Infection and Immunity, Journal Year: 2024, Volume and Issue: 92(8)
Published: Aug. 13, 2024
ABSTRACT Interbacterial antagonism involves all major phyla, occurs across the full range of ecological niches, and has great significance for environment, clinical arena, agricultural industrial sectors. Though earliest insight into interbacterial traces back to discovery antibiotics, a paradigm shift happened when it was learned that protein secretion systems (e.g., types VI IV systems) deliver toxic “effectors” against competitors. However, link between Gram-negative type II system (T2SS), which exists in many pathogens environmental species, is not evident prior reviews on bacterial competition or T2SS function. A current examination literature revealed four examples one its known substrates having bactericidal activity Gram-positive target another Gram-negative. When further studied, effectors proved be peptidases peptidoglycan competitor. There are also reports various bacteriolytic enzymes occurring culture supernatants some other these activities suggested. Thus, can mediator antagonism, possible T2SSs have antibacterial outputs. Yet, at present, remains relatively understudied role competition. Arguably, there need analyze broader species their antagonism. Such investigation offers, among things, pathway toward developing new antimicrobials treating disease.
Language: Английский