International Journal of Environmental Research and Public Health,
Journal Year:
2024,
Volume and Issue:
21(12), P. 1546 - 1546
Published: Nov. 22, 2024
The
gut
microbiota
plays
a
fundamental
role
in
the
host's
energy
metabolism
and
development
of
metabolic
diseases
such
as
arterial
hypertension,
insulin
resistance,
atherosclerosis.
Our
study
aimed
to
investigate
potential
hypertension
among
individuals
Kazakh
population
without
resistance.
16S
rRNA
gene
sequencing
faecal
samples
from
197
subjects
was
performed.
Preliminary
binary
comparisons
composition
depending
on
presence
resistance
revealed
statistically
significant
differences
abundance
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2506 - 2506
Published: March 11, 2025
Staphylococcus
aureus-induced
mastitis
is
a
significant
cause
of
economic
losses
in
the
dairy
industry,
yet
its
molecular
mechanisms
remain
poorly
defined.
Although
ferroptosis,
regulated
cell
death
process,
associated
with
inflammatory
diseases,
role
bovine
unknown.
In
this
study,
11
S.
aureus
strains
were
isolated
from
milk
samples
obtained
cows
clinical
or
subclinical
mastitis.
Transcriptome
analysis
Mac-T
cells
challenged
identified
differentially
expressed
genes
(DEGs).
Enrichment
revealed
associations
between
DEG
clusters
and
traits
related
to
KEGG
pathway
enrichment
Toll-like
receptor,
TNF
signaling
as
significantly
enriched
pathways.
Weighted
gene
co-expression
network
(WGCNA)
further
prioritized
ferroptosis-related
(HMOX1,
SLC11A2,
STEAP3,
SAT1,
VDAC2)
involved
iron
metabolism.
Notably,
expression
levels
HMOX1
SAT1
increased
aureus-challenged
cells,
upregulation
was
consistent
trends
observed
transcriptome
data
mother–daughter
pairs
caused
by
infection.
Furthermore,
Ferrostatin-1
treatment
reduced
confirming
involvement
ferroptosis
process.
This
study
reveals
that
plays
key
highlights
potential
target
for
breeding
strategies
aimed
at
improving
resistance.
Cells,
Journal Year:
2025,
Volume and Issue:
14(7), P. 554 - 554
Published: April 7, 2025
Musculoskeletal
injuries
comprise
a
wide
range
of
physical
conditions
impacting
the
coordination
bones,
muscles,
and
joints.
Estimations
suggest
that
close
to
one-third
world’s
population
will
experience
musculoskeletal
or
non-musculoskeletal
injury
at
some
point
in
their
life.
affect
athletes,
office
workers,
industrial
older
adults,
children
every
year.
Among
individuals
over
age
65,
disproportionately
women,
limiting
ability
maintain
an
active
professional
life
engage
leisure
activities
during
retirement.
The
field
therapy
has
recently
expanded
build
understanding
complex,
non-linear
interactions
between
gut
microbiota
system.
There
is
unexpected
connection
both
pain
healing
process
following
injuries.
Understanding
mechanisms
microbiota’s
influence
on
these
could
inform
healthcare
strategies
aimed
prevention
recovery.
For
patients
who
suffer
from
are
risk
developing
injuries,
analyzing
composition
plays
crucial
role
patient
stratification,
which
can
significantly
enhance
effectiveness
treatment
strategies.
Gut Microbes,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: April 14, 2025
Gut
microbiota
have
been
shown
to
influence
the
social
behaviors
of
their
hosts,
while
variations
in
host
genetics
can
affect
composition
microbiome.
Nonetheless,
degree
which
genetic
microbial
populations
impact
behavior,
as
well
any
potential
transgenerational
effects,
remains
inadequately
understood.
Utilizing
C.
elegans
a
model
organism,
we
identified
77
strains
E.
coli
from
total
3,983
mutants
that
significantly
enhanced
aggregation
behavior
through
various
neurobehavioral
pathways.
This
discovery
underscores
collaborative
regulatory
mechanism
between
and
behavior.
Notably,
observed
some
mutant
bacteria
might
via
mitochondrial
pathway.
Additionally,
modulation
has
heritable
trait
offspring.
Our
results
provide
novel
perspective
on
role
variation
may
significant
implications
for
human
studies
development
genetically
engineered
probiotics
aimed
at
enhancing
well-being
across
generations.
Trends in Ecology & Evolution,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
All
species
host
a
rich
community
of
microbes.
This
microbiome
is
dynamic,
and
displays
seasonal,
daily,
even
hourly
changes,
but
also
needs
to
be
resilient
fulfill
important
roles
for
the
host.
In
evolutionary
ecology,
focus
dynamism
has
been
on
how
it
can
facilitate
adaptation
novel
environments.
However,
an
hitherto
largely
overlooked
issue
that
keep
its
in
check,
which
costly
leads
trade-offs
with
investing
other
fitness-related
traits.
Investigating
these
natural
vertebrate
systems
by
collecting
longitudinal
data
will
lead
deeper
insight
into
mechanisms
shape
host-microbiome
interactions.
Immunological Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 16, 2024
Summary
The
increasing
prevalence
of
immune‐mediated
non‐communicable
chronic
diseases,
such
as
food
allergies,
has
prompted
a
deeper
investigation
into
the
role
gut
microbiome
in
modulating
immune
responses.
Here,
we
explore
complex
interactions
between
commensal
microbes
and
host
system,
highlighting
critical
bacteria
maintaining
homeostasis.
We
examine
how
modern
lifestyle
practices
environmental
factors
have
disrupted
co‐evolved
host–microbe
discuss
changes
composition
impact
epithelial
barrier
function,
responses
to
allergens,
susceptibility
allergic
diseases.
Finally,
potential
bioengineered
microbiome‐based
therapies,
live
biotherapeutic
products,
for
reestablishing
homeostasis
prevent
or
treat
allergies.
