bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 24, 2025
Abstract
Epilepsy
is
one
of
the
most
common
comorbidities
in
individuals
with
autism
spectrum
disorders
(ASDs).
Many
patients
epilepsy
as
well
ASD
experience
disruptions
their
sleep-wake
cycle
and
exhibit
daily
rhythms
expression
symptoms.
Chronic
exposure
to
light
at
nighttime
can
disrupt
sleep
circadian
rhythms.
Contactin
associated
protein-like
2
knockout
(
Cntnap2
KO)
mice,
a
model
for
disorder
(ASD)
epilepsy,
disturbances
seizure-like
events.
This
study
examines
how
chronic
dim
night
(DLaN)
affects
architecture,
EEG
power
spectra,
seizure
activity
KO
wildtype
(WT)
mice.
Using
electroencephalography
(EEG)
recordings,
male
female
WT
mice
were
exposed
DLaN
(5
lux)
or
6
weeks.
recordings
analyzed
assess
spectrum,
delays
wake
onset
disrupts
patterns
sex-dependent
manner,
females
being
more
affected.
significantly
increased
slow-wave
(SWA,
0.5–4
Hz)
both
indicating
pressure.
Finally,
we
found
that
dramatically
frequency
events
even
occurrence
rate
Spectral
analysis
revealed
theta
power,
suggesting
involvement
hippocampus.
increases
sex-specific
differences.
These
findings
emphasize
potential
risks
reinforcing
need
manage
improve
quality
reduce
risk.
Philosophical Transactions of the Royal Society B Biological Sciences,
Journal Year:
2023,
Volume and Issue:
378(1892)
Published: Oct. 29, 2023
Light
pollution
caused
by
artificial
light
at
night
(ALAN)
is
increasingly
recognized
as
a
major
driver
of
global
environmental
change.
Since
emissions
are
rapidly
growing
in
an
urbanizing
world
and
half
the
human
population
lives
close
to
freshwater
shoreline,
rivers
lakes
ever
more
exposed
worldwide.
However,
although
conditions
critical
aquatic
species,
freshwaters
biodiversity
hotspots
vital
well-being,
only
small
fraction
studies
conducted
on
ALAN
focus
these
ecosystems.
The
effects
broad
concern
all
levels
biodiversity.
Experiments
have
demonstrated
diverse
behavioural
physiological
responses
even
low
levels.
Prominent
examples
skyglow
diel
vertical
migration
zooplankton
suppression
melatonin
production
fish.
vary
widely
among
taxa,
suggesting
consequences
for
species
distribution
patterns,
potential
create
novel
communities
across
ecosystem
boundaries,
cascading
functioning.
Understanding,
predicting
alleviating
ecological
impacts
requires
solid
consideration
physical
properties
propagating
water
multitude
biological
responses.
This
knowledge
urgently
needed
develop
innovative
lighting
concepts,
mitigation
strategies
specifically
targeted
measures.
article
part
theme
issue
‘Light
complex
systems’.
Trends in Endocrinology and Metabolism,
Journal Year:
2024,
Volume and Issue:
35(7), P. 607 - 623
Published: March 8, 2024
Cardiovascular
disease
(CVD)
is
a
global
health
concern.
Circadian
medicine
improves
cardiovascular
care
by
aligning
treatments
with
our
body's
daily
rhythms
and
their
underlying
cellular
circadian
mechanisms.
Time-based
therapies,
or
chronotherapies,
show
special
promise
in
clinical
cardiology.
They
optimize
treatment
schedules
for
better
outcomes
fewer
side
effects
recognizing
the
profound
influence
of
rhythmic
body
cycles.
In
this
review,
we
focus
on
three
chronotherapy
areas
(medication,
light,
meal
timing)
potential
to
enhance
care.
We
also
highlight
pioneering
research
new
field
rest,
gut
microbiome,
novel
chronotherapies
hypertension,
pain
management,
small
molecules
that
targeting
mechanism.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(3), P. 362 - 362
Published: March 18, 2024
Visible
light
refers
to
the
frequencies
within
electromagnetic
spectrum
that
humans
can
see,
encompassing
radiation
with
wavelengths
falling
between
380
nm
760
nm.
The
energy
of
a
single
photon
increases
its
frequency.
In
retina,
photoreceptor
cells
contain
light-sensitive
pigments
absorb
and
convert
it
into
electrical
stimuli
through
process
known
as
phototransduction.
However,
since
absorption
photoreceptors
closely
aligns
blue
(ranging
from
400
500
nm),
exposure
high
intensities
or
continuous
illumination
result
in
oxidative
stress
these
cells,
leading
loss
their
functionality.
Apart
retina
also
houses
photosensitive
ganglion
intrinsically
retinal
(ipRGCs).
These
relay
information
suprachiasmatic
nucleus
brain,
playing
crucial
role
modulating
melatonin
secretion,
which
turn
helps
synchronizing
body’s
circadian
rhythms
responses
seasonal
changes.
Both,
ipRGCs
skin
possess
peak
sensitivity
wavelengths,
rendering
them
particularly
susceptible
effects
excessive
exposure.
This
study
delves
consequences
and/or
prolonged
on
function
explores
implications
for
human
health.
Environmental Research,
Journal Year:
2024,
Volume and Issue:
263, P. 119897 - 119897
Published: Aug. 31, 2024
Nighttime
light
is
a
growing
anthropogenic
health
threat,
particularly
in
urban
areas.
Limited
evidence
suggests
that
exposure
to
outdoor
artificial
at
night
(ALAN)
may
be
associated
with
people's
mental
by
disrupting
sleep-wake
cycles.
