Zika virus infection induces expression of NRF2 and antioxidant systems in trophoblast cells DOI Creative Commons

Manuel Adrián Velázquez Cervantes,

Julio Angel Vázquez Martinez,

Luis Didider Gonzalez García

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: March 14, 2023

Abstract The nuclear factor erythroid 2-related 2 (NRF2) is a transcription that plays critical role in the xenobiotic and stress responses. During viral infection, NRF2 can modulate host metabolism innate immunity; however, most common activity of diseases controlling reactive oxygen species (ROS). Zika virus (ZIKV) involved vertical infection pregnancy, with reported fetal health consequences. However, possibility ZIKV regulates expression placental trophoblasts has not been investigated. In this report, we evaluated upregulation antioxidant enzymes trophoblast-like cell. These findings could help us understand mechanism underlying placenta during pregnancy.

Language: Английский

A state-of-the-art review on the NRF2 in Hepatitis virus-associated liver cancer DOI Creative Commons
Leila Kalantari, Zahra Rostami Ghotbabadi,

Arsalan Gholipour

et al.

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 9, 2023

Abstract According to a paper released and submitted WHO by IARC scientists, there would be 905,700 new cases of liver cancer diagnosed globally in 2020, with 830,200 deaths expected as direct result. Hepatitis B virus (HBV) hepatitis C (HCV), D (HDV) all play critical roles the pathogenesis hepatocellular carcinoma (HCC), despite rising prevalence HCC due non-infectious causes. Liver cirrhosis are devastating consequences HBV HCV infections, which widespread worldwide. Associated high mortality rate, these infections cause about 1.3 million annually primary globally. In addition causing insertional mutations viral gene integration, epigenetic alterations inducing chronic immunological dysfunction methods viruses turn hepatocytes into cancerous ones. While expanding our knowledge illness, identifying pathways also give possibilities for novel diagnostic treatment methods. Nuclear factor erythroid 2-related 2 (NRF2) activation is gaining popularity option oxidative stress (OS), inflammation, metabolic abnormalities. Numerous studies have shown that elevated Nrf2 expression linked HCC, providing more evidence HCC. This aberrant signaling drives cell proliferation, initiates angiogenesis invasion, imparts drug resistance. As result, this master regulator may promising target addition, common effect contributes pathogenesis, development, chronicity infection. However, certain suppress activity, helpful maintaining cellular homeostasis. paper, we discussed influence deregulation on life cycle associated HCV. We summed up mechanisms modulation deregulated viruses. Moreover, describe molecular mechanism modulated cancer, stem cells (LCSCs), caused

Language: Английский

Citations

18
NRF2-mediated regulation of lipid pathways in viral infection DOI
Khursheed Muzammil,

Zahraa Sabah Ghnim,

Ibrahim Saeed Gataa

et al.

Molecular Aspects of Medicine, Journal Year: 2024, Volume and Issue: 97, P. 101279 - 101279

Published: May 20, 2024

Language: Английский

Citations

7
Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways DOI Creative Commons
Solène Denolly, Alexey Stukalov, Uladzimir Barayeu

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Dec. 5, 2023

Abstract Zika virus (ZIKV) has emerged as a global health issue, yet neither antiviral therapy nor vaccine are available. ZIKV is an enveloped RNA virus, replicating in the cytoplasm close association with ER membranes. Here, we isolate membranes from ZIKV-infected cells and determine their proteome. Forty-six host cell factors enriched remodeled membranes, several of these having role redox methylation pathways. Four proteins characterized detail: thioredoxin reductase 1 (TXNRD1) contributing to folding disulfide bond containing modulating secretion; aldo-keto family member C3 (AKR1C3), regulating capsid protein abundance thus, assembly; biliverdin B (BLVRB) involved induced lipid peroxidation increasing stability viral transmembrane proteins; adenosylhomocysteinase (AHCY) indirectly promoting m 6 A by decreasing level S- adenosyl homocysteine immune evasion. These results highlight involvement enzymes life cycle accumulation at virally

Language: Английский

Citations

13
Metabolic response to CNS infection with flaviviruses DOI Creative Commons

Marta Dobrzyńska,

Anna Moniuszko‐Malinowska, Elżbieta Skrzydlewska

et al.

Journal of Neuroinflammation, Journal Year: 2023, Volume and Issue: 20(1)

Published: Sept. 29, 2023

Abstract Flaviviruses are arthropod-borne RNA viruses found worldwide that, when introduced into the human body, cause diseases, including neuroinfections, that can lead to serious metabolic consequences and even death. Some of diseases caused by flaviviruses occur continuously in certain regions, while others intermittently or sporadically, causing epidemics. most common West Nile virus, dengue tick-borne encephalitis Zika virus Japanese virus. Since all above-mentioned capable penetrating blood–brain barrier through different mechanisms, their actions also affect central nervous system (CNS). Like other viruses, flaviviruses, after entering contribute redox imbalance and, consequently, oxidative stress, which promotes inflammation skin cells, blood CNS. This review focuses on discussing effects stress resulting from pathogen invasion antiviral response host, ability evade changes exploit them for increased replication further progression infection, affects development sequelae difficulties therapy.

Language: Английский

Citations

10
Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub DOI Creative Commons

Guanning Su,

Jiao Liu,

Chenrui Duan

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 71, P. 103112 - 103112

Published: March 4, 2024

The Warburg effect, also referred as aerobic glycolysis, is a common metabolic program during viral infection. Through targeted metabolomics combined with biochemical experiments and various cell models, we investigated the central carbon metabolism (CCM) profiles of cells infected porcine deltacoronavirus (PDCoV), an emerging enteropathogenic coronavirus zoonotic potential. We found that PDCoV infection required glycolysis but decreased glycolytic flux, exhibiting non-Warburg effect characterized by pyruvic acid accumulation. Mechanistically, enhanced pyruvate kinase activity to promote anabolism, process generates concomitant ATP production. hijacked catabolism increase biosynthesis non-essential amino acids (NEAAs), suggesting essential hub for scavenge host energy metabolites. Furthermore, facilitated glutaminolysis synthesis NEAA pyrimidines optimal proliferation. Our work supports novel CCM model after provides potential anti-PDCoV drug targets.

Language: Английский

Citations

3
Effects of oxidative stress on viral infections: an overview DOI Creative Commons
Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama‐Kohara

et al.

npj Viruses, Journal Year: 2025, Volume and Issue: 3(1)

Published: April 12, 2025

Viral infections can trigger increased reactive oxygen species (ROS) production and a reduced antioxidant response in the host, leading to redox stress, inflammation, apoptosis, ultimately, cell tissue damage, which contribute disease development. A better understanding of how ROS contributes viral pathogenesis is critical for development novel therapeutic interventions. In this review, we discuss current knowledge on its effects across various infections, including severe acute respiratory syndrome-coronavirus-2, influenza virus, dengue Zika hepatitis B C human immunodeficiency virus improve future preventive strategies these infections.

Language: Английский

Citations

0
Nrf2 exerted potential antioxidant and anti-inflammatory activities to inhibit SGIV replication in vitro DOI

Lin Liu,

Dong-Miao Xiao,

Mengdi Yuan

et al.

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742686 - 742686

Published: May 1, 2025

Language: Английский

Citations

0
African swine fever virus enhances viral replication by increasing intracellular reduced glutathione levels, which suppresses stress granule formation DOI Creative Commons
Han Gao,

Tian-Yuan Gu,

Xiaopeng Gao

et al.

Veterinary Research, Journal Year: 2024, Volume and Issue: 55(1)

Published: Dec. 20, 2024

Abstract African swine fever virus (ASFV) is a DNA that has significantly impacted the global industry. Currently, there are no effective therapies or vaccines against ASFV. Stress granules (SGs), known for their antiviral properties, not induced during ASFV infection, even though reactive oxygen species (ROS) generated. The mechanism by which regulates SGs formation remains unclear. This study demonstrates antagonises and increases intracellular levels of reduced glutathione (GSH) levels. use GSH inhibitor BSO activator NAC confirmed ASFV-induced increase in helps to suppress influences viral replication. Additionally, this revealed enhances upregulating antioxidant transcription factor NRF2, as well factors involved synthesis regeneration, such GCLC, those related ferroptosis pathway, SLC7A11. Furthermore, uncovered manipulates activating mitochondrial protein AIFM1. regulatory inhibit SGs, thereby creating an optimal environment These findings provide new insights into molecular strategies employed

Language: Английский

Citations

2
Zika virus infection induces expression of NRF2 and antioxidant systems in trophoblast cells DOI

Manuel Adrián Velázquez Cervantes,

Julio Angel Vázquez Martinez,

Luis Didider Gonzalez García

et al.

Virus Genes, Journal Year: 2023, Volume and Issue: 59(5), P. 781 - 785

Published: June 16, 2023

Language: Английский

Citations

5
The Influence of Metabolism on Immune Response: A Journey to Understand Immunometabolism in the Context of Viral Infection DOI Creative Commons

Daed El Safadi,

Aurélie Paulo-Ramos,

Mathilde Hoareau

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(12), P. 2399 - 2399

Published: Dec. 9, 2023

In recent years, the emergence of concept immunometabolism has shed light on pivotal role that cellular metabolism plays in both activation immune cells and development programs. The antiviral response, a widely distributed defense mechanism used by infected cells, serves to not only control infections but also attenuate their deleterious effects. exploration orchestrating response represents burgeoning area research, especially considering escalating incidence viral outbreaks coupled with increasing prevalence metabolic diseases. Here, we present review current knowledge regarding during infections. Initially, delve into examining its application field cancer-a domain long spearheaded inquiries this fascinating intersection disciplines. Subsequently, explore examples whose is intricately regulated processes. Progressing systematic approach, our aim unravel potential defense, placing significant emphasis innate canonical interferon response.

Language: Английский

Citations

5