPB using long-read sequencing data. Synteny analyses confirmed conservation core Coleopteran Stevens elements validated

Language: Английский

Citations

0
Evolution of ion channels in cetaceans: A natural experiment in the Tree of life DOI Creative Commons

C.S. Uribe Uribe,

Mariana F. Nery, Kattina Zavala

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 15, 2023

Abstract Cetaceans could be seen as a natural experiment within the tree of life in which mammalian lineage changed from terrestrial to aquatic habitats. This shift involved extensive phenotypic modifications, represent an opportunity explore genetic bases diversity. Furthermore, availability whole genome sequences representative species all main cetacean groups means that we are golden age for such studies. Among different molecular systems maintain cellular homeostasis, ion channels crucial proper physiological functioning living species. study aims evolution during evolutionary history cetaceans. To do so, created bioinformatic pipeline annotate repertoire included our sampling. Our results show cetaceans have on average, fewer protein-coding genes and higher percentage annotated than non-cetacean mammals. Signals positive selection were detected related heart, locomotion, visual neurological phenotypes. Interestingly, predict Na V 1.5 channel most toothed whales (odontocetes) is sensitive tetrodotoxin (TTX), similar 1.7, given presence tyrosine instead cysteine, specific position channel. Finally, gene turnover rate crown group more three times faster

Language: Английский

Citations

1
Evolution of ion channels in cetaceans: a natural experiment in the tree of life DOI Creative Commons

C.S. Uribe Uribe,

Mariana F. Nery, Kattina Zavala

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 23, 2024

Abstract Cetaceans represent a natural experiment within the tree of life in which lineage changed from terrestrial to aquatic habitats. This shift involved phenotypic modifications, representing an opportunity explore genetic bases diversity. Among different molecular systems that maintain cellular homeostasis, ion channels are crucial for proper physiological functioning all living species. study aims evolution during evolutionary history cetaceans. To do so, we created bioinformatic pipeline annotate repertoire genome species included our sampling. Our main results show cetaceans have, on average, fewer protein-coding genes and higher percentage annotated than non-cetacean mammals. Signals positive selection were detected related heart, locomotion, visual neurological phenotypes. Interestingly, predict NaV1.5 channel most toothed whales (odontocetes) is sensitive tetrodotoxin, similar NaV1.7, given presence tyrosine instead cysteine, specific position channel. Finally, gene turnover rate cetacean crown group more three times faster

Language: Английский

Citations

0
Less, but more: new insights from appendicularians on chordate Fgf evolution and the divergence of tunicate lifestyles. DOI Creative Commons
Gaspar Sánchez-Serna, Jordi Badia‐Ramentol, Paula Bujosa

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Abstract The impact of gene loss on the divergence taxa and generation evolutionary innovations is a fundamental aspect Evolutionary Biology that remains unclear. Here, using evolution Fibroblast Growth Factors (FGFs) in appendicularians as case study, we investigate how losses have influenced chordates, especially among tunicates. Our work reveals an unprecedented massive all Fgf subfamilies, except for Fgf9/16/20 Fgf11/12/13/14 , which turn suffered two bursts duplications. Phylogenetic inferences genomic analyses synteny conservation, architecture, alternative splicing protein 3D-structure allowed us to reconstruct history appendicularian genes context chordate evolution, providing compelling evidence supporting paracrine secreting functions intracellular respectively. Exhaustive analysis developmental expression Oikopleura dioica model paradigmatic what could be referred “less, but more”, conceptual framework characterized by four associated patterns: conservation ancestral domains; function shuffling between paralogs upon loss; innovation new domains after duplications; extinction linked losses. findings this allow formulate novel hypotheses about potential duplications transition from ascidian-like biphasic lifestyle fully free-living style appendicularians. These include co-option patterning oikoblast responsible house development tail fin; recruitment into mouth, their role modulating neuronal excitability; “anterior tail” FGF signaling mesodermal source retinoic acid signaling; link Fgf7/10/22 Fgf8/17/18 drastic metamorphosis, mesenchymal cells lack absorption appendicularians, contrast ascidians.

Language: Английский

Citations

0