The 3rd anniversary of Frontiers in Virology: aiming to consolidate the virus research DOI Creative Commons
Akio Adachi, Takaaki Koma, Masako Nomaguchi

et al.

Frontiers in Virology, Journal Year: 2024, Volume and Issue: 4

Published: Oct. 25, 2024

mutability and its wild-bird origin. Experts are really anxious about other terrible influenzapandemics by new type viruses. About 40 years ago, we also encountered another dreadful readily mutable virus HIV-1 that causes AIDS. Since the AIDS outbreak began, approximately 100 million people have been infected with died of AIDS/AIDSrelated diseases. still stays pandemic functional cure is not yet achieved (4-7). Thus, causative needs to be studied in more detail precisely understand viral persistent state humans. Toward this direction, further medical investigation as well fundamental basic research should performed (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). retroviral genome integrates into those humans establish inseparable virus-host relationship, firm solid virological understanding intracellular events particularly required address follow significant numbers pre-clinical clinical issues on And now, witnessing global pandemics caused corona pox viruses (SARS-CoV-2 Mpox virus, respectively) (19)(20)(21)(22)(23)(24)(25)(26)(27)(28). As a matter course, basis previous profound knowledge various viruses, extensive efforts paid biology/molecular biology two valid preventive therapeutic measures. One problem here high adaptability despite their quite low mutation rates (19,28). This observation can explained some specific mechanisms such recombinational mutations (the non-processive replicase-driven template switching mechanism for SARS-CoV-2) (19,29) transient gene duplications accordion model virus) (28,30). In any case, deal mutant appearing course infection.As described above, IFV, HIV-1, SARS-CoV-2, highly adaptable restrictive hostile environments. These dexterous being able ingeniously modify them significantly response variously changing circumstances. Through genomic adaptive and/or own proteins, circumvent barriers cellular anti-viral factors, host natural/acquired immunity against antivirals, vaccines. an example escape than mutations, innately encodes accessory proteins allow it evade restriction factors (31)(32)(33)(34). Collectively, likely frequently change environment-dependent way. So far, know entity concerned only nucleotide sequencings. means running behind just retrospectively following Most virologists including our group adopted strategy due limitations laboratory virology, whereas many biologically results accumulated exploring Our team has investigated adaptation process clarify significance synonymous substitutions structure-function relationship combining experimental virology data/computational science, successfully published obtained series articles (35)(36)(37)(38)(39)(40)(41)(42). On one hand, different from approaches, class studies based big data massive scope scale attracted attention unprecedented concept past decade (43)(44)(45)(46)(47)(48)(49)(50)(51)(52). The characterized methods collect analyze large sets, NSG, CRISPR-based technologies, machine learning, algorithms. targets were: epidemiology disease, plant ecology, evolution, drug-resistance, databases research, computational tools. sciences may aid forecasting future virus-related issues. Big approaches surely synergize consolidate predictive role modern virology."Frontiers Virology" continues platform cutting edge virology. It covers all subjects indicated names specialty sections. Furthermore, "Frontiers appreciates leading-edge technology virusrelated matters. ideal goal prospectively foresee everything effects hosts/environments, beforehand conclusion, earnestly hope submission your important papers scientific value.

Language: Английский

Incompletely closed HIV-1CH040 envelope glycoproteins resist broadly neutralizing antibodies while mediating efficient HIV-1 entry DOI Creative Commons
Durgadevi Parthasarathy,

Stephanie Pickthorn,

Shamim Ahmed

et al.

npj Viruses, Journal Year: 2025, Volume and Issue: 3(1)

Published: Jan. 15, 2025

HIV-1 envelope glycoproteins (Envs) mediate viral entry and are sole target of neutralizing antibodies. Thus, Envs must maintain a delicate balance between evading antibodies while still preserving compatibility to into cells. Here, we studied the effeciency, fitness, replication an incompletely closed, transmitted/founder (CH040), which highly resistant most bnAbs. CH040 mediated cells as efficient other primary Envs, suggesting that antibody resistance can develop independently. Expression was comparable variants were rationally engineered increase bnAb showed no significant decrease in their ability entry. We detected robust vitro spread SHIV pig-tailed macaque lymphocytes SHIVs. Our study provides insights relationship

Language: Английский

Citations

0
Progress and Challenges in HIV-1 Vaccine Research: A Comprehensive Overview DOI Creative Commons
Alex Boomgarden, Chitra Upadhyay

Vaccines, Journal Year: 2025, Volume and Issue: 13(2), P. 148 - 148

Published: Jan. 31, 2025

The development of an effective HIV-1 vaccine remains a formidable challenge in biomedical research. Despite significant advancements our understanding HIV biology and pathogenesis, progress has been impeded by factors such as the virus's genetic diversity, high mutation rates, its ability to establish latent reservoirs. Recent innovative approaches, including mosaic vaccines mRNA technology induce broadly neutralizing antibodies, have shown promise. However, efficacy these modest, with best results achieving approximately 30% effectiveness. Ongoing research emphasizes necessity multifaceted strategy overcome obstacles achieve breakthrough development. This review summarizes current approaches utilized further understand create global vaccine. We discuss impact on for other diseases, COVID-19, influenza, Zika virus. Additionally, we highlight specific limitations faced each approach present methods researchers employ challenges. These techniques, which demonstrated preclinical clinical success, advanced field closer ultimate goal developing Leveraging will enable strides combating infectious ultimately improving health outcomes.

Language: Английский

Citations

0
Promising Strategies for Accelerating the Eradication of Avian Leukosis in China DOI Creative Commons
Tuofan Li, Jingwen Li, Zeming Wang

et al.

Animals and zoonoses., Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
mRNA-based vaccines and therapies - a revolutionary approach for conquering fast-spreading infections and other clinical applications: a review DOI

Mingyue Pan,

Weiling Cao, Jingbo Zhai

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143134 - 143134

Published: April 1, 2025

Language: Английский

Citations

0
The 3rd anniversary of Frontiers in Virology: aiming to consolidate the virus research DOI Creative Commons
Akio Adachi, Takaaki Koma, Masako Nomaguchi

et al.

Frontiers in Virology, Journal Year: 2024, Volume and Issue: 4

Published: Oct. 25, 2024

mutability and its wild-bird origin. Experts are really anxious about other terrible influenzapandemics by new type viruses. About 40 years ago, we also encountered another dreadful readily mutable virus HIV-1 that causes AIDS. Since the AIDS outbreak began, approximately 100 million people have been infected with died of AIDS/AIDSrelated diseases. still stays pandemic functional cure is not yet achieved (4-7). Thus, causative needs to be studied in more detail precisely understand viral persistent state humans. Toward this direction, further medical investigation as well fundamental basic research should performed (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). retroviral genome integrates into those humans establish inseparable virus-host relationship, firm solid virological understanding intracellular events particularly required address follow significant numbers pre-clinical clinical issues on And now, witnessing global pandemics caused corona pox viruses (SARS-CoV-2 Mpox virus, respectively) (19)(20)(21)(22)(23)(24)(25)(26)(27)(28). As a matter course, basis previous profound knowledge various viruses, extensive efforts paid biology/molecular biology two valid preventive therapeutic measures. One problem here high adaptability despite their quite low mutation rates (19,28). This observation can explained some specific mechanisms such recombinational mutations (the non-processive replicase-driven template switching mechanism for SARS-CoV-2) (19,29) transient gene duplications accordion model virus) (28,30). In any case, deal mutant appearing course infection.As described above, IFV, HIV-1, SARS-CoV-2, highly adaptable restrictive hostile environments. These dexterous being able ingeniously modify them significantly response variously changing circumstances. Through genomic adaptive and/or own proteins, circumvent barriers cellular anti-viral factors, host natural/acquired immunity against antivirals, vaccines. an example escape than mutations, innately encodes accessory proteins allow it evade restriction factors (31)(32)(33)(34). Collectively, likely frequently change environment-dependent way. So far, know entity concerned only nucleotide sequencings. means running behind just retrospectively following Most virologists including our group adopted strategy due limitations laboratory virology, whereas many biologically results accumulated exploring Our team has investigated adaptation process clarify significance synonymous substitutions structure-function relationship combining experimental virology data/computational science, successfully published obtained series articles (35)(36)(37)(38)(39)(40)(41)(42). On one hand, different from approaches, class studies based big data massive scope scale attracted attention unprecedented concept past decade (43)(44)(45)(46)(47)(48)(49)(50)(51)(52). The characterized methods collect analyze large sets, NSG, CRISPR-based technologies, machine learning, algorithms. targets were: epidemiology disease, plant ecology, evolution, drug-resistance, databases research, computational tools. sciences may aid forecasting future virus-related issues. Big approaches surely synergize consolidate predictive role modern virology."Frontiers Virology" continues platform cutting edge virology. It covers all subjects indicated names specialty sections. Furthermore, "Frontiers appreciates leading-edge technology virusrelated matters. ideal goal prospectively foresee everything effects hosts/environments, beforehand conclusion, earnestly hope submission your important papers scientific value.

Language: Английский

Citations

0