Circadian rhythms in muscle health and diseases DOI
Jeffrey J. Kelu

International review of cell and molecular biology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Circadian clock communication during homeostasis and ageing DOI
Thomas Mortimer, Jacob G. Smith, Pura Muñoz‐Cánoves

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

Citations

3
The Common Hallmarks of Aging, Circadian Rhythms and Cancer: Implications for Therapeutic Strategies DOI Creative Commons
Jie Wang, Fanglin Shao, Qingxin Yu

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.

Language: Английский

Citations

3
Long-term obesity impacts brain morphology, functional connectivity and cognition in adults DOI
Die Zhang, Chenye Shen, Nanguang Chen

et al.

Nature Mental Health, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

Citations

2
Causal association of sarcopenia-related traits with brain cortical structure: a bidirectional Mendelian randomization study DOI Creative Commons

Yuxuan Zhan,

Zhiyun Zhang,

Siyi Lin

et al.

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: Feb. 27, 2025

Abstract Background Patients with sarcopenia often experience cognitive decline, affecting cortical structures, but the causal link remains unclear. We used bidirectional Mendelian randomization (MR) to explore relationship between sarcopenia-related traits and structure. Methods selected genetic variables from genome-wide association study data. Three different MR methods were used: inverse-variance weighted analysis, MR-Egger regression, median test. For significant estimates, we further conducted Cochran’s Q test, intercept leave-one-out analyses, MR-PRESSO assess heterogeneity. Results In forward appendicular lean mass (ALM) decreased thickness (TH) of lateral occipital gyrus increased TH pars opercularis (β = -0.0079 mm, 95% CI: -0.0117 mm -0.0041 P < 0.0001; β 0.0080 0.0042 0.0117 0.0001). reverse a negative correlation was found bankssts ALM, while positive correlations observed frontal pole, rostral anterior cingulate, temporal ALM. The pole positively correlated right hand grip strength (HGS-R) 0.1596 0.1349 0.1843 0.0001), triangularis left-hand (HGS-L) 0.3251 0.2339 0.4163 Conclusions Sarcopenia-related structure have effects, supporting muscle-brain axis theory. This links neurocognitive diseases provides new strategies for prevention intervention both decline.

Language: Английский

Citations

1
Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling DOI

Jianghui Chen,

Jing Xiang, Meiyu Zhou

et al.

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
The circadian clock at the intersection of metabolism and aging – emerging roles of metabolites DOI Creative Commons
Yue Dong, Sin Man Lam, Yan Li

et al.

Journal of genetics and genomics/Journal of Genetics and Genomics, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

1
Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia DOI Creative Commons
Jeffrey J. Kelu, Simon M. Hughes

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(19)

Published: May 5, 2025

How central and peripheral circadian clocks regulate protein metabolism affect tissue mass homeostasis has been unclear. Circadian shifts in the balance between anabolism catabolism control muscle growth rate young zebrafish independent of behavioral cycles. Here, we show that ubiquitin–proteasome system (UPS) autophagy, which mediate degradation, are each upregulated at night under clock. Perturbation transcriptional molecular clock disrupts nocturnal proteolysis, increases measured over 12 h, compromises function. Mechanistically, shifting Ror Rev-erb regulates UPS, through altered TORC1 activity. Although environmental zeitgebers initially mitigate defects, lifelong inhibition reduces size rate, accelerating aging-related loss misalignment such as shift work, sleep deprivation, or dementia may thus unsettle proteostasis, contributing to wasting sarcopenia.

Language: Английский

Citations

1
Lack of Bmal1 leads to changes in rhythmicity and impairs motivation towards natural stimuli DOI Creative Commons
Paula Berbegal-Sáez, Inés Gallego‐Landin, Javier Macía

et al.

Open Biology, Journal Year: 2024, Volume and Issue: 14(7)

Published: July 1, 2024

Maintaining proper circadian rhythms is essential for coordinating biological functions in mammals. This study investigates the effects of daily arrhythmicity using Bmal1-knockout (KO) mice as a model, aiming to understand behavioural and motivational implications. By employing new mathematical analysis based on entropy divergence, we identified disrupted intricate activity patterns derived by complete absence BMAL1 quantified difference regarding oscillation’s complexity. Changes locomotor coincided with disturbances gene expression patterns. Additionally, found dysregulated profile particularly brain nuclei like ventral striatum, impacting genes related reward motivation. Further investigation revealed that arrhythmic exhibited heightened motivation food water rewards, indicating link between disruptions system. research sheds light how clock alterations impact regulating system this, turn, can lead altered seeking behaviour natural rewards. In summary, present contributes our understanding processing under regulation machinery.

Language: Английский

Citations

3
Ablation of satellite cell‐specific clock gene, Bmal1, alters force production, muscle damage, and repair following contractile‐induced injury DOI Creative Commons
Ryan E. Kahn, Pei Zhu, Ishan Roy

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(2)

Published: Jan. 15, 2025

Abstract Following injury, skeletal muscle undergoes repair via satellite cell (SC)‐mediated myogenic progression. In SCs, the circadian molecular clock gene, Bmal1, is necessary for appropriate progression and with evidence that clocks can also affect force production. Utilizing a mouse model allowing inducible depletion of Bmal1 within we determined contractile function, SC damage following eccentric contractile‐induced injury. At baseline, SC‐ iKO animals exhibited ~20–25% reduction in normalized production (ex vivo vivo) versus control Cntrl untreated littermates ( p < .05). displayed reduced subsequent post‐injury (Dystrophin negative fibers 24 h: 199 ± 41; 36 13, .05) (eMHC + 7 day: 217.8 115.5; 27.8 17.3; Centralized nuclei 160.7 70.5; 46.2 15.7). showed neutrophil infiltration, consistent less injury (Neutrophil content 2.4 0.4; 0.4 0.2, % area fraction, had greater activation/proliferation at an earlier timepoint unexplained increase activation days post Collectively, these data suggest plays regulatory role production, influencing magnitude damage/repair, altered

Language: Английский

Citations

0
The central clock drives metabolic rhythms in muscle stem cells DOI Creative Commons
Valentina Sica, Jacob G. Smith, Oleg Deryagin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Summary Circadian rhythms are essential for organismal health. Satellite cells (SCs), the muscle resident stem cells, maintain a state of quiescence yet exhibit robust circadian oscillations at transcriptional level. Although peripheral clocks have been extensively studied in various tissues, how intrinsic clock interacts with central, distal is largely unknown. We used SC-specific reconstitution gene Bmal1 to elucidate role local SC and its interplay central mouse brain found that daily control metabolic processes SCs depend on input, independent clock. Central clock-driven genes were involved lipid metabolism, functionally important SC-mediated repair, autophagy was required their oscillation. In summary, we provide first evidence coordination rhythmic expression quiescent cells. Highlights Brain:satellite cell communication restores core machinery satellite Brain inputs dominant regulator transcript SCs, driving oscillation genes. Autophagy Early phases regeneration brain-driven signals.

Language: Английский

Citations

0