Brain circuits that regulate social behavior DOI Creative Commons
Hao Li, Zhe Zhao,

Shaofei Jiang

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Social interactions are essential for the survival of individuals and reproduction populations. stressors, such as social defeat isolation, can lead to emotional disorders cognitive impairments. Furthermore, dysfunctional behaviors hallmark symptoms various neuropsychiatric disorders, including autism spectrum disorder (ASD) post-traumatic stress (PTSD). Consequently, understanding neural circuit mechanisms underlying has become a major focus in neuroscience. behaviors, which encompass wide range expressions phases, regulated by complex networks. In this review, we summarize recent progress identifying circuits involved different types general investigation, preference, mating, aggression, parenting, prosocial dominance behaviors. We also outline associated with deficits ASD, schizophrenia, PTSD. Given pivotal role rodents behavior research, our review primarily focuses on these animals. Finally, propose future research directions, development specific behavioral paradigms, identification motor output, integration activity, transcriptome, connectome data, multifunctional roles neurons multiple targets, among brain regions.

Language: Английский

Compensatory synaptotagmin-11 expression conceals parkinson’s disease-like phenotypes in parkin knockout mice DOI Creative Commons
Nan Dong,

Zhenli Xie,

Anqi Wei

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 3, 2025

Animal models are crucial for elucidating the pathological mechanisms underlying Parkinson's disease (PD). Unfortunately, most of transgenic mouse fail to manifest changes observed in PD patients, pending advancement research. However, mechanism this discrepancy remains elusive. Here, we provide compelling evidence that compensatory expression synaptotagmin-11 (Syt11) plays a key role concealing PD-associated phenotypes parkin knockout (KO) models. Unlike normal dopamine (DA) release and motor behaviors KO mice, knockdown (KD) substantia nigra pars compacta (SNpc) adult mice led both impaired DA pronounced deficits. Interestingly, Syt11, well-established substrate involved PD, was specifically upregulated KD during suckling stage, but not mice. Importantly, overexpression Syt11 alone is capable inducing PD-like non-motor impairments, as well reuptake, which essential parkin-associated pathogenesis PD. Therefore, work only elucidate accounts absence overt also contribute comprehensive understanding progression opening new avenues therapeutic treatment

Language: Английский

Citations

0
Pathways to sex preferences DOI

Katherine Whalley

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

0
Dopaminergic mechanisms of dynamical social specialization in mouse microsocieties DOI Creative Commons
Clément Prévost-Solié,

Anne Nicolson,

Robert Justo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Summary Social organization and division of labor are fundamental to animal societies, but how do these structures emerge from individual interactions, what role does neuromodulation play in shaping them? Using behavioral tracking a semi-natural environment, neural recordings, computational models integrating reinforcement social learning, we show that groups three isogenic mice spontaneously develop specialized roles while solving foraging task requiring decisions under constraints. Moreover, shaped by dopaminergic activity the ventral tegmental area. Strikingly, despite minor sex-differences behavior when were tested alone, male triads formed stable worker-scrounger relationships driven competition, whereas female adopted uniform, cooperative strategies. Model analysis revealed intra- inter-sex parameter differences resource exploitation, combined with contingent dynamic drive specialization division. Most notably, it highlighted contingency, amplified magnifies shapes profiles. The plastic, adaptive nature within was confirmed manipulating cell activity, which reshaped altered group structure. Our findings support feedback loop where context states, turn reinforce stabilize structures.

Language: Английский

Citations

0
An automated two-choice social operant task for probing moment-to-moment changes in social satiety DOI Creative Commons
Nancy R. Mack, Tomohito Minakuchi,

Ken Igarza

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

ABSTRACT In naturalistic conditions, animals must routinely make ongoing self-motivated choices about whether to initiate interactions with same or opposite-sex partners and re-initiate social contact when have ended. However, it remains unclear what governs these choices, they are motivated by drive states that exhibit signatures of moment-to-moment satiety Here, explicitly test this at the behavioral level, we designed a novel fully-automated two-choice operant paradigm where individuals can choose between rewards delivered for interaction systematically varying durations. We trained cohorts both sexes on task quantified patterns choices. used choice latency as metric infer increased duration leads satiety. find although males females stable biases across sessions, showing consistent opposite sex biases, only sensitive interaction. Using simple normative model capture choice, observe behavior is better fit has single evolving bias, rather than multiple, independent drives interactions. Together, our data reveal offer new insights into underlying homeostatic motivational govern

Language: Английский

Citations

0
Lung inflammation drives Long Covid DOI
Alan Sariol, Stanley Perlman

Science, Journal Year: 2025, Volume and Issue: 387(6738), P. 1039 - 1040

Published: March 6, 2025

Peroxisome dysfunction in macrophages impairs lung repair after COVID-19 mice.

Language: Английский

Citations

0
Environment impacts sexual preference: dopamine sends signals under pressure to decide which sex you like DOI Creative Commons
Rou Li, Lin Liu, Min Wu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: April 17, 2025

Language: Английский

Citations

0
Brain circuits that regulate social behavior DOI Creative Commons
Hao Li, Zhe Zhao,

Shaofei Jiang

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Social interactions are essential for the survival of individuals and reproduction populations. stressors, such as social defeat isolation, can lead to emotional disorders cognitive impairments. Furthermore, dysfunctional behaviors hallmark symptoms various neuropsychiatric disorders, including autism spectrum disorder (ASD) post-traumatic stress (PTSD). Consequently, understanding neural circuit mechanisms underlying has become a major focus in neuroscience. behaviors, which encompass wide range expressions phases, regulated by complex networks. In this review, we summarize recent progress identifying circuits involved different types general investigation, preference, mating, aggression, parenting, prosocial dominance behaviors. We also outline associated with deficits ASD, schizophrenia, PTSD. Given pivotal role rodents behavior research, our review primarily focuses on these animals. Finally, propose future research directions, development specific behavioral paradigms, identification motor output, integration activity, transcriptome, connectome data, multifunctional roles neurons multiple targets, among brain regions.

Language: Английский

Citations

0