Zika virus infection induces expression of NRF2 and antioxidant systems in trophoblast cells DOI Creative Commons

Manuel Adrián Velázquez Cervantes,

Julio Angel Vázquez Martinez,

Luis Didider Gonzalez García

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: March 14, 2023

Abstract The nuclear factor erythroid 2-related 2 (NRF2) is a transcription that plays critical role in the xenobiotic and stress responses. During viral infection, NRF2 can modulate host metabolism innate immunity; however, most common activity of diseases controlling reactive oxygen species (ROS). Zika virus (ZIKV) involved vertical infection pregnancy, with reported fetal health consequences. However, possibility ZIKV regulates expression placental trophoblasts has not been investigated. In this report, we evaluated upregulation antioxidant enzymes trophoblast-like cell. These findings could help us understand mechanism underlying placenta during pregnancy.

Language: Английский

Zika virus infection induces expression of NRF2 and antioxidant systems in trophoblast cells DOI

Manuel Adrián Velázquez Cervantes,

Julio Angel Vázquez Martinez,

Luis Didider Gonzalez García

et al.

Virus Genes, Journal Year: 2023, Volume and Issue: 59(5), P. 781 - 785

Published: June 16, 2023

Language: Английский

Citations

5
The Influence of Metabolism on Immune Response: A Journey to Understand Immunometabolism in the Context of Viral Infection DOI Creative Commons

Daed El Safadi,

Aurélie Paulo-Ramos,

Mathilde Hoareau

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(12), P. 2399 - 2399

Published: Dec. 9, 2023

In recent years, the emergence of concept immunometabolism has shed light on pivotal role that cellular metabolism plays in both activation immune cells and development programs. The antiviral response, a widely distributed defense mechanism used by infected cells, serves to not only control infections but also attenuate their deleterious effects. exploration orchestrating response represents burgeoning area research, especially considering escalating incidence viral outbreaks coupled with increasing prevalence metabolic diseases. Here, we present review current knowledge regarding during infections. Initially, delve into examining its application field cancer-a domain long spearheaded inquiries this fascinating intersection disciplines. Subsequently, explore examples whose is intricately regulated processes. Progressing systematic approach, our aim unravel potential defense, placing significant emphasis innate canonical interferon response.

Language: Английский

Citations

5
Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids DOI Creative Commons

Anja Schöbel,

Vinícius Pinho dos Reis,

Rabea Burkhard

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Sept. 5, 2024

Language: Английский

Citations

1
Zika virus restriction of host antioxidant response is mediated by intracellular NS1 and reveals its ability to upregulate Bach1 expression DOI Creative Commons
Grégorie Lebeau,

Daed El Safadi,

Mathilde Hoarau

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2023, Volume and Issue: 690, P. 149312 - 149312

Published: Nov. 23, 2023

Language: Английский

Citations

1
Dysregulated nicotinamide adenine dinucleotide metabolome in patients hospitalized with COVID‐19 DOI Creative Commons
Rodrigo J. Valderrábano, Benjamin Wipper, Karol M. Pencina

et al.

Aging Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Abstract Nicotinamide adenine dinucleotide (NAD + ) depletion has been postulated as a contributor to the severity of COVID‐19; however, no study prospectively characterized NAD and its metabolites in relation disease patients with COVID‐19. We measured 56 hospitalized COVID‐19 two control groups without COVID‐19: (1) 31 age‐ sex‐matched adults comorbidities, (2) 30 comorbidities. Blood concentrations group were only slightly lower than ( p < 0.05); plasma 1‐methylnicotinamide significantly higher (439.7 ng/mL, 95% CI: 234.0, 645.4 ng/mL) controls (44.5 15.6, 73.4) healthy (18.1 CI 15.4, 20.8; 0.001 for each comparison). Plasma nicotinamide also comorbidities group. 2‐methyl‐2‐pyridone‐5‐carboxamide (2‐PY), but not , associated increased risk death (HR = 3.65; 1.09, 12.2; 0.036) escalation level care 2.90, 1.01, 8.38, 0.049). RNAseq RTqPCR analyses PBMC mRNA found upregulation multiple genes involved synthesis well degradation, dysregulation ‐dependent processes including immune response, DNA repair, metabolism, apoptosis/autophagy, redox reactions, mitochondrial function. are modestly reduced turnover is substantially both biosynthesis supporting rationale NAD+ augmentation attenuate severity.

Language: Английский

Citations

0
Zika virus infection induces expression of NRF2 and antioxidant systems in trophoblast cells DOI Creative Commons

Manuel Adrián Velázquez Cervantes,

Julio Angel Vázquez Martinez,

Luis Didider Gonzalez García

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: March 14, 2023

Abstract The nuclear factor erythroid 2-related 2 (NRF2) is a transcription that plays critical role in the xenobiotic and stress responses. During viral infection, NRF2 can modulate host metabolism innate immunity; however, most common activity of diseases controlling reactive oxygen species (ROS). Zika virus (ZIKV) involved vertical infection pregnancy, with reported fetal health consequences. However, possibility ZIKV regulates expression placental trophoblasts has not been investigated. In this report, we evaluated upregulation antioxidant enzymes trophoblast-like cell. These findings could help us understand mechanism underlying placenta during pregnancy.

Language: Английский

Citations

0