Cited by The underlying mechanism of Porcine Teschovirus 2 3Cpro antagonizing the NLRP3 inflammasome

Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium DOI

Kaixin Liang, Katherine C. Barnett, Martin Hsu

et al.

Science Immunology, Journal Year: 2024, Volume and Issue: 9(97)

Published: July 12, 2024

Virus-induced cell death is a key contributor to COVID-19 pathology. Cell induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) well studied in myeloid cells but less its primary host type, angiotensin-converting enzyme (ACE2)–expressing human airway epithelia (HAE). SARS-CoV-2 induces apoptosis, necroptosis, and pyroptosis HAE organotypic cultures. Single-cell limiting-dilution analysis revealed that necroptosis the event infected cells, whereas uninfected bystanders undergo occurs later during infection. Mechanistically, viral Z-RNA binding Z-DNA–binding protein 1 (ZBP1) lung tissues from patients with COVID-19. The Delta (B.1.617.2) variant, which causes more disease than Omicron (B1.1.529) humans, associated orders of magnitude–greater Z-RNA/ZBP1 interactions, severity animal models. Thus, robust ZBP1-mediated severity.

Language: Английский

Citations

Exploring enterovirus pathogenesis and cancer therapy potential through reverse genetics DOI