Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(19), P. 2329 - 2334
Published: May 22, 2024
Comprehensive
Summary
A
visible
light
photocatalytic
[3+2]
cycloaddition
of
alkynes
with
readily
accessible
organic
iodides
as
the
C3
synthon
is
developed
herein.
By
merging
halogen
atom
transfer
(XAT)
and
hydrogen
(HAT),
alkyl/aryl
serve
a
formal
diradical
precursor
add
across
C‐C
triple
bonds
to
deliver
number
functionalized
cyclopentanes
in
moderate
high
yields
exceptional
regio‐
diastereoselectivity.
reductive
radical‐polar
crossover
mechanism,
involving
cascade
XAT,
radical
addition,
1,5‐HAT,
polar
effect‐promoted
5‐endo
annulation,
single
electron
(SET)
reduction,
protonation,
may
account
for
this
unprecedented
dehalogenative
cycloaddition.
This
work
not
only
expands
repertoire
traditional
RATC
methodology,
but
also
provides
robust
platform
expedient
assembly
cyclopentanes,
valuable
structural
motif
realms
medicinal
chemistry
material
sciences.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(9), P. 4349 - 4373
Published: Jan. 1, 2024
Contact-electro-catalysis
(CEC)
is
an
emerging
field
that
utilizes
electron
transfer
occurring
at
the
liquid–solid
and
even
liquid–liquid
interfaces
because
of
contact-electrification
effect
to
stimulate
redox
reactions.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(11), P. 7791 - 7802
Published: March 10, 2024
The
development
of
new
synthetic
methods
for
B–H
bond
activation
has
been
an
important
research
area
in
boron
cluster
chemistry,
which
may
provide
opportunities
to
broaden
the
application
scope
clusters.
Herein,
we
present
a
reaction
strategy
direct
site-selective
functionalization
nido-carboranes
initiated
by
photoinduced
cage
via
noncovalent
cage···π
interaction.
As
result,
nido-carborane
radical
is
generated
through
single
electron
transfer
from
3D
2D
photocatalyst
upon
irradiation
with
green
light.
resulting
transient
could
be
directly
probed
advanced
time-resolved
EPR
technique.
In
air,
subsequent
transformations
active
have
led
efficient
and
selective
B–N,
B–S,
B–Se
couplings
presence
N-heterocycles,
imines,
thioethers,
thioamides,
selenium
ethers.
This
protocol
also
facilitates
both
late-stage
modification
drugs
synthesis
nido-carborane-based
drug
candidates
neutron
capture
therapy
(BNCT).
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(32), P. 4275 - 4289
Published: Jan. 1, 2024
This
review
describes
the
recent
research
on
radical
hydroboration,
which
covers
different
boron
sources
including
N-heterocyclic
carbene
borane,
bis(pinacolato)diboron
and
pinacolborane,
as
well
strategies
in
boryl
generation.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(9), P. 3060 - 3070
Published: Jan. 1, 2024
Boryls
and
their
compounds
are
important
due
to
diverse
range
of
applications
in
the
fields
materials
science
catalysis.
They
an
integral
part
boron
chemistry,
which
has
attracted
tremendous
research
interest
over
past
few
decades.
In
this
perspective,
we
provide
in-depth
analysis
reaction
chemistry
boryl
from
a
structure
bonding
perspective.
We
discuss
reactivity
boryls
various
transition
metal
complexes
diborane(4)
towards
different
substrate
molecules,
with
focus
on
nucleophilic
electrophilic
properties
processes.
Additionally,
briefly
radicals.
Our
sheds
new
light
unique
potential
for
catalytic
applications.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(44)
Published: July 13, 2024
Allylic
amines
are
prevalent
and
vital
structural
components
present
in
many
bioactive
compounds
natural
products.
Additionally,
they
serve
as
valuable
intermediates
building
blocks,
with
wide-ranging
applications
organic
synthesis.
However,
direct
α-C(sp
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 11, 2025
Boron
compounds
are
widely
employed
in
organic
chemistry,
pharmaceuticals,
and
materials
science.
Among
them,
borylated
heterocycles
serve
as
versatile
synthons
for
the
construction
of
new
C-C
or
C-heteroatom
bonds
via
coupling
radical
processes.
Such
methods
direct
C-H
borylation
reactions
high
synthetic
value
to
reduce
number
steps
amount
waste
improve
efficiency.
Despite
significant
advances,
remains
an
ongoing
challenge
with
great
potential
applications
chemical
synthesis.
Herein,
we
describe
a
photocatalytic
reaction
five-membered
ring
by
employing
stable
N-heterocyclic
carbene
borane
borylating
reagent
photoredox
catalyst.
Under
green
mild
conditions,
was
achieved
on
series
benzo-fused
heterocyclic
compounds.
Further
studies
demonstrate
utility
this
approach
pharmaceutical
agrochemical
research.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 13, 2024
The
innovation
of
synthetic
strategies
for
selective
B-H
functionalization
is
a
pivotal
objective
in
the
realm
boron
cluster
chemistry.
However,
precise,
efficient,
and
rapid
bond
carboranes
that
distant
from
existing
functional
groups
remains
intractable
owing
to
limited
approaches
site-selective
control
established
methods.
Herein,
we
report
dative
bonding
activation
strategy
nonclassical
remote
site
ACS Catalysis,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1294 - 1304
Published: Jan. 7, 2025
Given
the
widespread
presence
of
spirocyclic
scaffolds
in
natural
products
and
pharmacologically
relevant
synthetic
compounds,
development
efficient
methodologies
for
their
construction
holds
great
importance
medicinal
chemistry
pharmaceutical
research.
In
this
study,
a
general
photochemical
dearomative
spirocyclization
nonactivated
arenes
has
been
established.
The
key
to
method
lies
ability
amine-borane
radicals
activate
aryl
bromides
iodides
via
halogen-atom
transfer,
thereby
allowing
conversion
halides
into
corresponding
subsequent
chemodivergent
transformations.
remarkable
compatibility
versatility
1,4-difunctionalization
is
showed
by
rapid
assembly
structurally
diverse
1,4-cyclohexadiene-based
spirocycles
incorporating
oxindole,
indoline,
or
dihydrobenzofuran
subunits.
Moreover,
potential
utility
protocol
exemplified
formal
total
synthesis
vasopressin
V2
receptor
antagonist
Satavaptan.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
11(4), P. 1232 - 1250
Published: Dec. 28, 2023
Recent
advances
in
HAT-induced
C(sp
3
)–H
functionalizations
triggered
by
radical
addition
to
alkynes,
including
5-
exo-trig
,
endo-trig
4-
and
6-
cyclization
cascades,
intermolecular
functionalizations,
are
summarized.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 4, 2024
Abstract
How
substituents
affect
the
conductance
of
single‐molecule
junctions
has
been
a
subject
ongoing
debate.
Here,
comparative
study
on
transport
properties
across
broader
range
experimentally
proposed
and
representative
π‐conjugated
molecular
systems,
each
characterized
by
prototypical
backbone
motifs
with
distinct
terminal
groups
featuring
is
conducted.
Employing
non‐equilibrium
Green's
function
method
within
density
functional
theory,
this
investigation
reveals
significant
impact
junction
due
to
asymmetric
characteristics
arising
from
both
electronic
spatial
effects
induced
di‐substituents
phenanthrene
analogs
C═C
or
B─N
motifs.
Remarkably,
linear
correlation
uncovered,
either
negative
positive,
between
dipole
moment
molecules
conductance,
contingent
upon
whether
governed
highest
occupied
orbital
(HOMO)
lowest
unoccupied
(LUMO)
states.
Furthermore,
validity
descriptor
substantiated
various
substituted
series,
including
2,7‐dipyridylfluorene,
oligo(phenylene
ethynylene),
1,4‐diaminobenzene.
These
findings
underscore
pivotal
role
individual
moment,
easily
determinable,
in
offering
precise
predictive
insight
into
intricate
junctions.
