Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 16, 2025
Language: Английский
Journal of Allergy and Clinical Immunology, Journal Year: 2023, Volume and Issue: 152(5), P. 1179 - 1195
Published: June 13, 2023
Atopic dermatitis (AD) is an inflammatory disorder characterized by dominant type 2 inflammation leading to chronic pruritic skin lesions, allergic comorbidities, and Staphylococcus aureus colonization infections. S thought play a role in AD severity.
Language: Английский
Citations
42
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 4025 - 4025
Published: Feb. 16, 2023
Staphylococcus aureus is an important pathogen that causes a high number of infections and one the leading death in hospitalized patients. Widespread antibiotic resistance such as methicillin-resistant S. (MRSA) has prompted research into potential anti-virulence-targeted approaches. Targeting accessory gene regulator (Agr) quorum-sensing system, master virulence, most frequently proposed anti-virulence strategy for aureus. While much effort been put discovery screening Agr inhibitory compounds, vivo analysis their efficacy animal infection models still rare reveals various shortcomings problems. These include (i) almost exclusive focus on topical skin models, (ii) technical problems leave doubt to whether observed effects are due quorum-quenching, (iii) counterproductive biofilm-increasing effects. Furthermore, potentially because latter, invasive associated with dysfunctionality. Altogether, drugs nowadays seen low enthusiasm given failure provide sufficient evidence after more than two decades since initiation efforts. However, current inhibition-based probiotic approaches may lead new application inhibition strategies preventing by targeting colonization or otherwise difficult-to-treat atopic dermatitis.
Language: Английский
Citations
30
Microbiology, Journal Year: 2023, Volume and Issue: 169(8)
Published: Aug. 3, 2023
In Gram-positive bacteria such as Staphylococcus aureus and the coagulase-negative staphylococci (CoNS), accessory gene regulator ( agr ) is a highly conserved but polymorphic quorum-sensing system involved in colonization, virulence biofilm development. Signalling via depends on interaction of an autoinducing peptide (AIP) with AgrC, transmembrane sensor kinase that, once phosphorylated activates response AgrA. This turn autoinduces AIP biosynthesis drives target expression directly AgrA or post-transcriptional regulator, RNAIII. this review we describe molecular mechanisms underlying -mediated generation of, to, AIPs basis AIP-dependent activation inhibition AgrC. How environment impacts functionality considered consequences dysfunction for infection explored. We also discuss concept AIP-driven competitive interference between S. CoNS its anti-infective potential.
Language: Английский
Citations
25
JAMA Oncology, Journal Year: 2024, Volume and Issue: 10(4), P. 516 - 516
Published: Feb. 1, 2024
The interindividual differences in severity of acute radiation dermatitis are not well understood. To date, the pathomechanism and interplay microbiome radiodermatitis before during treatment remain largely unknown.
Language: Английский
Citations
12
Allergy, Journal Year: 2024, Volume and Issue: 79(6), P. 1470 - 1484
Published: Feb. 3, 2024
The skin microbiome is an extensive community of bacteria, fungi, mites, viruses and archaea colonizing the skin. Fluctuations in composition have been observed atopic dermatitis (AD) food allergy (FA), particularly early life, established disease, associated with therapeutics. However, AD a multifactorial disease characterized by barrier aberrations modulated genetics, immunology, environmental influences, thus not sole feature this disease. Future research should focus on mechanistic understanding how early-life microbial shifts may influence FA onset, to guide potential intervention strategies or as biomarkers identify high-risk infants who benefit from possible microbiome-based biotherapeutic strategies. Harnessing microbes biotherapeutics emerging field, but more work needed investigate whether approach can lead sustained clinical responses.
Language: Английский
Citations
12
Antibiotics, Journal Year: 2024, Volume and Issue: 13(1), P. 49 - 49
Published: Jan. 4, 2024
The skin is the largest human organ and responsible for many important functions, such as temperature regulation, water transport, protection from external insults. It colonized by several microorganisms that interact with each other host, shaping microbial structure community dynamics. Through these interactions, microbiota can inhibit pathogens through mechanisms production of bacteriocins, proteases, phenol soluble modulins (PSMs), fermentation. Furthermore, commensals produce molecules antivirulence activity, reducing potential to adhere invade tissues. Microorganisms are also able sense environment shape their behavior in response signals modulation gene expression. Additionally, microbiota-derived compounds affect pathogen expression, including expression virulence determinants. Although most studies related interactions have been directed towards elucidating competition mechanisms, use products species benefit. In this review, we will discuss which biotechnological applications originating already reported literature.
Language: Английский
Citations
9
Microorganisms, Journal Year: 2023, Volume and Issue: 11(8), P. 1899 - 1899
Published: July 27, 2023
Bioprospecting is the discovery and exploration of biological diversity found within organisms, genetic elements or produced compounds with prospective commercial therapeutic applications. The human skin an ecological niche which harbours a rich compositional microbiome stemming from multifactorial interactions between host microbiota facilitated by exploitable effector compounds. Advances in understanding microbial colonisation mechanisms alongside species strain have revealed novel chemical displays applicative potential. Studies elucidating organismal interfaces concomitant central processes biology begun to unravel potential wealth molecules can exploited for their proposed functions. A variety skin-microbiome-derived display applications, ranging antioncogenic agents relevant cancer therapy treatment strategies antimicrobial-resistant bacterial fungal infections. Considerable opportunities emerged translation personal care products, such as topical mitigate various conditions acne eczema. Adjacent compound developments focused on cosmetic applications reducing ageing its associated changes properties microbiome. contains applications; however, considerable work required vitro findings vivo models ensure translatability.
Language: Английский
Citations
22
Nature Immunology, Journal Year: 2023, Volume and Issue: 24(6), P. 895 - 898
Published: April 20, 2023
Language: Английский
Citations
19
Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13
Published: April 14, 2023
The skin is home to various bacteria, archaea, fungi, and viruses, collectively referred as the microbiota. Patients with certain diseases reportedly have unique “dysbiosis,” a condition involving imbalanced microbiota, suggesting that dysbiosis in may be either causal or consequence of specific diseases. Atopic dermatitis (AD) most common allergic disease affects 15-20% children 2-10% adults worldwide. Both intrinsic genetic factors, such susceptibility type 2 inflammation barrier dysfunction, extrinsic environmental air pollen contribute AD. Staphylococcus aureus , which does not often colonize healthy individuals, commonly identified lesional patients AD correlated flare. However, role S. pathogenesis has been elucidated. Here, we discuss pathological behavior focusing on accessory gene regulator (Agr) quorum sensing, fundamental bacterial cell-to-cell interaction mechanism other members microbial community. Importantly, beyond bacteria-bacteria interactions, Agr sensing system also regulates virulence induce IL-17-dependent host. Furthermore, colonization Agr-positive early life accelerates development pediatric Finally, aim highlight current efforts establish novel therapeutic methods ameliorate prevent through Agr-targeted intervention.
Language: Английский
Citations
17
Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 154(1), P. 31 - 41
Published: May 16, 2024
Language: Английский
Citations
7