From sensory organs to internal pathways: A comprehensive review of amino acid sensing in Drosophila

Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology, Journal Year: 2025, Volume and Issue: unknown, P. 111828 - 111828

Published: Feb. 1, 2025

Language: Английский

Humidity determines penetrance of a latitudinal gradient in genetic selection on the microbiota byDrosophila melanogaster

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Abstract The fruit fly Drosophila melanogaster is a model for understanding how hosts and their microbial partners interact as the host adapts to wild environments. These interactions are readily interrogated because of low taxonomic numeric complexity flies’ bacterial communities. Previous work has established that genotype, environment, diet, interspecies can all influence fitness microbiota composition, but specific processes characters mediating these incompletely understood. Here, we compared variation in composition between wild-derived populations when flies could choose microorganisms diets were reared under environmental perturbation (different humidities). We also colonization resident transient microorganisms. show ability diet condition relative abundance microbiota. There key differences abundances However, only differed at humidities or above 50% humidity. elevated humidity determined penetrance gradient genetic selection on associated with latitude collected from. Finally, treatment-dependent stress survival. Together, findings emphasize animal be patterned source geography, such potential survival wild. Importance adapt Our what causes geographic remains incomplete. shown D. relatively numerical complexity. Variation attributed variation, location flies. In this explored three possible composition. feeding choices, niche colonized by bacteria, single character contribute latitudinally-patterned observed humidities. results identify several factors genotypes interplay determining hosts.

Language: Английский

Environment and diet shape the geography-specificDrosophila melanogastermicrobiota composition

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

ABSTRACT Geographic and environmental variation in the animal microbiota can be directly linked to evolution wild fitness of their hosts but often appears disordered. Here, we sought better understand patterns that underlie composition Drosophila melanogaster . First, temperature predicted geographic fly microbial communities than latitude did. The also differed between flies diets, supporting previous conclusions is not merely a reflection diet. Flies feeding on different diets varied significantly composition, sampled from individual apples were exceptionally depauperate for Lactic Acid Bacteria (LAB), major bacterial group laboratory flies. However, bore more LAB when other fruits or compost piles. Follow-up analyses revealed abundance uniquely responds fruit decomposition, whereas members indicate temporal seasonal progression. Finally, show diet-dependent associated with phenotypic differentiation lines collected single orchard. These last findings link covariation flies’ dietary history, genetic across relatively small (single-orchard) landscapes, reinforcing critical role environment-dependent play local adaptation genomic model host. SIGNIFICANCE STATEMENT animals influence hosts’ fitness, it hard predict explain how varies animals. describe ordered by temperature, humidity, distance, diet type. We these determinants help lactic acid bacteria (LAB) flies, including rarity some studies. phenotypes segregate illuminating links host evolution. Together, compositions shape an animal’s life history.

Language: Английский