Advances and Challenges in Sepsis Management: Modern Tools and Future Directions DOI Creative Commons
Elena Santacroce,

Miriam D’Angerio,

Alin Liviu Ciobanu

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 439 - 439

Published: March 2, 2024

Sepsis, a critical condition marked by systemic inflammation, profoundly impacts both innate and adaptive immunity, often resulting in lymphopenia. This immune alteration can spare regulatory T cells (Tregs) but significantly affects other lymphocyte subsets, leading to diminished effector functions, altered cytokine profiles, metabolic changes. The complexity of sepsis stems not only from its pathophysiology also the heterogeneity patient responses, posing significant challenges developing universally effective therapies. review emphasizes importance phenotyping enhance patient-specific diagnostic therapeutic strategies. Phenotyping cells, which categorizes patients based on clinical immunological characteristics, is pivotal for tailoring treatment approaches. Flow cytometry emerges as crucial tool this endeavor, offering rapid, low cost detailed analysis cell populations their functional states. Indeed, technology facilitates understanding dysfunctions contributes identification novel biomarkers. Our underscores potential integrating flow with omics data, machine learning observations refine management, highlighting shift towards personalized medicine care. approach could lead more precise interventions, improving outcomes heterogeneously affected population.

Language: Английский

Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19 DOI Open Access
Anna H.E. Roukens, Cilia R. Pothast, Marion König

et al.

Nature Immunology, Journal Year: 2021, Volume and Issue: 23(1), P. 23 - 32

Published: Dec. 22, 2021

Language: Английский

Citations

109
The Lactate and the Lactate Dehydrogenase in Inflammatory Diseases and Major Risk Factors in COVID-19 Patients DOI Open Access
G. S. Gupta

Inflammation, Journal Year: 2022, Volume and Issue: 45(6), P. 2091 - 2123

Published: May 19, 2022

Language: Английский

Citations

88
SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells DOI Creative Commons
Nicolas Huot, Cyril Planchais,

Pierre Rosenbaum

et al.

Nature Immunology, Journal Year: 2023, Volume and Issue: 24(12), P. 2068 - 2079

Published: Nov. 2, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA generally becomes undetectable in upper airways after a few days or weeks postinfection. Here we used model of viral infection macaques to address whether SARS-CoV-2 persists the body and which mechanisms regulate its persistence. Replication-competent virus was detected bronchioalveolar lavage (BAL) macrophages beyond 6 months Viral propagation BAL occurred from cell inhibited by interferon-γ (IFN-γ). IFN-γ production strongest NKG2r+CD8+ T cells NKG2Alo natural killer (NK) further increased NK spike protein stimulation. However, impaired with persisting virus. Moreover, also enhanced expression major histocompatibility complex (MHC)-E on macrophages, possibly inhibiting cell-mediated killing. Macaques less mounted adaptive that escaped MHC-E-dependent inhibition. Our findings reveal an interplay between regulated persistence mediated IFN-γ.

Language: Английский

Citations

45
Natural Killer Cells and Cytotoxic T Cells: Complementary Partners against Microorganisms and Cancer DOI Creative Commons
Aristo Vojdani, Sadi Köksoy, Elroy Vojdani

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(1), P. 230 - 230

Published: Jan. 22, 2024

Natural killer (NK) cells and cytotoxic T (CD8

Language: Английский

Citations

26
Advances and Challenges in Sepsis Management: Modern Tools and Future Directions DOI Creative Commons
Elena Santacroce,

Miriam D’Angerio,

Alin Liviu Ciobanu

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 439 - 439

Published: March 2, 2024

Sepsis, a critical condition marked by systemic inflammation, profoundly impacts both innate and adaptive immunity, often resulting in lymphopenia. This immune alteration can spare regulatory T cells (Tregs) but significantly affects other lymphocyte subsets, leading to diminished effector functions, altered cytokine profiles, metabolic changes. The complexity of sepsis stems not only from its pathophysiology also the heterogeneity patient responses, posing significant challenges developing universally effective therapies. review emphasizes importance phenotyping enhance patient-specific diagnostic therapeutic strategies. Phenotyping cells, which categorizes patients based on clinical immunological characteristics, is pivotal for tailoring treatment approaches. Flow cytometry emerges as crucial tool this endeavor, offering rapid, low cost detailed analysis cell populations their functional states. Indeed, technology facilitates understanding dysfunctions contributes identification novel biomarkers. Our underscores potential integrating flow with omics data, machine learning observations refine management, highlighting shift towards personalized medicine care. approach could lead more precise interventions, improving outcomes heterogeneously affected population.

Language: Английский

Citations

20