International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2108 - 2108
Published: Feb. 27, 2025
Gliomas, particularly glioblastoma (GBM), are among the most challenging brain tumors due to their complex and dynamic tumor microenvironment (TME). The TME plays a pivotal role in progression, immune evasion, resistance therapy through intricate interactions glioma cells, components, neurons, astrocytes, extracellular matrix, blood-brain barrier. Targeting has demonstrated potential, with immunotherapies such as checkpoint inhibitors neoadjuvant therapies enhancing responses. Nonetheless, overcoming immunosuppressive landscape metabolic adaptations continues pose significant challenges. This review explores diverse cellular molecular mechanisms that shape TME. A deeper understanding of these holds promise for providing novel therapeutic opportunities improve treatment outcomes.
Language: Английский
