Norepinephrine signals through astrocytes to modulate synapses DOI
Katheryn B. Lefton, Yifan Wu, Yanchao Dai

et al.

Science, Journal Year: 2025, Volume and Issue: 388(6748), P. 776 - 783

Published: May 15, 2025

Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level mechanisms are elusive. Here, we show that NE remodeling of synaptic function is completely independent from its binding on neuronal receptors. Instead, astrocytic adrenergic receptors calcium dynamics fully gate effect synapses. Additionally, found suppression strength results an adenosine 5′-triphosphate (ATP)–derived A1 receptor–mediated control presynaptic efficacy. These findings suggest astrocytes a core component neuromodulatory systems effector through which produces adaptations.

Language: Английский

Astrocytes, hidden puppet masters of the brain DOI
Çağla Eroğlu

Science, Journal Year: 2025, Volume and Issue: 388(6748), P. 705 - 706

Published: May 15, 2025

Astrocyte signaling pathways influence neuronal networks and behavioral responses to neuromodulators

Language: Английский

Citations

0
Norepinephrine signals through astrocytes to modulate synapses DOI
Katheryn B. Lefton, Yifan Wu, Yanchao Dai

et al.

Science, Journal Year: 2025, Volume and Issue: 388(6748), P. 776 - 783

Published: May 15, 2025

Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level mechanisms are elusive. Here, we show that NE remodeling of synaptic function is completely independent from its binding on neuronal receptors. Instead, astrocytic adrenergic receptors calcium dynamics fully gate effect synapses. Additionally, found suppression strength results an adenosine 5′-triphosphate (ATP)–derived A1 receptor–mediated control presynaptic efficacy. These findings suggest astrocytes a core component neuromodulatory systems effector through which produces adaptations.

Language: Английский

Citations

0