Spare the pain for your gut Treg cells!

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(10), P. 859 - 861

Published: Sept. 5, 2024

Language: Английский

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Unraveling TRPV1’s Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4729 - 4729

Published: Oct. 7, 2024

Cancer is a global health challenge with rising incidence and mortality rates, posing significant concerns. The World Health Organization reports cancer as leading cause of death worldwide, contributing to nearly one in six deaths. pathogenesis involves disruptions cellular signaling pathways, resulting uncontrolled cell growth metastasis. Among emerging players biology, Transient Receptor Potential (TRP) channels, notably TRPV1, have garnered attention due their altered expression cells roles tumorigenesis progression. also known the capsaicin receptor, pivotal pain mediation, offering promise therapeutic target. Activation TRPV1 triggers calcium influx affects linked death. Additionally, implicated cancer-induced chemo-sensitivity, upregulation observed sensory neurons innervating oral cancers. Also, when capsaicin, compound from chili peppers, interacts it elicits "hot" sensation influences processes through influx. Understanding TRPV1's multifaceted may lead novel strategies for managing cancer-related symptoms improving patient outcomes. current review elucidates comprehensive role therapy, particularly channel, highlighting its effects various via different pathways discussing limitations.

Language: Английский

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Human regulatory γδT lymphocytes as novel autoimmunity-protective cells: Lessons from alopecia areata

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Regulatory T cells control autoimmune diseases (AID). Yet, much less is known about the functions of evolutionarily older Foxp3 + human regulatory γδT (γδTregs). Here, we have explored these in one most common AID, hair loss disorder, alopecia areata (AA). Lesional AA skin showed significantly more γδTreg than non-lesional or healthy skin. Next, investigated how γδTregs impact on experimentally induced scalp xenotransplants SCID/beige mice. PBMC-derived autologous were pre-activated with IL-2, IL-15, and zoledronate in vitro injected intradermally into xenografts before after induction by CD8 vivo. not only prevented development lesions, but also promoted regrowth established lesions xenotransplants, accompanied a reduced perifollicular lymphocytic infiltrate restoration follicle (HF) immune privilege (IP) . We then co-cultured organ-cultured, stressed (MICA-overexpressing) HFs presence/absence pathogenic CD8+/NKG2D that induce HF IP collapse secreting interferon-g, all under conditions. Under ex vivo conditions, mitigated cells, primarily through IL-10 TGF-β1 secretion, enhanced keratinocyte proliferation their apoptosis while preventing premature catagen (= hallmarks). These findings model AID introduce as important lymphocytes invite novel cell-based therapies cell-dependent AIDs characterized such AA.

Language: Английский

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Sensory innervation in the prostate and a role for calcitonin gene-related peptide in prostatic epithelial proliferation

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Dec. 18, 2024

The prostate is densely innervated like many visceral organs and glands. However, studies to date have focused on sympathetic parasympathetic nerves little attention has been given the presence or function of sensory in prostate. Recent highlighted a role for beyond perception noxious stimuli, as anterograde release neuropeptides from can affect vascular tone local immune responses.

Language: Английский

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Mapping neuroimmune interactions in the gut

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(10), P. 667 - 667

Published: Aug. 22, 2024

Language: Английский

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