Novel designed analogues of quercetin against SARS-CoV2:an in-silico pharmacokinetic evaluation, molecular modeling, MD simulations based study

Journal of Biomolecular Structure and Dynamics, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 19

Published: Oct. 5, 2023

Here we present the design of series quercetin analogues and their molecular docking study involving binding its with SARS-CoV2 3CLpro. The scientific literature shows that compound has been successfully used against SARS-CoV by inhibiting replication virus in respiratory epithelial cell through inhibition main protease (3CLpro.) It was suggested modification at position 3 structure may produce potent compounds SARS-CoV2. A were designed screened for physicochemical pharmacokinetics parameters. activities selected modelling evaluated analogues, Q5, Q6 Q13 have best scores (-8.01 to -8.17 kcal/mol) also better than quercetin, α-ketoamide current available inhibitors same target. structure-activity relationship (SAR) revealed introduction amino group a molecule highly promising increasing inhibitory activity 3CL pro. Moreover, check stability orientation inside pocket, dynamic simulations performed 100 ns. Results Q1, having lowest energies (-8.0, -8.06 kcal/mol respectively) as well properties, pharmacokinetics, toxicity profile show potential synthesize develop therapeutic agents corona virus.Communicated Ramaswamy H. Sarma.

Language: Английский

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Her Parasites: A poetic ecospiritual perspective of the COVID-19 pandemic and nature's intelligence

Journal of Ecohumanism, Journal Year: 2024, Volume and Issue: 3(2), P. 189 - 213

Published: March 1, 2024

In this transdisciplinary perspective, I present my initial ecospiritual thinking about the COVID-19 pandemic in a poem, titled Her Parasites. identify with other thinkers – both those science and not who articulated ecophilosophical musings various ways, some of whom were met mockery censure. hope that it will inspire openness sense curiosity, draw on metaphysical insights from Vedic treatises literature environmental decline, zoonotic epidemiology, health science, animal agriculture, ethics, sentience to explain poem’s philosophical ecological framework. focus scientific knowledge epidemics caused by viruses transcend species boundaries, why cross-species hopping occurs, nature (and incredible intelligence) such viruses. invite readers consider ancient principles articulate rationale for living harmoniously sentient beings entities. Considering unseen association between cruelty explained through laws Karmā, possibility one lessons Mother Earth might have wanted Homo sapiens learn is its need alter diet. end discussion value change. The downplaying or denial (strategies overcome psychological discomfort incongruence loving animals eating them, as described social psychology), barrier However, observed lens, cognitive dissonance suggests innately humane, realisation which hold key dietary

Language: Английский

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The Ginkgo—Covid connection

Plants People Planet, Journal Year: 2024, Volume and Issue: 6(6), P. 1224 - 1230

Published: Aug. 17, 2024

Social Impact Statement Gingko biloba is an iconic tree with a surprising connection to the SARS and Covid viruses that have impacted human health since 2003. Natural history studies on ecology of seed dispersal by Carnivoran scavengers in Asia over past 30 plus years elucidated deep evolutionary not only makes these animals effective at spreading seeds but also predisposes them become intermediate hosts for diseases humans. Understanding behavioral traits underlie kinds plant–animal interactions has potential help people limit spread future spillover diseases. Summary Raccoon dogs masked palm civets are native Eastern been documented feeding malodorous sarcotesta Ginkgo effectively dispersing hard nuts they contain. Research shown their immune systems genetically enhanced protect from disease‐causing organisms might pick up omnivorous diets include live dead animals. Both species farmed fur meat across China and, until recently, were commonly sold “wet” markets. determined civet played role virus humans 2003 raccoon dog may similar Wuhan 2019, although this proven. In areas where cultivated, there numerous internet reports Carnivorans its indicating strategy attracting mimicking smell carrion adaptive effective.

Language: Английский

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The COVID-19 Pandemic as a Historical Event: An Analysis of U.S. History Textbooks

Journal of Education, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

This study focuses on how four U.S. History textbooks portrayed the COVID-19 pandemic as a recent historical event. The findings from suggest that provided disjointed narrative did not fully explain aspects of pandemic, such why caused so much societal upheaval. also often dodged significant questions about origin virus and lessons learned response. As such, article concludes by arguing these “first drafts history” will do little to help future generations think critically pandemic.

Language: Английский

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Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”

mBio, Journal Year: 2023, Volume and Issue: 14(3)

Published: April 25, 2023

Language: Английский

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Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”

Journal of Virology, Journal Year: 2023, Volume and Issue: 97(5)

Published: April 25, 2023

Language: Английский

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Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”

mSphere, Journal Year: 2023, Volume and Issue: 8(3)

Published: April 25, 2023

Language: Английский

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A Brief Focus on SARS-CoV-2 Genomic Evolution and Vaccines

Pathogens, Journal Year: 2023, Volume and Issue: 12(10), P. 1253 - 1253

Published: Oct. 18, 2023

Severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) emerged in a live animal market the Hubei Province of Wuhan China late 2019 and was declared pandemic by World Health Organization (WHO) on 11 March 2020 [...].

Language: Английский

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