Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(10), P. 667 - 667
Published: Aug. 22, 2024
Language: Английский
Science, Journal Year: 2025, Volume and Issue: 388(6742), P. 96 - 104
Published: April 4, 2025
T cells have emerged as orchestrators of pain amplification, but the mechanism by which control processing is unresolved. We found that regulatory (T reg cells) could inhibit nociception through a was not dependent on their ability to regulate immune activation and tissue repair. Site-specific depletion or expansion meningeal (mT in mice led female-specific sex hormone–dependent modulation mechanical sensitivity. Specifically, mT produced endogenous opioid enkephalin exerted an antinociceptive action delta receptor expressed MrgprD + sensory neurons. Although restrains nociceptive processing, it dispensable for cell–mediated immunosuppression. Thus, our findings uncovered sexually dimorphic immunological circuit nociception, establishing sentinels homeostasis.
Language: Английский
Citations
0
Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Sensing and recognition are key properties of both the immune nervous systems. In system, pattern or antigen-specific receptors represent classic motifs in innate adaptive immunity, respectively. there is a major anatomic division between how we sense stimuli from within body (vagal sensory system) outside world (somatosensory system). However, last 5 years, has been an explosion discoveries revealing interactions systems that govern array physiologic pathologic processes including allergy, infection, autoimmunity, regeneration, cancer, beyond. Herein, highlight recent advances demonstrate peripheral neuroimmunology emerged as powerful field provides new insights into immunologic hypersensitivity, inflammation, tissue homeostasis.
Language: Английский
Citations
0
Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0
Immunological Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 17, 2024
Summary The early development of the neonatal immune system is profoundly influenced by exposure to dietary and microbial antigens, which shapes mucosal tolerance. Successful oral tolerance induction crucially dependent on microbially imprinted cells, most notably RORγt + regulatory T (Treg) antigen presenting cells essential for preventing food allergy (FA). FA can be envisioned result from disruptions at key checkpoints (CKPTs) that govern induction. These include gut epithelial sensory effector circuits when dysregulated promote pro‐allergic dysbiosis. They also are disrupted dysbiosis responses unleashed dysregulation aforementioned cascades. Understanding these developing therapeutic strategies restore homeostasis in FA.
Language: Английский
Citations
3
Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1103 - 1103
Published: Sept. 2, 2024
A defining unique characteristic of the gut immune system is its ability to respond effectively foreign pathogens while mitigating unnecessary inflammation. Intestinal macrophages serve as cornerstone this balancing act, acting uniquely both sword and shield in microenvironment. The GI tract densely innervated by enteric nervous (ENS), intrinsic gut. Recent advances sequencing technology have increasingly suggested neuroimmune crosstalk a critical component for homeostasis within other tissues. Here, we systematically review ENS–macrophage axis. We focus on pertinent molecules produced ENS, spotlight mechanistic contributions intestinal inflammation, discuss existing potential strategies that use integrate signals from ENS. This aims elucidate complex molecular basis governing signaling, highlighting their cooperative roles sustaining health equilibrium.
Language: Английский
Citations
2
Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 22(3), P. 206 - 221
Published: Nov. 22, 2024
Language: Английский
Citations
2
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 2, 2024
Abstract The nervous and immune systems are closely interconnected, influence the onset progress of various diseases. Accordingly, understanding interaction neural system becomes very important for treatment intractable diseases with analysis therapeutic mechanisms, such as autoimmune diseases, neurodegenerative cancers, so on. conventional immunomodulation treatments have been mainly carried out by drug administration, but they suffered from systemic negative side‐effects only limited effects on specific disease. In this Perspective, photonic nanomaterials devices reviewed discussed digitally controlled neurostimulating photomedicine via photobiomodulation optogenetics unique viewpoint neuro‐immune cross‐talks. prospects perspectives to integrate advanced wearable implantable healthcare also provided highlighted revolutionize strategies systems, optimize protocols futuristic digital photomedicine. This approach will fields neurostimulation regulation further clinical applications.
Language: Английский
Citations
2
Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5700 - 5700
Published: Dec. 2, 2024
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's (PD), and Huntington's (HD) have become a major global health burden, but the detailed pathogeneses of neurodegenerative are still unknown, current treatments mainly aimed at controlling symptoms; there no curative for or progressive cognitive, behavioral, functional impairments that they cause. Studies shown some plant extracts with pungent flavor components certain neuroprotective effect in diseases, their mechanisms involve inhibiting neuronal apoptosis, promoting regeneration, reducing mitochondrial degeneration, production oxides reactive oxygen species cells, which great significance exploring treatment diseases. In this review, we searched PubMed database relevant literature collected past 15 years. Finally, summarized protective effects capsaicin, piperine, curcumin, cannabinoids, allicin, nicotine on nervous system, focusing molecular signaling pathways activate. addition, also compiled laboratory experiments, preclinical various The goal is to further explore potential effective drugs provide new ideas research specific these substances targets drug action future.
Language: Английский
Citations
1
Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Nov. 6, 2024
In this hypothesis article, the potential clinicopathological associations of Calcitonin Gene Related Peptide (CGRP) with development synuclein-associated neurodegenerative disorders (SAND) are discussed. The presence α -syn and CGRP in CNS ENS intricate role its related pathways inflammation, apoptosis, metabolism, neuromodulation, brain-gut communication analyzed. Since is confirmed, modulating CGRP-potential may lead to novel disease-modifying therapies.
Language: Английский
Citations
1
Science, Journal Year: 2024, Volume and Issue: 385(6708), P. 496 - 497
Published: Aug. 1, 2024
A chemogenetic screen reveals links between nociceptors and gut immune function
Language: Английский
Citations
0