Association of interferon regulator factor 1 upregulation with pulmonary arterial hypertension DOI Open Access

Yuheng Ye,

Hui Zhou, Di Yin

et al.

Journal of Thoracic Disease, Journal Year: 2025, Volume and Issue: 17(3), P. 1698 - 1710

Published: March 1, 2025

Pulmonary arterial hypertension (PAH) is a complex disease that associated with poor prognosis. Its pathogenesis attributed to the inflammatory immune response. Interferon regulator factor 1 (IRF1) key downstream of inflammation and cell death. Evidence suggests IRF1 can promote proliferation smooth muscle cells inhibit lung endothelial regeneration. However, proof for this relationship lacking, exact nature potential mechanism underlying link between PAH remains largely unknown. We aimed find out whether progression PAH. The GSE144274 GSE243193 datasets were obtained from Gene Expression Omnibus database. Differentially expressed genes (DEGs) healthy samples identified analyzed. Enrichment analysis was performed, protein-protein interaction (PPI) network constructed identify hub genes. relative protein gene levels then validated in animal models. A total 271 DEGs two data sets. ACTA2, HLA-DRA, HLA-A, PECAM1, HLA-C, IRF1, CD74 as In our subsequent experiments, we found upregulated both rat mouse Our findings suggest might be pulmonary tissue may thus serve therapeutic target

Language: Английский

Hijacking the Autophagy-Apoptosis Crosstalk: African Swine Fever Virus Orchestrates Immune Evasion via Host Remodeling for Viral Pathogenesis DOI
Simeng Zhang, Tiancheng Zhang, Zheng Cao

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107609 - 107609

Published: April 1, 2025

Language: Английский

Citations

0
Shrimp autophagy receptor protein PvTAX1BP1 regulates autophagy and facilitates white spot syndrome virus replication in Penaeus vannamei DOI

Vorawit Ananphongmanee,

Suttipong Tungwaravut,

Warumporn Yingsunthonwattana

et al.

Fish & Shellfish Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110386 - 110386

Published: April 1, 2025

Language: Английский

Citations

0
Association of interferon regulator factor 1 upregulation with pulmonary arterial hypertension DOI Open Access

Yuheng Ye,

Hui Zhou, Di Yin

et al.

Journal of Thoracic Disease, Journal Year: 2025, Volume and Issue: 17(3), P. 1698 - 1710

Published: March 1, 2025

Pulmonary arterial hypertension (PAH) is a complex disease that associated with poor prognosis. Its pathogenesis attributed to the inflammatory immune response. Interferon regulator factor 1 (IRF1) key downstream of inflammation and cell death. Evidence suggests IRF1 can promote proliferation smooth muscle cells inhibit lung endothelial regeneration. However, proof for this relationship lacking, exact nature potential mechanism underlying link between PAH remains largely unknown. We aimed find out whether progression PAH. The GSE144274 GSE243193 datasets were obtained from Gene Expression Omnibus database. Differentially expressed genes (DEGs) healthy samples identified analyzed. Enrichment analysis was performed, protein-protein interaction (PPI) network constructed identify hub genes. relative protein gene levels then validated in animal models. A total 271 DEGs two data sets. ACTA2, HLA-DRA, HLA-A, PECAM1, HLA-C, IRF1, CD74 as In our subsequent experiments, we found upregulated both rat mouse Our findings suggest might be pulmonary tissue may thus serve therapeutic target

Language: Английский

Citations

0