Identification and characterization of a Relish-type NF-κB, DvRelish, in Dermacentor variabilis in response to Rickettsia rickettsii infection DOI Creative Commons
Chanida Fongsaran, Victoria I. Verhoeve,

Krit Jirakanwisal

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 15, 2024

Ixodid ticks serve as hosts and transmission vectors for several obligate intracellular bacteria, including members of the spotted fever group (SFG) Rickettsia . Although generate an immune response to bacterial insults, many signaling molecules associated with how they may contribute vector competence are undefined. In this study, we isolated a full-length dvrelish transcript from Dermacentor variabilis , which encoded Relish-type NF-κB. The presence canonical Rel homology domain (RHD) consistent NF-κB proteins suggested role in tick DvRelish. expression DvRelish was confirmed tissues fluorescent microscopy hemocytes indicated increased following infection compared non-tick-borne pathogen. To further determine effect dvRelish gene knockdown on rickettsial infection, used RNA interference-mediated D. demonstrated that transcription decreased after 24 h post-injection siRNA. We then assessed when exposed rickettsii determined inversely loads at 48 post-exposure. Further studies required broaden understanding differential responses SFG elucidate played by arthropod system competence.

Language: Английский

Mast cell-mediated immune regulation in health and disease DOI Creative Commons

Kottarappat N. Dileepan,

Vineesh V. Raveendran, Rishi Sharma

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Aug. 17, 2023

Mast cells are important components of the immune system, and they perform pro-inflammatory as well anti-inflammatory roles in complex process regulation health disease. Because their strategic perivascular localization, sensitivity adaptability to microenvironment, ability release a variety preformed newly synthesized effector molecules, mast unique functions almost all organs. Additionally, express wide range surface cytoplasmic receptors which enable them respond cytokines, chemicals, pathogens. The cell’s role cellular interface between external internal environments vasculature tissues is critical for protection repair. cell interactions with different nonimmune through secreted inflammatory mediators may also turn favor disease promoting agents. First forefront, recognized multifaceted allergic diseases. Reciprocal communication endothelial presence bacterial toxins chronic/sub-clinical infections induce persistent vascular inflammation. We have shown that proteases histamine responses synergistically amplified by toxins. been exacerbate changes normal states chronic or subclinical infections, particularly among cigarette smokers. Furthermore, potential SARS-CoV-2-induced dysfunction capillary-alveolar adds growing understanding viral infections. interaction microglial brain further highlights significance neuroinflammation. This review significant acts sensor early responder systemic organs nervous system.

Language: Английский

Citations

41
Pathogenic Rickettsia spp. as emerging models for bacterial biology DOI Creative Commons
Brandon Sit, Rebecca L. Lamason

Journal of Bacteriology, Journal Year: 2024, Volume and Issue: 206(2)

Published: Feb. 5, 2024

Our understanding of free-living bacterial models like

Language: Английский

Citations

9
Tick species, tick-borne pathogen distribution and risk factor analysis in border areas of China, Russia and North Korea DOI Creative Commons

Pengfei Min,

Jin‐Won Song,

Shaowei Zhao

et al.

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 11, 2025

Introduction Ticks are important ectoparasites of livestock. and tick-borne diseases (TBDs) cause losses to the animal husbandry industry also present a major hidden danger public health safety. However, tick species prevalence TBDs in border regions China, Russia, North Korea remain unknown. The purpose this study was identify pathogens endemic these regions. Methods Morphological molecular identification ticks performed by microscopy polymerase chain reaction (PCR), distribution species, pathogen, risk factors infection were analyzed. Results In total, 1,187 collected from areas 13 localities eight cities. Five identified: Haemaphysalis longicornis (39.68%), Ixodes persulcatus (25.36%), japonica (15.50%), Dermacentor silvarum (15.42%), concinna (4.04%). There more female than male ticks, nymphs least frequently collected. I. main forest environment, while H. grasslands surface. Four detected: Rickettsia , Bartonella Anaplasma Babesia . Discussion Pathogen detection differed significantly among environments between Sexes. significant differences proportion infected with regions, sexes, environments. results survey provided scientific basis for prevention control TBDs.

Language: Английский

Citations

1
Rickettsioses in Colombia during the 20th century: A historical review DOI Creative Commons
Jerson Andrés Cuéllar-Sáenz, Álvaro A. Faccini‐Martínez, Alejandro Ramírez‐Hernández

et al.

Ticks and Tick-borne Diseases, Journal Year: 2023, Volume and Issue: 14(2), P. 102118 - 102118

Published: Jan. 1, 2023

Rickettsioses are vector-borne zoonotic diseases whose etiological agents bacteria of the genera Rickettsia and Orientia. In Colombia, literature published on rickettsioses during 20th century is limited disperse; to date, there no detailed publications that compile affected regions or involved species in each outbreak. Since early works Luis Patiño-Camargo, study gained major importance with subsequent description significant outbreaks some departments country. During 1940s, many articles were reporting probably caused by rickettsii, typhi, prowazekii, as well studies their diagnosis, vaccination, prophylaxis. One most notorious was Patiño-Camargo where he named R. rickettsii rickettsiosis "Tobia fever". However, decades, these entities entered a prolonged period neglected research surveillance, just until 21st century, when new fatal cases began be reported country; thus, questions remained unanswered this overlooked period. The present work reviewed online databases, repositories, libraries related Colombia century. Gathered data show typhus group (including infections typhi prowazekii) broadly distributed from Andean Caribbean regions, spotted fever rickettsii) registered other locations different Tobia (Cundinamarca), like Atlántico, Bolivar, Santander departments. These findings contribute knowledge diseases, historical distribution, public health burden, set horizons for Colombian locations.

Language: Английский

Citations

13
Tick symbiosis DOI

Zhengwei Zhong,

Kun Wang,

Jingwen Wang

et al.

Current Opinion in Insect Science, Journal Year: 2024, Volume and Issue: 62, P. 101163 - 101163

Published: Jan. 18, 2024

Language: Английский

Citations

4
Molecular and next-generation sequencing analysis of tick-borne pathogens of Rhipicephalus ticks (Acari: Ixodidae) in cattle and dogs DOI
Jitrawadee Intirach, Xin Lv, Nataya Sutthanont

et al.

Acta Tropica, Journal Year: 2024, Volume and Issue: 252, P. 107138 - 107138

Published: Feb. 1, 2024

Language: Английский

Citations

4
Tissue-specific localization of tick-borne pathogens in ticks collected from camels in Kenya: insights into vector competence DOI Creative Commons
Rua Khogali, Armanda D. S. Bastos, Joel L. Bargul

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: April 18, 2024

Tick-borne pathogen (TBP) surveillance studies often use whole-tick homogenates when inferring tick-pathogen associations. However, localized TBP infections within tick tissues (saliva, hemolymph, salivary glands, and midgut) can inform transmission mechanisms are key to disentangling detection from vector competence. We screened 278 camel blood samples 504 tissue derived 126 ticks sampled in two Kenyan counties (Laikipia Marsabit) for Anaplasma, Ehrlichia, Coxiella, Rickettsia, Theileria, Babesia by PCR-HRM analysis. Candidatus Anaplasma camelii were common camels (91%), but absent all Rhipicephalus pulchellus, Amblyomma gemma, Hyalomma dromedarii, rufipes ticks. detected Ehrlichia ruminantium of the four species, Rickettsia aeschlimannii was only found Hy. (all tissues). africae highest Am. gemma (62.5%), mainly hemolymph (45%) less frequently midgut (27.5%) lowest Rh. pulchellus (29.4%), where rates 17.6% 11.8%, respectively. Similarly, R. (41.7%) hemolymph. not rufipes. No or spp. this study. The tissue-specific localization africae, is congruent with role species as its vector. Thus, occurrence TBPs could serve a predictor competence transmission, especially comparison midgut, which they must cross barriers effectively replicate disseminate across tissues. Further should focus on exploring distribution enhance knowledge epidemiology distinguish competent vectors dead-end hosts.

Language: Английский

Citations

3
Differential interactions of Rickettsia species with tick microbiota in Rh. sanguineus and Rh. turanicus DOI Creative Commons
Apolline Maître, Myriam Kratou,

Ivan Corona-Guerrero

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 5, 2024

Language: Английский

Citations

3
Current Tick Control Strategies and Prospects for Using Nanotechnology as an Efficient Alternative—A Review DOI Creative Commons
Rafaela Regina Fantatto, João Vitor Carvalho Constantini, Flávio Augusto Sanches Politi

et al.

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(2), P. 163 - 163

Published: Feb. 12, 2025

Ticks pose significant challenges to public and veterinary health, acting as vectors of several diseases that affect animals humans. Traditional chemical control methods, such pyrethroids organophosphates, have led increasing resistance environmental contamination, highlighting the need urgency for alternative strategies. This review explores contemporary approaches tick control, emphasizing plant-derived acaricides their integration with nanotechnology. Plant extracts, known acaricidal properties, disrupt biological processes in ticks, reducing reproduction survival rates. The advent nanotechnology offers promising advances efficacy these natural extracts. Nanoparticles add properties systems where they act by improving stability, bioavailability, targeted delivery compounds, potentially overcoming limitations traditional acaricides. synthesis current knowledge highlights potential combining plant extracts develop sustainable effective solutions, addressing issues acaricide well concerns. also identifies research gaps suggests directions future studies optimize application management.

Language: Английский

Citations

0
Serologic and molecular survey for Rickettsia in small mammals in the Andes of Colombia DOI Creative Commons
Johnathan Alvarez‐Londoño, Estefani T. Martínez‐Sánchez,

Mariana Aristizábal-Mier

et al.

Acta Tropica, Journal Year: 2025, Volume and Issue: unknown, P. 107589 - 107589

Published: March 1, 2025

Zoonotic vector-borne infectious diseases represent a significant global challenge. Ticks are one of the most important vectors globally, transmitting wide range pathogens. Among these pathogens, bacteria genus Rickettsia cause zoonotic diseases, knows as rickettsioses, that primarily affect tropical and subtropical regions. Rickettsiae transmitted between vertebrate hosts vectors, with some wild mammals serving key amplifying hosts. In Colombia, limited information on reservoirs contrasts their high diversity, which includes 551 native mammal species, 51 species ticks associated To detect exposure infections in from Colombian Andean region, serum, blood, organ samples were collected Departments Caldas Risaralda, July 2021 November 2022. A total 147 belonging to 58 three orders (Didelphimorphia, Chiroptera, Rodentia) captured. The indirect immunofluorescence assays analysis detected antibodies for 100% didelphids, 65.2% rodents, 45.9% bats. DNA was 4.1% analyzed, 'Candidatus andeanae', felis, rickettsii, parkeri identified rodents detection reinforces role highlights need investigate ecology improve surveillance control rickettsiosis Colombia.

Language: Английский

Citations

0