Journal of Biological Chemistry, Journal Year: 2023, Volume and Issue: 299(4), P. 104572 - 104572

Published: March 2, 2023

Post-translational modifications (PTMs) regulate all aspects of protein function. Therefore, upstream regulators PTMs, such as kinases, acetyltransferases, or methyltransferases, are potential therapeutic targets for human diseases, including cancer. To date, multiple inhibitors and/or agonists these PTM in clinical use, while others still development. However, control not only the PTMs disease-related target proteins but also other disease-irrelevant substrate proteins. Thus, nontargeted perturbing activities may introduce unwanted off-target toxicity issues that limit use drugs successful applications. alternative solely a specific disease-relevant provide more precise effect treating disease with relatively low side effects. this end, chemically induced proximity has recently emerged powerful research tool, and several chemical inducers (CIPs) have been used to ubiquitination, phosphorylation, acetylation, glycosylation. These CIPs high be translated into examples PROTACs MGDs now trials. Hence, need developed cover types methylation palmitoylation, thus providing full spectrum tools basic application effective cancer treatment. Eukaryotic cells rely on posttranslational activity, stability, subcellular localization, protein–protein interactions (PPIs) (1Beltrao P. Albanèse V. Kenner L.R. Swaney D.L. Burlingame A. Villén J. et al.Systematic functional prioritization modifications.Cell. 2012; 150: 413-425Abstract Full Text PDF PubMed Scopus (306) Google Scholar, 2Walsh G. Jefferis R. context proteins.Nat. Biotechnol. 2006; 24: 1241-1252Crossref (742) 3Deribe Y.L. Pawson T. Dikic I. signal integration.Nat. Struct. Mol. Biol. 2010; 17: 666-672Crossref (541) 4Peng Y. Liu H. Long mitochondrial metabolic enzymes cancer.Free Radic. 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