Developmental changes in brain-wide fear memory networks DOI Creative Commons
Benita Jin, Michael W. Gongwer, Laura A. DeNardo

et al.

Neurobiology of Learning and Memory, Journal Year: 2025, Volume and Issue: unknown, P. 108037 - 108037

Published: March 1, 2025

Memory retrieval involves coordinated activity across multiple brain regions. Yet how the organization of memory networks evolves throughout development remains poorly understood. In this study, we compared whole-brain functional that are active during contextual fear recall in infant, juvenile, and adult mice. Our analyses revealed long-term change significantly postnatal development. Infant dense heterogeneous, whereas sparse have a small-world topology. While hippocampal subregions were highly connected nodes at all ages, cortex gained many connections Different matured different rates, but their developmental timing fell into three major categories: stepwise between two linear or inverted-U, with elevated connectivity juveniles. work highlights subset regions likely maintain important roles encoding, undergoes significant reorganization Together, these results provide blueprint for studying correlated cellular key areas distinctly regulates storage

Language: Английский

Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory DOI Creative Commons
Wenfei Sun, Zhihui Liu, Xian Jiang

et al.

Nature, Journal Year: 2024, Volume and Issue: 627(8003), P. 374 - 381

Published: Feb. 7, 2024

Abstract Memory encodes past experiences, thereby enabling future plans. The basolateral amygdala is a centre of salience networks that underlie emotional experiences and thus has key role in long-term fear memory formation 1 . Here we used spatial single-cell transcriptomics to illuminate the cellular molecular architecture memory. We identified transcriptional signatures subpopulations neurons astrocytes were memory-specific persisted for weeks. These implicate neuropeptide BDNF signalling, MAPK CREB activation, ubiquitination pathways, synaptic connectivity as components Notably, upon formation, neuronal subpopulation defined by increased Penk decreased Tac expression constituted most prominent component engram amygdala. changes observed both with RNA sequencing single-molecule intact slices, providing rich map engram. data enabled us determine this interacts adjacent astrocytes, functional experiments show require interactions encode

Language: Английский

Citations

58
Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer’s disease DOI Creative Commons
Sara Hijazi, August B. Smit, Ronald E. van Kesteren

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(12), P. 4954 - 4967

Published: July 7, 2023

Abstract Fast-spiking parvalbumin (PV) interneurons are inhibitory with unique morphological and functional properties that allow them to precisely control local circuitry, brain networks memory processing. Since the discovery in 1987 PV is expressed a subset of fast-spiking GABAergic neurons, our knowledge complex molecular physiological these cells has been expanding. In this review, we highlight specific neurons fire at high frequency reliability, enabling network oscillations shape encoding, consolidation retrieval memories. We next discuss multiple studies reporting neuron impairment as critical step neuronal dysfunction cognitive decline mouse models Alzheimer’s disease (AD). Finally, propose potential mechanisms underlying AD argue early changes activity could be causal AD-associated significant contributor pathogenesis.

Language: Английский

Citations

47
Memory circuits in dementia: The engram, hippocampal neurogenesis and Alzheimer’s disease DOI Creative Commons
Orly Lazarov, Muskan Gupta, Pavan Kumar

et al.

Progress in Neurobiology, Journal Year: 2024, Volume and Issue: 236, P. 102601 - 102601

Published: April 1, 2024

Here, we provide an in-depth consideration of our current understanding engrams, spanning from molecular to network levels, and hippocampal neurogenesis, in health Alzheimer's disease (AD). This review highlights novel findings these emerging research fields future directions for therapeutic avenues memory failure dementia. Engrams, AD, neurogenesis have each been extensively studied. The integration topics, however, has relatively less deliberated, is the focus this review. We primarily on dentate gyrus (DG) hippocampus, which a key area episodic formation. Episodic significantly impaired also site adult neurogenesis. Advancements technology, especially opto- chemogenetics, made sophisticated manipulations engram cells possible. Furthermore, innovative methods emerged monitoring neurons, even specific neuronal populations, vivo while animals engage tasks, such as calcium imaging. In imaging contributes more comprehensive cells. Critically, studies DG using technologies shown important contribution both AD. Together, discussion topics provides holistic perspective that motivates questions research.

Language: Английский

Citations

12
Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice DOI
Sylvie L. Lesuis,

Sungmo Park,

Aijm Van Der Hoorn

et al.

Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

12
Episodic memory development: Bridging animal and human research DOI Creative Commons
Juraj Bevandić, Loïc J. Chareyron, Jocelyne Bachevalier

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(7), P. 1060 - 1080

Published: Feb. 14, 2024

Human episodic memory is not functionally evident until about 2 years of age and continues to develop into the school years. Behavioral studies have elucidated this developmental timeline its constituent processes. In tandem, lesion neurophysiological in non-human primates rodents identified key neural substrates circuit mechanisms that may underlie development. Despite progress, collaborative efforts between psychologists neuroscientists remain limited, hindering progress. Here, we seek bridge human development research by offering a comparative review using humans, primates, rodents. We highlight critical theoretical methodological issues limit cross-fertilization propose common framework, adaptable different species, facilitate cross-species endeavors.

Language: Английский

Citations

11
Gamma oscillation plasticity is mediated via parvalbumin interneurons DOI Creative Commons
Michael D. Hadler, Alexandra Tzilivaki, Dietmar Schmitz

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(5)

Published: Jan. 31, 2024

Understanding the plasticity of neuronal networks is an emerging field (patho-) physiological research, yet underlying cellular mechanisms remain poorly understood. Gamma oscillations (30 to 80 hertz), a biomarker cognitive performance, require and potentiate glutamatergic transmission onto parvalbumin-positive interneurons (PVIs), suggesting interface for cell-to-network plasticity. In ex vivo local potential recordings, we demonstrate long-term potentiation hippocampal gamma power. obeys established rules PVI plasticity, requiring calcium-permeable AMPA receptors (CP-AMPARs) metabotropic glutamate (mGluRs). A microcircuit computational model CA3 predicts CP-AMPAR PVIs critically outperforms pyramidal cell in increasing power completely accounts potentiation. We reaffirm this three PVI-targeting animal models, demonstrating that requires PVI-specific signaling via Gq/PKC pathway comprising mGluR5 Gi-sensitive, PKA-dependent pathway. activity-dependent, metabotropically mediated on may serve as guiding principle understanding network health disease.

Language: Английский

Citations

9
Brain-wide immunolabeling and tissue clearing applications for engram research DOI
Alessandra Franceschini, Michelle Jin, Claire W. Chen

et al.

Neurobiology of Learning and Memory, Journal Year: 2025, Volume and Issue: unknown, P. 108032 - 108032

Published: Feb. 1, 2025

Language: Английский

Citations

1
Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation DOI Creative Commons
Anthony D. Ramnauth, Madhavi Tippani, Heena R. Divecha

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(2), P. 115300 - 115300

Published: Feb. 1, 2025

The dentate gyrus of the hippocampus is important for many cognitive functions, including learning, memory, and mood. Here, we present transcriptome-wide spatial gene expression maps human investigate age-associated changes across lifespan. Genes associated with neurogenesis extracellular matrix are enriched in infants decline throughout development maturation. Following infancy, inhibitory neuron markers increase, cellular proliferation decrease. We also identify spatio-molecular signatures that support existing evidence protracted maturation granule cells during adulthood increases neuroinflammation-related expression. Our findings notion hippocampal neurogenic niche undergoes major following infancy molecular regulators brain aging glial- neuropil-enriched tissue.

Language: Английский

Citations

1
The generative grammar of the brain: a critique of internally generated representations DOI
George Drăgoi

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 25(1), P. 60 - 75

Published: Nov. 30, 2023

Language: Английский

Citations

18
KIBRA anchoring the action of PKMζ maintains the persistence of memory DOI Creative Commons
Panayiotis Tsokas, Changchi Hsieh, Rafael E. Flores‐Obando

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(26)

Published: June 26, 2024

How can short-lived molecules selectively maintain the potentiation of activated synapses to sustain long-term memory? Here, we find kidney and brain expressed adaptor protein (KIBRA), a postsynaptic scaffolding genetically linked human memory performance, complexes with kinase Mzeta (PKMζ), anchoring kinase’s potentiating action late-phase (late-LTP) at synapses. Two structurally distinct antagonists KIBRA-PKMζ dimerization disrupt established late-LTP spatial memory, yet neither measurably affects basal synaptic transmission. Neither antagonist PKMζ-independent LTP or that are maintained by compensating PKCs in ζ-knockout mice; thus, both agents require PKMζ for their effect. 1-month-old despite turnover. Therefore, it is not alone, nor KIBRA but continual interaction between two maintains memory.

Language: Английский

Citations

8