Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Published: Jan. 1, 2024
Increasing evidence indicates that immune disorders contribute to the pathogenesis of depression, however underlying mechanisms and intervention targets remain be determined. Here we found Tim-3, an checkpoint inhibitor, is involved in regulation depression. The expression Tim-3 decreased a mouse depression model induced by chronic restraint stress, specific deletion myeloid cells exacerbated as marked increased cognitive decline. Mechanistically, knock out aggravates neuroimmune inflammation activating NF-κB MAPK pathways. Our results reveal may act potential target promote resilience thus preventing
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: May 14, 2024
infection can trigger high levels of inflammation that lead to fever and sometimes severe disease. People living in malaria-endemic areas gradually develop resistance symptomatic malaria control both parasite numbers the inflammatory response. We previously found adaptive natural killer (NK) cells correlate with reduced load protection from symptoms. also murine NK cell production IL-10 protect mice experimental cerebral malaria. Human secrete IL-10, but it was unknown what subsets produce if this is affected by experience. hypothesize immunoregulation may lower reduce induction. Here, we show subjects experience make significantly more than no then determined proportions are cytotoxic interferon gamma and/or identified a signature checkpoint molecules on IL-10-producing cells. Lastly, find co-culture primary monocytes,
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 28, 2024
SUMMARY Despite the promising results of immune checkpoint blockade (ICB) therapy, outcomes for patients with brain metastasis (BrM) remain poor. Identifying resistance mechanisms has been hindered by limited access to patient samples and relevant preclinical models. Here, we developed two mouse melanoma BrM models that recapitulate disparate responses ICB seen in patients. We demonstrate these capture cellular molecular complexity human disease reveal key factors shaping tumor microenvironment influencing response. BR1-responsive cells express inflammatory programs polarize microglia into reactive states, eliciting robust T cell recruitment. In contrast, BR3-resistant are enriched neurological exploit tolerance maintain homeostasis limit infiltration. humans, BR1 BR3 expression signatures correlate positively or negatively infiltration outcomes, respectively. Our study provides clinically uncovers mechanistic insights responses, offering potential biomarkers therapeutic targets improve therapy efficacy.
Language: Английский
Citations
0
Chinese Journal of Cancer Research, Journal Year: 2024, Volume and Issue: 36(6), P. 616 - 651
Published: Jan. 1, 2024
Exhausted T cell (Tex) is a specific state of dysfunction, in which these cells gradually lose their effector function and change phenotype during chronic antigen stimulation. The enrichment exhausted CD8+ (CD8+ Tex) the tumor microenvironment one important reasons leading to poor efficacy immunotherapy. Recent studies have reported many exhaustion. In addition cancer cells, myeloid can also contribute exhaustion via ways. this review, we discuss history concept exhaustion, dysfunction states, heterogeneity, origin, characteristics Tex. We then focus on effects Tex, including tumor-associated macrophages (TAMs), dendritic (DCs) neutrophils. Finally, systematically summarize current strategies recent advancements therapies reversing
Language: Английский
Citations
0
Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0