The Meningeal Lymphatic System: A New Player in Neurophysiology

Neuron, Journal Year: 2018, Volume and Issue: 100(2), P. 375 - 388

Published: Oct. 1, 2018

Language: Английский

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Circadian Rhythms, Sleep, and Disorders of Aging

Trends in Endocrinology and Metabolism, Journal Year: 2016, Volume and Issue: 27(4), P. 192 - 203

Published: March 5, 2016

Language: Английский

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Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus

Trends in Molecular Medicine, Journal Year: 2020, Volume and Issue: 26(3), P. 285 - 295

Published: Jan. 18, 2020

Language: Английский

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Orexinergic System Dysregulation, Sleep Impairment, and Cognitive Decline in Alzheimer Disease

JAMA Neurology, Journal Year: 2014, Volume and Issue: 71(12), P. 1498 - 1498

Published: Oct. 15, 2014

Importance

Nocturnal sleep disruption develops in Alzheimer disease (AD) owing to the derangement of sleep-wake cycle regulation pathways. Orexin contributes by increasing arousal levels and maintaining wakefulness.

Objectives

To study cerebrospinal fluid orexin patients with AD, evaluate relationship degree dementia AD biomarkers (tau proteins β-amyloid 1-42), analyze potentially related architecture changes measured polysomnography.

Design, Setting, Participants

We conducted a case-control from August 1, 2012, through May 31, 2013. included 48 drug-naive referred Neurological Clinic University Hospital Rome Tor Vergata. Based on Mini-Mental State Examination score, 21 were mild group (score, ≥21), whereas 27 moderate severe <21). The control consisted 29 nondemented participants similar age sex.

Exposure

Laboratory assessment orexin, tau proteins, 1-42 polysomnographic variables.

Main Outcomes Measures

Levels 1-42; macrostructural variables nocturnal (total time, efficiency, onset rapid eye movement [REM] latencies, non-REM REM stages, wakefulness after onset); scores.

Results

Patients presented higher mean (SD) compared controls (154.36 [28.16] vs 131.03 [26.55];P < .01) more impaired respect AD. On other hand, global group, positively correlated total protein (r = 0.32;P .03) strictly impairment. Finally, cognitive impairment, as Examination, was structure deterioration.

Conclusions Relevance

Our results demonstrate that, increased are parallel deterioration, which appears be associated decline. Therefore, orexinergic system seems dysregulated its output function appear overexpressed along progression neurodegenerative process. This overexpression may result an imbalance neurotransmitter networks regulating wake-sleep toward promoting

Language: Английский

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Microglia-Mediated Synapse Loss in Alzheimer's Disease

Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 38(12), P. 2911 - 2919

Published: March 21, 2018

Microglia are emerging as key players in neurodegenerative diseases, such Alzheimer's disease (AD). Thus far, microglia have rather been known modulator of neurodegeneration with functions limited to neuroinflammation and release neurotoxic molecules. However, several recent studies demonstrated a direct role "neuro" degeneration observed AD by promoting phagocytosis neuronal, particular, synaptic structures. While some the address involvement β-amyloid peptides process, also indicate that this could occur independent amyloid, further elevating importance AD. Here we review these speculate about possible cellular mechanisms, how they be regulated risk genes sleep. Finally, deliberate on avenues for targeting microglia-mediated synapse loss therapy prevention.Dual Perspectives Companion Paper: Disease Sleep-Wake Disturbances: Amyloid, Astrocytes, Animal Models William M. Vanderheyden, Miranda Lim, Erik S. Musiek, Jason R. Gerstner.

Language: Английский

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