Cancer and Metastasis Reviews, Journal Year: 2024, Volume and Issue: 43(4), P. 1257 - 1277
Published: July 22, 2024
Language: Английский
Archives of Dermatological Research, Journal Year: 2024, Volume and Issue: 316(6)
Published: May 25, 2024
Abstract Psoriasis vulgaris (PV) and Atopic dermatitis (AD) are the two major types of immune-mediated inflammatory skin disease (IMISD). Limited studies reported association between Ubiquitin-conjugating enzyme E2 (UBE2) IMISD. We employed a two-sample Mendelian randomization (MR) study to assess causality UBE2 PV & AD. genome-wide (GWAS) data were collected. The inverse variance weighted (IVW) method was utilized as principal in our study, with additional using MR-Egger, median, simple mode, mode methods. MR-Egger intercept test, Cochran’s Q MR-Pleiotropy RESidual Sum Outlier (MR-PRESSO) leave-one-out analysis conducted identify heterogeneity pleiotropy, colocalization also performed. results showed that variant 1 (UBE2V1) causally associated (OR = 0.909, 95% CI: 0.830–0.996, P 0.040), L3 (UBE2L3) AD 0.799, 0.709–0.990, < 0.001). Both UBE2V1 UBE2L3 may play protective roles patients or AD, respectively. No other significant result has been investigated. pleiotropy observed. This provided new evidence relationship PV, Our MR suggested plays an inhibitory role progression, These could be novel effective ways treat
Language: Английский
Citations
4
Oncogene, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
Abstract Persistent infection with high-risk (HR) human papillomaviruses (HPVs) is responsible for approximately 5% of cancer cases worldwide, including a growing number oropharyngeal and anogenital cancers. The major HPV oncoproteins, E6 E7, act together to manipulate cellular pathways involved in the regulation proliferation, cell cycle survival, ultimately driving malignant transformation. Protein ubiquitination ubiquitin proteasome system (UPS) often deregulated upon viral oncogenesis. E7 interact disrupt multiple components machinery promote persistence, which can also result transformation formation tumours. This review highlights ways manipulates protein ubiquitin-like how this contributes tumour development. Furthermore, we discuss understanding interactions between could lead novel therapeutic targets that are urgent need HPV+ carcinomas.
Language: Английский
Citations
0
Journal of Virology, Journal Year: 2025, Volume and Issue: unknown
Published: March 25, 2025
ABSTRACT High-risk human papillomaviruses (HR HPV)-16 and -18, other closely related subtypes, are associated with at least 90% of cervical cancers. Cervical cancers derived cell lines continuously express high levels the HPV oncoprotein E7, known to degrade tumor suppressor retinoblastoma protein (pRB). This E7–pRB interaction is important for maintenance progression malignancy. In case E6, substrate recognition has been reported play an role in stabilizing viral oncoprotein; however, such regulation E7 so far not investigated. Using biochemical, immunostaining, clonogenic assays, we describe intriguing pRB stabilization HPV-positive cervical-cancer-derived lines. The knockdown expression by RNA interference results a significant decrease CaSki, SiHa, HeLa, C-4 I cells. We show that regulates transcription levels, significantly reduces half-life twofold SiHa HeLa also demonstrate destabilization caused inhibition proliferation colony formation HPV-16 -18 E7-positive Furthermore, wild-type pRB-depleted cells restored levels. Therefore, propose pRB, addition being degradation target crucial its stabilization. IMPORTANCE papillomavirus (HPV) proteins E6 cooperatively contribute tumorigenesis disrupting cellular targets. These oncoproteins degraded via proteasome pathway; they expressed cancer protein, high-risk (HR) oncoprotein. Several studies have shown binding E7-mediated inactivation demonstrated how respond presence absence E7. However, modulatory on reported. Here, report novel regulatory relationship between pRB. found continuous critical this pRB-related occurs part through enhanced turnover. Thus, our findings provide new insights into importance driving tumorigenesis.
Language: Английский
Citations
0
Veterinary Microbiology, Journal Year: 2024, Volume and Issue: 298, P. 110271 - 110271
Published: Sept. 30, 2024
Language: Английский
Citations
2
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 6, 2024
The loss of major histocompatibility complex class I (MHC-I) molecules has been proposed as a mechanism by which cancer cells evade tumor-specific T in immune checkpoint inhibitor (ICI)-refractory patients. Nevertheless, the downregulate MHC-I is poorly understood. We report here that membrane-associated RING-CH-type finger 8 (MARCHF8), upregulated human papillomavirus (HPV), ubiquitinates and degrades proteins HPV-positive head neck (HPV+ HNC). MARCHF8 knockdown restores levels on HPV+ HNC cells. further reveal
Language: Английский
Citations
1
Cells, Journal Year: 2024, Volume and Issue: 13(8), P. 698 - 698
Published: April 17, 2024
The cellular transmembrane protein MARCH8 impedes the incorporation of various viral envelope glycoproteins, such as HIV-1 glycoprotein (Env) and vesicular stomatitis virus G-glycoprotein (VSV-G), into virions by downregulating them from surface virus-producing cells. This downregulation significantly reduces efficiency infection. In this study, we aimed to further characterize host investigating its species specificity domains responsible for antiviral activity, well ability inhibit cell-to-cell We found that function is conserved in rhesus macaque, mouse, bovine versions. RING-CH these versions are functionally important inhibiting Env VSV-G-pseudovirus infection, whereas tyrosine motifs crucial former only, consistent with findings human MARCH8. Through analysis chimeric proteins between non-antiviral MARCH3, determined both N-terminal C-terminal cytoplasmic tails, presumably domain, critical activity. Notably, unable block likely due insufficient Env. These offer insights understanding biology protein.
Language: Английский
Citations
0
Cancer and Metastasis Reviews, Journal Year: 2024, Volume and Issue: 43(4), P. 1257 - 1277
Published: July 22, 2024
Language: Английский
Citations
0