m6A-modified RIOK3 activated the NF-κB-signaling pathway by CDC42, promoting the replication and proliferation of enterovirus
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
unknown, P. 140988 - 140988
Published: Feb. 1, 2025
Language: Английский
Roles of circRNAs in viral pathogenesis
Jiayin Liu,
No information about this author
Yiming Wang,
No information about this author
Meichun Zheng
No information about this author
et al.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: March 13, 2025
Circular
RNAs
(circRNAs)
are
a
class
of
non-coding
with
covalently
closed
circular
structure,
lacking
5’-caps
or
3’-poly(A)
tails.
They
relatively
conserved,
highly
stable,
and
often
exhibit
tissue-
cell-specific
production
in
eukaryotic
cells.
Based
on
the
advances
sequencing
technologies
bioinformatics,
multiple
reports
have
suggested
that
viruses
other
microorganisms
may
encode
circRNA-like
molecules,
providing
new
insights
into
physiological
pathological
roles
circRNAs.
The
innate
immune
system
functions
as
body’s
primary
defense
mechanism
against
viral
infections.
It
detects
pathogen-associated
molecular
patterns
(PAMPs)
activates
signaling
pathways
to
suppress
replication
limit
their
spread.
CircRNAs
involved
regulation
host
play
essential
pathogenesis.
has
been
shown
circRNAs
can
regulate
gene
expression
by
acting
miRNA
sponges
protein
sponges,
encoding
small
proteins
specific
cases.
For
example,
previous
studies
revealed
participate
antiviral
response
through
competitive
endogenous
RNA
(ceRNA)
network
sponges.
This
review
highlights
research
progress
host-
virus-encoded
host-virus
interactions,
well
potential
diagnostic
biomarkers
therapeutic
targets
clinical
applications.
Language: Английский
Functional characterization of a novel protein-coding circular RNA, circRNA_1193, from the mAAP gene in silkworm and its role in antiviral defense against BmCPV
Li Song,
No information about this author
Zeen Shen,
No information about this author
Hongchuan Zhao
No information about this author
et al.
mBio,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
ABSTRACT
A
novel
circular
RNA,
circRNA_1193,
which
originates
from
the
membrane
alanyl
aminopeptidase-like
gene
in
silkworms,
was
explored
for
its
potential
function
and
regulatory
mechanism.
We
validated
presence
of
circRNA_1193
Bombyx
mori
cytoplasmic
polyhedrosis
virus
(BmCPV)-infected
silkworm
ovary
cell
line
(BmN)
cells
through
a
combination
reverse
transcription
polymerase
chain
reaction,
Northern
blotting,
situ
hybridization.
CircRNA_1193
exhibited
tissue-specific
expression,
being
highly
enriched
midgut
Malpighian
tubules,
displayed
specific
response
to
BmCPV
infection,
but
not
nucleopolyhedrovirus
or
lipopolysaccharide.
Functional
analyses
revealed
that
overexpression
suppressed
replication,
whereas
knockdown
increased
viral
replication.
Bioinformatic
internal
ribosome
entry
sites,
m6A
methylation
open
reading
frames
(ORFs)
within
suggesting
coding
capacity.
confirmed
translation
ORF
by
constructing
DsRed
reporter
vector
demonstrating
expression
transfected
cells.
Furthermore,
mutation
start
codon
abolished
antiviral
activity,
highlighting
crucial
role
translated
protein,
is
35
kDa
designated
as
VSP35.
our
data
suggest
formation
relies
on
complementary
flanking
sequences.
These
findings
unveil
protein-coding
RNA
silkworms
plays
critical
defense.
IMPORTANCE
This
study
identified
,
defense
against
(BmCPV).
demonstrated
exhibits
upregulated
possesses
activity.
Importantly,
we
show
encodes
protein
VSP35,
essential
function.
provide
new
insights
into
complex
mechanisms
RNAs
immunity
underscore
therapeutic
targets
diseases.
The
identification
with
activity
B.
has
broader
implications
understanding
evolution
diversity
host
viruses.
Language: Английский
Human and pathogen-encoded circular RNAs in viral infections: insights into functions and therapeutic opportunities
Nikolaus Mueller,
No information about this author
Adela Dujsikova,
No information about this author
Amrita Singh
No information about this author
et al.
Human Molecular Genetics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 30, 2025
Abstract
Circular
RNAs
(circRNAs)
are
emerging
as
important
regulatory
molecules
in
both
host
and
viral
systems,
acting
microRNA
sponges,
protein
decoys
or
scaffolds,
templates
for
translation.
Host-derived
circRNAs
increasingly
recognized
their
roles
immune
responses,
while
virus-encoded
circRNAs,
especially
those
from
DNA
viruses,
have
been
shown
to
modulate
cellular
machinery
favor
replication
evasion.
Recently,
RNA
were
also
discovered,
but
evidence
suggests
that
they
might
be
generated
using
a
different
mechanism
compared
the
produced
viruses.
This
review
highlights
recent
advances
our
understanding
of
virus-derived
with
focus
on
biological
contributions
pathogenesis.
Furthermore,
we
discuss
potential
biomarkers
application
therapeutic
targets
scaffolds
RNA-based
therapies.
Understanding
host-virus
interactions
offers
novel
insights
into
biology
opens
new
avenues
strategies
against
diseases
associated
cancers.
Language: Английский
CircMYO9A inhibits influenza A virus replication by dampening hemagglutinin cleavage via increasing SERPINE1/PAI-1 expression
Emerging Microbes & Infections,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 2, 2025
Circular
RNAs
(circRNAs)
represent
a
class
of
widespread
and
diverse
covalently
closed
circular
endogenous
that
play
critical
roles
in
regulating
gene
expression
mammals.
However,
the
regulatory
mechanisms
circRNAs
during
influenza
A
virus
(IAV)
infection
remain
largely
unexplored.
In
this
study,
we
screened
circRNA
transcription
profiles
WSN-infected
cells
to
identify
involved
viral
replication
identified
novel
differentially
expressed
RNA,
circMYO9A.
Mechanistically,
circMYO9A
acts
as
competing
RNA
(ceRNA)
for
SERPINE1/PAI-1
by
sponging
miR-6059-3p,
thereby
increasing
expression,
which
restricts
IAV
hemagglutinin
cleavage
subsequently
reduces
infectivity
progeny
viruses.
Importantly,
our
findings
demonstrate
significantly
inhibits
lungs
infected
mice,
potentially
their
survival
infection.
These
results
crucial
inhibiting
provide
insights
into
potential
therapeutic
strategies
involving
circRNAs.
Language: Английский
Regulation and Function of the Atypical IκBs—Bcl‐3, IκBNS, and IκBζ—in Lymphocytes and Autoimmunity
European Journal of Immunology,
Journal Year:
2025,
Volume and Issue:
55(5)
Published: May 1, 2025
ABSTRACT
Signaling
pathways
involving
NF‐κB
transcription
factors
have
essential
roles
in
inflammation,
immunity,
cell
proliferation,
differentiation,
and
survival.
Classical
IκB
proteins,
such
as
IκBα
IκBβ,
bind
to
via
ankyrin
repeats
sequester
the
cytoplasm
thus
suppress
activity.
Unlike
these
constitutively
expressed
classical
IκBs,
expression
of
atypical
IκBs
Bcl‐3,
NS
,
IκBζ
is
induced
immune
cells
after
recognition
antigens,
pathogen‐associated
molecular
patterns
(PAMPs)
or
cytokines,
upon
which
they
localize
nucleus
form
complexes
with
regulators
on
DNA.
Atypical,
nuclear
been
proposed
modulate
activity
a
context‐dependent
manner
can
either
inhibit
increase
gene
subset
target
genes.
This
complexity
may
be
related
function
different
factor
bridge
cofactors
epigenetic
modifiers.
Recent
research
has
identified
novel
genes
that
include
chemokines,
master
lymphocyte
underscoring
prominent
adaptive
autoimmune
responses.
Here,
we
summarize
our
current
understanding
lymphocytes
focus
their
emerging
role
autoimmunity.
Language: Английский
METTL3-mediated m6A modification of circCSDE1 promote Coxsackievirus replication by regulating the miR-891b/BAG3 axis
International Immunopharmacology,
Journal Year:
2025,
Volume and Issue:
159, P. 114905 - 114905
Published: May 22, 2025
Language: Английский
Circular RNAs in Viral Infection and Antiviral Treatment
Xin Yin,
No information about this author
Hongjun Li,
No information about this author
Yan Zhou
No information about this author
et al.
Cells,
Journal Year:
2024,
Volume and Issue:
13(23), P. 2033 - 2033
Published: Dec. 9, 2024
Circular
RNAs
(circRNAs)
are
a
class
of
noncoding
that
lack
the
5′-cap
structure
and
3′
poly(A)
tail.
Their
distinguishing
feature
is
5′
ends
covalently
linked
to
form
closed
circular
structure.
CircRNAs
have
longer
half-life
stronger
ribonuclease
resistance
compared
with
linear
RNA.
Viral
infections
lead
production
circRNA
molecules
through
transcription
splicing
mechanisms
host
cells.
circRNAs
produced
from
viral
genome
or
reactions
cell
gene.
They
participate
in
regulating
replication
many
viruses,
including
coronaviruses,
human
herpesviruses,
immunodeficiency
virus,
cytomegalovirus.
regulate
infection
process
by
modulating
expression
cells
affect
cellular
biological
processes.
Some
been
proposed
as
diagnostic
markers
for
infections.
In
this
review,
we
discussed
properties
virus-derived
circRNAs,
functions
diverse
viruses-derived
during
infections,
critical
role
host’s
antiviral
immune
defense.
Extensive
research
on
applications
can
help
us
better
understand
gene
regulatory
networks
disease
mechanisms.
Language: Английский