Molecular hydrogen as a potential mediator of the antitumor effect of inulin consumption DOI Creative Commons

Victor Pascal‐Moussellard,

Jean‐Pierre Alcaraz,

Stéphane Tanguy

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 3, 2025

Inulin consumption and dihydrogen (H2) administration both exert antitumor effects on preclinical models as well in clinical trials. As H2 is one of the major byproducts inulin fermentation by bacterial species gut microbiota (GM), we hypothesized that could mediate inulin. To provide evidence favor this hypothesis, first determined pattern H2-exposure to which mice are subjected after developed an inhaled hydrogen therapy (H2T) protocol replicating pattern. We then compared circulating immunity a two-week daily gavage with those corresponding H2T. also supplementation H2T implanted melanoma growth infiltration T lymphocytes. induced similar increase CD4+ CD8+ cells. In addition, treatments similarly inhibited tumor growth. These results support mechanism resulting from GM diffuses across intestinal barrier stimulates immunosurveillance responsible for effect.

Language: Английский

Molecular hydrogen as a potential mediator of the antitumor effect of inulin consumption DOI Creative Commons

Victor Pascal‐Moussellard,

Jean‐Pierre Alcaraz,

Stéphane Tanguy

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 3, 2025

Inulin consumption and dihydrogen (H2) administration both exert antitumor effects on preclinical models as well in clinical trials. As H2 is one of the major byproducts inulin fermentation by bacterial species gut microbiota (GM), we hypothesized that could mediate inulin. To provide evidence favor this hypothesis, first determined pattern H2-exposure to which mice are subjected after developed an inhaled hydrogen therapy (H2T) protocol replicating pattern. We then compared circulating immunity a two-week daily gavage with those corresponding H2T. also supplementation H2T implanted melanoma growth infiltration T lymphocytes. induced similar increase CD4+ CD8+ cells. In addition, treatments similarly inhibited tumor growth. These results support mechanism resulting from GM diffuses across intestinal barrier stimulates immunosurveillance responsible for effect.

Language: Английский

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