Eosinophils Enhance Granuloma-Mediated Control of Persistent Salmonella Infection
Abstract
Salmonella
enterica
can
persist
asymptomatically
within
tissues
for
extended
periods.
This
remarkable
feat
is
achieved
through
intricate
host-pathogen
interactions
in
immune
cell
aggregates
called
granulomas,
wherein
Salmonella
find
favorable
cellular
niches
to
exploit
while
the
host
limits
its
expansion
and
tissue
dissemination.
Here,
using
a
mouse
model
of
persistent
infection,
we
identify
host-protective
role
eosinophils
control
Typhimurium
(S Tm)
infection
mesenteric
lymph
nodes
(MLN),
main
lymphoid
S Tm
persistence.
Combining
spatial
transcriptomics
experimental
manipulations,
found
that
macrophages
responding
recruited
C-C
motif
chemokine
ligand
11
(CCL11)-dependent
manner
enhanced
their
activation.
Eosinophil
deficiencies
increased
burdens,
which
was
associated
with
altered
granuloma
size
impaired
type-1
immunity
MLN.
Thus,
play
vital
restraining
exploitation
at
key
site
bacterial
Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Language: Английский