Journal of Thoracic Disease, Journal Year: 2025, Volume and Issue: 17(3), P. 1698 - 1710
Published: March 1, 2025
Pulmonary arterial hypertension (PAH) is a complex disease that associated with poor prognosis. Its pathogenesis attributed to the inflammatory immune response. Interferon regulator factor 1 (IRF1) key downstream of inflammation and cell death. Evidence suggests IRF1 can promote proliferation smooth muscle cells inhibit lung endothelial regeneration. However, proof for this relationship lacking, exact nature potential mechanism underlying link between PAH remains largely unknown. We aimed find out whether progression PAH. The GSE144274 GSE243193 datasets were obtained from Gene Expression Omnibus database. Differentially expressed genes (DEGs) healthy samples identified analyzed. Enrichment analysis was performed, protein-protein interaction (PPI) network constructed identify hub genes. relative protein gene levels then validated in animal models. A total 271 DEGs two data sets. ACTA2, HLA-DRA, HLA-A, PECAM1, HLA-C, IRF1, CD74 as In our subsequent experiments, we found upregulated both rat mouse Our findings suggest might be pulmonary tissue may thus serve therapeutic target
Language: Английский