Pathogens, Journal Year: 2023, Volume and Issue: 12(10), P. 1253 - 1253
Published: Oct. 18, 2023
Severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) emerged in a live animal market the Hubei Province of Wuhan China late 2019 and was declared pandemic by World Health Organization (WHO) on 11 March 2020 [...].
Language: Английский
JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(8), P. e2328928 - e2328928
Published: Aug. 15, 2023
Approximately one-third of the more than 1 100 000 confirmed COVID-19-related deaths as January 18, 2023, were considered preventable if public health recommendations had been followed. Physicians' propagation misinformation about COVID-19 on social media and other internet-based platforms has raised professional, health, ethical concerns.To characterize (1) types propagated by US physicians after vaccines became available, (2) online used, (3) characteristics spreading misinformation.Using Centers for Disease Control Prevention guidelines prevention treatment infection during study window to define misinformation, structured searches high-use (Twitter, Facebook, Instagram, Parler, YouTube) news sources (The New York Times, National Public Radio) conducted identify communicated US-based between 2021 December 2022. state licensure medical specialty identified. The number followers each physician 4 major was extracted estimate reach qualitative content analysis messages performed.Outcome measures included categories propagated, traits engaged in propagation, type channels used propagate potential reach.The attributed 52 28 different specialties across all regions country. General vaccines, medication, masks, (ie, conspiracy theories). Forty-two (80.8%) posted vaccine 40 (76.9%) information category, 20 (38.5%) 5 or platforms. Major themes identified disputing safety effectiveness, promoting treatments lacking scientific evidence and/or Food Drug Administration approval, mask-wearing (4) (unsubstantiated claims, eg, virus origin, government lies, theories).In this mixed-methods media, results suggest widespread, inaccurate, potentially harmful assertions made country who represented a range subspecialties. Further research is needed assess extent harms associated with motivations these behaviors, legal professional recourse improve accountability propagation.
Language: Английский
Citations
56
Eye, Journal Year: 2024, Volume and Issue: 38(11), P. 2014 - 2027
Published: Feb. 14, 2024
Abstract Infectious diseases affecting the eye often cause unilateral or asymmetric visual loss in children and people of working age. This group conditions includes viral, bacterial, fungal parasitic diseases, both common rare presentations which, aggregate, may account for a significant portion global burden. Diagnosis is frequently challenging even specialist centres, many disease are highly regional. In an age globalisation, understanding various modes transmission geographic distribution infections can be instructive to clinicians. The impact on disability currently not sufficiently captured prevalence studies impairment blindness, which focus bilateral over-50s. Moreover, cases it hard differentiate between infectious immune-mediated diseases. Since preventable affect younger people, we argue that future they should considered as separate category, including estimates disability-adjusted life years (DALY) measure overall Numbers ocular uniquely affected by outbreaks well endemic transmission, their control relies collaborative partnerships go beyond remit ophthalmology, encompassing domains vaccination, antibiotic development, individual healthcare, vector control, mass drug administration, food supplementation, environmental hygiene, epidemiological mapping, more. anticipated impacts warming, conflict, poverty, urbanisation degradation likely magnify importance. While remote telemedicine useful aide diagnosis these resource-poor areas, enhanced reporting networks artificial intelligence systems ultimately required surveillance monitoring.
Language: Английский
Citations
14
Risk Analysis, Journal Year: 2024, Volume and Issue: 44(8), P. 1896 - 1906
Published: March 15, 2024
The origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is contentious. Most studies have focused on a zoonotic origin, but definitive evidence such as an intermediary animal host lacking. We used established risk analysis tool for differentiating natural and unnatural epidemics, the modified Grunow-Finke assessment (mGFT) to study SARS-COV-2. mGFT scores 11 criteria provide likelihood or origin. Using published literature publicly available sources information, we applied SARS-CoV-2. scored 41/60 points (68%), with high inter-rater reliability (100%), indicating greater than This cannot prove SARS-CoV-2 shows that possibility laboratory be easily dismissed.
Language: Английский
Citations
13
Journal of Virology, Journal Year: 2024, Volume and Issue: 98(9)
Published: Aug. 1, 2024
Science is humanity's best insurance against threats from nature, but it a fragile enterprise that must be nourished and protected. The preponderance of scientific evidence indicates natural origin for SARS-CoV-2. Yet, the theory SARS-CoV-2 was engineered in escaped lab dominates media attention, even absence strong evidence. We discuss how resulting anti-science movement puts research community, research, pandemic preparedness at risk.
Language: Английский
Citations
7
Published: Feb. 11, 2025
The emergence of SARS-CoV-2 in late 2019 triggered a global pandemic (COVID-19) that has claimed millions lives and continues to impact public health systems worldwide. This review examines current scientific evidence regarding the virus's origins, focusing on two primary hypotheses: zoonotic spillover laboratory-related emergence. A comprehensive analysis peer-reviewed literature published between December 2023 January 2025 was conducted, identifying relevant studies through searches PubMed Scopus databases. revealed strong phylogenetic supporting natural origin, with several indicating close genetic relationships bat coronaviruses. Environmental sampling data from Huanan Seafood Market detected RNA high number environmental samples animal stalls. While preponderance supports spillover, absence definitively identified intermediate host maintains some uncertainty. concludes evidence-based recommendations for enhanced viral surveillance, implementation One Health approaches, strengthened international collaboration frameworks prevent future coronavirus pandemics.
Language: Английский
Citations
0
Published: Feb. 17, 2025
The emergence of SARS-CoV-2 in late 2019 triggered a global pandemic (COVID-19) that has claimed millions lives and continues to impact public health systems worldwide. This review examines current scientific evidence regarding the virus's origins, focusing on two primary hypotheses: zoonotic spillover laboratory-related emergence. A comprehensive analysis peer-reviewed literature primarily published between December 2023 January 2025 was conducted, identifying relevant studies through searches PubMed Scopus databases. Key earlier publications are also included provide essential background context. revealed strong phylogenetic supporting natural origin, with several indicating close genetic relationships bat coronaviruses. Environmental sampling data from Huanan Seafood Market detected RNA high number environmental samples animal stalls. While preponderance supports spillover, absence definitively identified intermediate host maintains some uncertainty. concludes evidence-based recommendations for enhanced viral surveillance, implementation One Health approaches, strengthened international collaboration frameworks prevent future coronavirus pandemics.
Language: Английский
Citations
0
Published: Feb. 19, 2025
The emergence of SARS-CoV-2 in late 2019 triggered a global pandemic (COVID-19) that has claimed millions lives and continues to impact public health systems worldwide. This review examines current scientific evidence regarding the virus's origins, focusing on two primary hypotheses: zoonotic spillover laboratory-related emergence. A comprehensive analysis peer-reviewed literature primarily published between December 2023 January 2025 was conducted, identifying relevant studies through searches PubMed Scopus databases. Key earlier publications are also included provide essential background context. revealed strong phylogenetic supporting natural origin, with several indicating close genetic relationships bat coronaviruses. Environmental sampling data from Huanan Seafood Market detected RNA high number environmental samples animal stalls. While preponderance supports spillover, absence definitively identified intermediate host maintains some uncertainty. concludes evidence-based recommendations for enhanced viral surveillance, implementation One Health approaches, strengthened international collaboration frameworks prevent future coronavirus pandemics.
Language: Английский
Citations
0
Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(2)
Published: Feb. 1, 2025
ABSTRACT Immunoassays represent sensitive, easy‐to‐use, and cost‐effective tests useful for the detection of SARS‐CoV‐2 virus. In this manuscript, we report on binding specificity a pair novel monoclonal antibodies (MAbs) generated against nucleocapsid protein (NP) their development into sensitive sandwich enzyme‐linked immunosorbent assays (sELISA) lateral flow immunoassay (LFIA). Binding these MAbs to hCoVs is limited variants SARS‐CoV NP. Chemiluminescent absorbance spectroscopy sELISAs limit (LOD) B.1.1.529 NP variant at 15 pg/mL, LFIA using red‐dyed 200 nm particle 10 ng/mL. The sELISA exhibits broad viral with assay LOD virus 1.4 × 5 genome copies per mL ( p ≤ 0.001). availability should facilitate continued investment in commercial immunoassays increase global technologies.
Language: Английский
Citations
0
BMJ, Journal Year: 2025, Volume and Issue: 389, P. r806 - r806
Published: April 23, 2025
Language: Английский
Citations
0
Journal of Medical Microbiology, Journal Year: 2024, Volume and Issue: 73(2)
Published: Feb. 2, 2024
The coronavirus disease 2019 pandemic accelerated developments in biotechnology that underpin infection science. These advances present an opportunity to refresh the microbial forensic toolkit. Integration of novel analytical techniques with established methods will speed up acquisition evidence and better support lines enquiry. A critical part any such investigation is demonstration a robust causal relationship attribution responsibility for incident. In wider context formal into agency, motivation intent, quick efficient assembly microbiological sets tone tempo entire investigation. from science systematic approach forensics therefore ensure major perspectives are correctly used frame shape clear narrative, while recognizing hypothesis generation, testing refinement comprise iterative process. Development multidisciplinary training exercises use this enable translation practice implementation when need arises.
Language: Английский
Citations
1